Podcast
Questions and Answers
Which of the following anticancer drugs does not act as a kinase inhibitor?
Which of the following anticancer drugs does not act as a kinase inhibitor?
- Axitinib
- Trastuzumab (correct)
- Ceritinib
- Imatinib
What is considered the most effective drug combination for eradicating H. pylori infestation when there are no antibiotic contraindications?
What is considered the most effective drug combination for eradicating H. pylori infestation when there are no antibiotic contraindications?
- Esomeprazole + Clarithromycin + Metronidazole
- Esomeprazole + Cimetidine + Clarithromycin
- Clarithromycin + Esomeprazole
- Esomeprazole + Clarithromycin + Amoxicillin (correct)
Which of the following NSAIDs is recognized as the most selective COX-2 inhibitor?
Which of the following NSAIDs is recognized as the most selective COX-2 inhibitor?
- Diclofenac
- Celecoxib (correct)
- Ibuprofen
- Indomethacin
The HAART regimen is primarily used to treat which infection?
The HAART regimen is primarily used to treat which infection?
What is the maximum recommended daily dose of paracetamol for adults?
What is the maximum recommended daily dose of paracetamol for adults?
Under which INR values is the Tranexamic acid mouthwash protocol recommended?
Under which INR values is the Tranexamic acid mouthwash protocol recommended?
Barbiturates and benzodiazepines increase the opening of the GABAA - Cl- channel by which mechanisms?
Barbiturates and benzodiazepines increase the opening of the GABAA - Cl- channel by which mechanisms?
How does Cefalexin act as an antibacterial drug?
How does Cefalexin act as an antibacterial drug?
Which antiarrhythmic drug exhibits mechanisms most similar to that of sotalol?
Which antiarrhythmic drug exhibits mechanisms most similar to that of sotalol?
Which anxiolytic medication is considered safe for patients with a history of drug dependence?
Which anxiolytic medication is considered safe for patients with a history of drug dependence?
Which drug is NOT a DNA polymerase inhibitor?
Which drug is NOT a DNA polymerase inhibitor?
Which penicillin is resistant to penicillinase?
Which penicillin is resistant to penicillinase?
Which of the following approaches does NOT help reduce the development of antibiotic resistance?
Which of the following approaches does NOT help reduce the development of antibiotic resistance?
Which of the following is NOT a third-generation cephalosporin?
Which of the following is NOT a third-generation cephalosporin?
Which drug is typically administered with folinic acid after high doses of methotrexate?
Which drug is typically administered with folinic acid after high doses of methotrexate?
Which of these is a triazole antifungal medication?
Which of these is a triazole antifungal medication?
Ibuprofen is classified as which type of NSAID?
Ibuprofen is classified as which type of NSAID?
Which antibiotic is contraindicated for use with neuromuscular junction blockers?
Which antibiotic is contraindicated for use with neuromuscular junction blockers?
Which dosage schedule is recommended for oral sedation in dentistry?
Which dosage schedule is recommended for oral sedation in dentistry?
Carbidopa is used with levodopa primarily because it:
Carbidopa is used with levodopa primarily because it:
Which of the following is classified as a Lincosamide?
Which of the following is classified as a Lincosamide?
Which antibacterial drug binds to the 50S ribosomal subunit but is not classified as a macrolide?
Which antibacterial drug binds to the 50S ribosomal subunit but is not classified as a macrolide?
Which chemotherapeutic agent is most likely to cause hemorrhagic cystitis due to hematoma formation in the urinary bladder?
Which chemotherapeutic agent is most likely to cause hemorrhagic cystitis due to hematoma formation in the urinary bladder?
Which of the following analgesics is considered a very weak anesthetic with a B coefficient of 0.5?
Which of the following analgesics is considered a very weak anesthetic with a B coefficient of 0.5?
Which property combination is characteristic of most NSAIDs?
Which property combination is characteristic of most NSAIDs?
Which cancer chemotherapeutic agents are classified as antimetabolites?
Which cancer chemotherapeutic agents are classified as antimetabolites?
Which combination of drugs would be effective in treating erythematous candidiasis?
Which combination of drugs would be effective in treating erythematous candidiasis?
Which antibacterial drug is known for inhibiting cell wall synthesis?
Which antibacterial drug is known for inhibiting cell wall synthesis?
Which option includes all agents known to act as antimetabolites in chemotherapy?
Which option includes all agents known to act as antimetabolites in chemotherapy?
Which drug, when taken in toxic doses, is most likely to cause respiratory alkalosis and systemic acidosis?
Which drug, when taken in toxic doses, is most likely to cause respiratory alkalosis and systemic acidosis?
Which cytoprotective drug can be effectively combined with high-dose NSAIDs to minimize the risk of peptic ulcer disease?
Which cytoprotective drug can be effectively combined with high-dose NSAIDs to minimize the risk of peptic ulcer disease?
Which topical corticosteroid is LEAST appropriate for treating severe lichen planus?
Which topical corticosteroid is LEAST appropriate for treating severe lichen planus?
Which condition is LEAST LIKELY to require antibiotic prophylaxis to prevent infective endocarditis?
Which condition is LEAST LIKELY to require antibiotic prophylaxis to prevent infective endocarditis?
What is the primary concern when sildenafil is administered with organic nitrates?
What is the primary concern when sildenafil is administered with organic nitrates?
Which of the following concerns should be prioritized in a patient undergoing extraction of a 3rd molar who is on cyclosporine A?
Which of the following concerns should be prioritized in a patient undergoing extraction of a 3rd molar who is on cyclosporine A?
What potential effect does long-term use of NSAIDs have on a patient with a history of PUD?
What potential effect does long-term use of NSAIDs have on a patient with a history of PUD?
In the context of managing arthritic pain and a history of PUD, which NSAID carries the highest risk?
In the context of managing arthritic pain and a history of PUD, which NSAID carries the highest risk?
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Study Notes
Antibiotics
- Erythromycin is a macrolide antibiotic
- Cefuroxime is not a 3rd generation cephalosporin
- Ceftazidime, Ceftriaxone, Ceftaroline, and Cefotaxime are all 3rd generation cephalosporins
- Clindamycin is a Lincosamide antibiotic
- Gentamicin should not be used with NMJ blockers like tubocurarine
- Doxycycline binds to the 30S ribosomal subunit and inhibits protein synthesis
- Amoxicillin, Doxycycline and Ciprofloxacin can be used with NMJ blockers
- Flucloxacillin is a penicillinase-resistant penicillin
- Benzylpenicillin, Piperacillin, Amoxicillin, and Phenoxymethylpenicillin are all penicillins susceptible to penicillinase
- Broad-spectrum drugs can reduce the development of resistance
Antifungal Drugs
- Ketoconazole is a triazole antifungal drug
- Itraconazole is a triazole antifungal drug
- Amphotericin B, Clotrimazole and Miconazole are not triazole antifungals
Other Drugs
- Folinic acid is frequently administered shortly after a high dose of methotrexate
- Ibuprofen is a propionic acid derivative
- Carbidopa potentiates the central effects of levodopa
- Mercaptoethansulfonate is usually given with cyclophosphamide to ameliorate hemorrhagic cystitis
- Sildenafil is contraindicated in patients taking organic nitrates
- Cyclosporine A and Warfarin are drugs of concern when considering a dental procedure
- Clindamycin binds to the 50S ribosomal subunit and inhibits protein synthesis
- Cyclophosphamide causes hematoma in the urinary bladder leading to hemorrhagic cystitis
- Nitrous oxide is a potent analgesic but a very weak anaesthetic
- Most NSAIDs are antipyretic, anti-inflammatory and analgesic
- Mercaptopurine, Fluorouracil, and Cytarabine are antimetabolites
- Nystatin and Miconazole are suitable treatments for erythematous candidiasis
- Vancomycin acts by inhibiting cell wall synthesis
- Trastuzumab is not a kinase inhibitor
- Ceritinib, Imatinib, and Axitinib are all kinase inhibitors
- Esomeprazole + Clarithromycin + Amoxicillin is the most effective combination for H. pylori eradication
- Celecoxib is the most selective COX-2 inhibitor
- The HAART regimen is used to treat Human Immunodeficiency Virus infection
- The maximum recommended dose of paracetamol in a day is 4000mg
- Misoprostol is a cytoprotective drug that can be used with NSAIDs to reduce the risk of peptic ulcer disease
- Hydrocortisone is the least potent topical corticosteroid therefore inappropriate for severe lichen planus
- Prosthetic heart valve, valvular heart disease, previous infective endocarditis, and cyanotic congenital heart defects are all indications for antibiotic prophylaxis to prevent infective endocarditis
- Aspirin causes respiratory alkalosis and systemic acidosis in toxic doses
- Beta-lactam antibiotics inhibit cell wall synthesis by inhibiting peptidoglycan cross-linking
- Sotalol is most similar in action to Amiodarone in the treatment of cardiac arrhythmias
- Buspirone is a safe anxiolytic for patients with a history of drug dependence
- Abacavir is not a DNA Polymerase inhibitor
- Aciclovir, Valaciclovir, Valganciclovir, and Ganciclovir are all DNA polymerase inhibitors
- Cefalexin inhibits cell wall synthesis by inhibiting peptidoglycan cross-linking
- Barbiturates increase the frequency of opening and benzodiazepines increase the duration of opening of the GABAA-Cl- channel
- Tranexamic acid mouthwash protocol should be recommended when INR value is 2.5, 2.8 or 3.5
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