Pharmacology: Anti-Inflammatory Drugs
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Questions and Answers

What is the effect of increasing the dose of aspirin on its elimination half-life?

  • It remains constant at 3-5 hours
  • It decreases from 3-5 hours to 1-2 hours
  • It increases from 3-5 hours to 12-16 hours (correct)
  • It becomes zero

    • What is the primary mechanism of aspirin's anti-inflammatory effect?

  • Irreversible inhibition of platelet COX
  • Nonselective inhibition of both COX isoforms (correct)
  • Selective inhibition of COX-1
  • Stimulation of interleukin-1

    • What is the effect of alkalinization of urine on the excretion of salicylate?

  • It decreases the rate of excretion
  • It increases the rate of excretion (correct)
  • It has no effect on the rate of excretion
  • It makes the excretion rate constant

    • What is the duration of aspirin's antiplatelet effect?

    <p>8-10 days</p> Signup and view all the answers

    What is the primary site of action for aspirin's analgesic effect?

    <p>Subcortical site</p> Signup and view all the answers

    Why is it recommended to administer aspirin with food?

    <p>To prevent acidity</p> Signup and view all the answers

    What is the primary goal of therapeutic strategies for patients with inflammation?

    <p>Relief of pain and maintenance of function</p> Signup and view all the answers

    What is the characteristic of Nabumetone in terms of pharmacokinetics?

    <p>It is a ketone prodrug that is metabolized to the acidic active drug</p> Signup and view all the answers

    What is the result of Phase I reaction in the Arachidonic Acid Pathway?

    <p>Conversion of the parent drug to a more polar metabolite, resulting in inactivation, modification, or enhancement</p> Signup and view all the answers

    What is the mechanism of action of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?

    <p>Inhibition of COX, resulting in decreased prostaglandin production</p> Signup and view all the answers

    What is the characteristic of most NSAIDs in terms of pharmacokinetics?

    <p>They are weak organic acids, except Nabumetone</p> Signup and view all the answers

    What is the classification of Ibuprofen based on its chemistry?

    <p>Proprionic acid derivative</p> Signup and view all the answers

    What is the primary mechanism of action of NSAIDs in reducing inflammation?

    <p>Inhibition of biosynthesis of prostaglandins</p> Signup and view all the answers

    Which of the following NSAIDs is provided as a single enantiomer?

    <p>Naproxen</p> Signup and view all the answers

    What is the most important mode of excretion for NSAIDs?

    <p>Renal excretion</p> Signup and view all the answers

    Which of the following NSAIDs is associated with a higher risk of myocardial infarction?

    <p>Celecoxib</p> Signup and view all the answers

    What is the primary reason for the nephrotoxicity of NSAIDs?

    <p>Inhibition of autoregulation of renal blood flow</p> Signup and view all the answers

    Which of the following is a characteristic of COX2 selective inhibitors?

    <p>No effect on platelet function</p> Signup and view all the answers

    What is the primary mechanism by which Aspirin inhibits platelet function?

    <p>Irreversible acetylation of platelet cyclooxygenase</p> Signup and view all the answers

    What is the effect of NSAIDs on lymphokine production from T lymphocytes?

    <p>Decrease in lymphokine production</p> Signup and view all the answers

    What is the role of CYP3A and CYP2C families of P450 enzymes in NSAID metabolism?

    <p>Phase I metabolism</p> Signup and view all the answers

    What is the effect of NSAIDs on the incidence of colon cancer?

    <p>Decrease in incidence of colon cancer</p> Signup and view all the answers

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