Pharmacology: Anti-Inflammatory Drugs

What is the effect of increasing the dose of aspirin on its elimination half-life?

It remains constant at 3-5 hours
It decreases from 3-5 hours to 1-2 hours
It increases from 3-5 hours to 12-16 hours (correct)
It becomes zero

What is the primary mechanism of aspirin's anti-inflammatory effect?

Irreversible inhibition of platelet COX
Nonselective inhibition of both COX isoforms (correct)
Selective inhibition of COX-1
Stimulation of interleukin-1

What is the effect of alkalinization of urine on the excretion of salicylate?

It decreases the rate of excretion
It increases the rate of excretion (correct)
It has no effect on the rate of excretion
It makes the excretion rate constant

What is the duration of aspirin's antiplatelet effect?

8-10 days (A) Signup and view all the answers

What is the primary site of action for aspirin's analgesic effect?

Subcortical site (C) Signup and view all the answers

Why is it recommended to administer aspirin with food?

To prevent acidity (D) Signup and view all the answers

What is the primary goal of therapeutic strategies for patients with inflammation?

Relief of pain and maintenance of function (B) Signup and view all the answers

What is the characteristic of Nabumetone in terms of pharmacokinetics?

It is a ketone prodrug that is metabolized to the acidic active drug (B) Signup and view all the answers

What is the result of Phase I reaction in the Arachidonic Acid Pathway?

Conversion of the parent drug to a more polar metabolite, resulting in inactivation, modification, or enhancement (D) Signup and view all the answers

What is the mechanism of action of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?

Inhibition of COX, resulting in decreased prostaglandin production (A) Signup and view all the answers

What is the characteristic of most NSAIDs in terms of pharmacokinetics?

They are weak organic acids, except Nabumetone (C) Signup and view all the answers

What is the classification of Ibuprofen based on its chemistry?

Proprionic acid derivative (D) Signup and view all the answers

What is the primary mechanism of action of NSAIDs in reducing inflammation?

Inhibition of biosynthesis of prostaglandins (A) Signup and view all the answers

Which of the following NSAIDs is provided as a single enantiomer?

Naproxen (D) Signup and view all the answers

What is the most important mode of excretion for NSAIDs?

Renal excretion (A) Signup and view all the answers

Which of the following NSAIDs is associated with a higher risk of myocardial infarction?

Celecoxib (A) Signup and view all the answers

What is the primary reason for the nephrotoxicity of NSAIDs?

Inhibition of autoregulation of renal blood flow (D) Signup and view all the answers

Which of the following is a characteristic of COX2 selective inhibitors?

No effect on platelet function (D) Signup and view all the answers

What is the primary mechanism by which Aspirin inhibits platelet function?

Irreversible acetylation of platelet cyclooxygenase (C) Signup and view all the answers

What is the effect of NSAIDs on lymphokine production from T lymphocytes?

Decrease in lymphokine production (A) Signup and view all the answers

What is the role of CYP3A and CYP2C families of P450 enzymes in NSAID metabolism?

Phase I metabolism (D) Signup and view all the answers

What is the effect of NSAIDs on the incidence of colon cancer?

Decrease in incidence of colon cancer (A) Signup and view all the answers