Pharmacology: Antihypertensive Agents

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Questions and Answers

What is a potential adverse effect of using the described drug class during pregnancy?

  • Hypotension (correct)
  • Angioedema
  • Bradycardia
  • Cough

Which adverse effect is less common with the described drug class compared to ACE inhibitors?

  • Renal toxicity
  • Hyperkalemia
  • Hypokalemia
  • Cough (correct)

What is a similarity between the adverse effects of the described drug class and ACE inhibitors?

  • Bradycardia
  • Hypertension
  • Pulmonary toxicity
  • Risk of angioedema (correct)

What is the mechanism of action of diuretics in managing hypertension?

<p>Block the Na/Cl transporter in the distal convoluted tubule (C)</p> Signup and view all the answers

How do sympathoplegics contribute to managing hypertension?

<p>Reducing central sympathetic outflow (A)</p> Signup and view all the answers

Why are combinations of two or more antihypertensive drugs often used for treatment?

<p>Because the drugs act differently (B)</p> Signup and view all the answers

Which of the following statements about ACE Inhibitors is FALSE?

<p>They increase the synthesis of angiotensin II (A)</p> Signup and view all the answers

What is the main therapeutic use of ACE Inhibitors?

<p>Controlling hypertension (D)</p> Signup and view all the answers

Which of the following is a unique pharmacologic property of Angiotensin Receptor Blockers (ARBs) compared to ACE Inhibitors?

<p>They inhibit bradykinin metabolism (B)</p> Signup and view all the answers

Which drug class does Losartan belong to?

<p>Angiotensin Receptor Blockers (ARBs) (A)</p> Signup and view all the answers

Flashcards

Pregnancy and Hypotension risk

Can cause low blood pressure in the mother, potentially affecting the fetus.

Cough (vs. ACE inhibitors)

Less likely to cause this persistent throat-clearing side effect, unlike ACE inhibitors.

Angioedema Risk

Both drug classes carry a risk of causing swelling, especially around the face and throat.

Diuretics: Mechanism

Reduce blood pressure by preventing sodium and chloride reabsorption in the kidneys, leading to fluid loss.

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Sympathoplegics: Action

Lower blood pressure by decreasing the sympathetic nervous system's activity, which reduces heart rate and blood vessel constriction.

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Combination Therapy

Antihypertensive drugs can target blood pressure in different ways, so a combination of drugs is often used to achieve optimal blood pressure.

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ACE Inhibitors & Angiotensin II

ACE Inhibitors prevent the conversion of angiotensin I to angiotensin II, therefore will decrease the synthesis of angiotensin II.

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ACE Inhibitors Use

Primarily used to lower blood pressure, reducing the risk of cardiovascular events.

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ARBs vs ACE Inhibitors

ARBs block the Angiotensin II receptors, while ACE Inhibitors inhibit the enzyme that produces Angiotensin II and break down bradykinin.

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Losartan Drug Class

Angiotensin Receptor Blockers (ARBs) block the action of angiotensin II by preventing it from binding to its receptors in the blood vessels and other tissues.

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