Podcast
Questions and Answers
What is the primary purpose of integrin antagonists like natalizumab and vedolizumab?
What is the primary purpose of integrin antagonists like natalizumab and vedolizumab?
Which route of administration is used for integrin antagonists?
Which route of administration is used for integrin antagonists?
Which of the following indications is associated with interleukin-12/23 inhibitors like ustekinumab?
Which of the following indications is associated with interleukin-12/23 inhibitors like ustekinumab?
What significant precaution should be taken when administering ustekinumab?
What significant precaution should be taken when administering ustekinumab?
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What class of drugs does tofacitinib belong to, and what is its primary action?
What class of drugs does tofacitinib belong to, and what is its primary action?
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What is the primary mechanism of action for 5-ASA derivatives?
What is the primary mechanism of action for 5-ASA derivatives?
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Which of the following is a consideration when administering sulfasalazine?
Which of the following is a consideration when administering sulfasalazine?
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What adverse effect should be monitored for in patients receiving corticosteroids?
What adverse effect should be monitored for in patients receiving corticosteroids?
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How should 5-ASA derivatives be administered to ensure efficacy?
How should 5-ASA derivatives be administered to ensure efficacy?
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What is the route of administration for biologic therapies targeting TNF inhibitors?
What is the route of administration for biologic therapies targeting TNF inhibitors?
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Which of the following is a sign of possible infection while on biologic therapies?
Which of the following is a sign of possible infection while on biologic therapies?
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What should be evaluated to determine the therapeutic response to 5-ASA derivatives?
What should be evaluated to determine the therapeutic response to 5-ASA derivatives?
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What is a necessary action when administering corticosteroids?
What is a necessary action when administering corticosteroids?
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Study Notes
5-Aminosalicylic Acid (5-ASA) Derivatives
- Inhibit inflammation in the intestine by blocking leukotrienes and tumor necrosis factor.
- Available orally, as enemas, or suppositories, activated by gut bacteria.
- Contraindications: Sulfa allergy, salicylate allergy, intestinal or urinary tract obstruction.
- Adverse effects: Headache, diarrhea, dizziness, rhinitis, sinusitis, skin rash, and pruritus.
- May interact with heparin, monitor renal and liver function, and complete blood count (CBC).
Corticosteroids
- Suppress the immune system and leukocyte migration.
- Available orally (time-released) or as an enema for topical action.
- Adverse effects: Headache, acne, infections, Cushing disease.
Biologic Therapies: Tumor Necrosis Factor (TNF) Inhibitors
- Block TNFα to reduce intestinal inflammation.
- Monoclonal antibodies administered subcutaneously.
- Immunosuppressant: Monitor for infection and cancer.
- Adverse effects: Headache, skin rash, positive ANA titer, increased creatine phosphokinase.
Integrin Antagonists (Alpha-4 Integrin Inhibitors)
- Prevent leukocyte migration to the intestine by binding to alpha-4 integrin.
- Monoclonal antibodies administered intravenously.
- Immunosuppressant: Monitor for infection.
- Adverse effects: Headache, nausea, fatigue, depression, skin rash.
Interleukin-12/23 Inhibitors
- Block interleukin-12 and interleukin-23, inhibiting natural killer cell and TNF activation.
- Subcutaneous administration, rotate injection sites.
- Immunosuppressant: Monitor for infections, especially TB and fungal.
- Adverse effects: Headache, nausea, fatigue, depression, skin itching.
- Vaccines: No live vaccines, nonlive vaccines may be ineffective.
Janus-Associated Kinase (JAK) Inhibitors
- Inhibit JAK enzymes inside cells suppressing immune cell activity, natural killer cells, immunoglobulins, and B cells.
- Oral administration.
- Adverse effects: Infection.
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Description
Test your knowledge on various anti-inflammatory drugs including 5-Aminosalicylic Acid (5-ASA) derivatives, corticosteroids, and biological therapies like TNF inhibitors. The quiz covers their mechanisms, contraindications, adverse effects, and monitoring requirements. Perfect for students in pharmacology or medicine.
