22 Questions
What is the effect of increasing the dose of aspirin on its elimination half-life?
It increases from 3-5 hours to 12-16 hours
What is the primary mechanism of aspirin's anti-inflammatory effect?
Nonselective inhibition of both COX isoforms
What is the effect of alkalinization of urine on the excretion of salicylate?
It increases the rate of excretion
What is the duration of aspirin's antiplatelet effect?
8-10 days
What is the primary site of action for aspirin's analgesic effect?
Subcortical site
Why is it recommended to administer aspirin with food?
To prevent acidity
What is the primary goal of therapeutic strategies for patients with inflammation?
Relief of pain and maintenance of function
What is the characteristic of Nabumetone in terms of pharmacokinetics?
It is a ketone prodrug that is metabolized to the acidic active drug
What is the result of Phase I reaction in the Arachidonic Acid Pathway?
Conversion of the parent drug to a more polar metabolite, resulting in inactivation, modification, or enhancement
What is the mechanism of action of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)?
Inhibition of COX, resulting in decreased prostaglandin production
What is the characteristic of most NSAIDs in terms of pharmacokinetics?
They are weak organic acids, except Nabumetone
What is the classification of Ibuprofen based on its chemistry?
Proprionic acid derivative
What is the primary mechanism of action of NSAIDs in reducing inflammation?
Inhibition of biosynthesis of prostaglandins
Which of the following NSAIDs is provided as a single enantiomer?
Naproxen
What is the most important mode of excretion for NSAIDs?
Renal excretion
Which of the following NSAIDs is associated with a higher risk of myocardial infarction?
Celecoxib
What is the primary reason for the nephrotoxicity of NSAIDs?
Inhibition of autoregulation of renal blood flow
Which of the following is a characteristic of COX2 selective inhibitors?
No effect on platelet function
What is the primary mechanism by which Aspirin inhibits platelet function?
Irreversible acetylation of platelet cyclooxygenase
What is the effect of NSAIDs on lymphokine production from T lymphocytes?
Decrease in lymphokine production
What is the role of CYP3A and CYP2C families of P450 enzymes in NSAID metabolism?
Phase I metabolism
What is the effect of NSAIDs on the incidence of colon cancer?
Decrease in incidence of colon cancer
Test your knowledge of glucocorticoids, disease-modifying anti-rheumatic drugs, and non-steroidal anti-inflammatory drugs (NSAIDs). This quiz covers the classification and characteristics of different types of NSAIDs, including aspirin and COX inhibitors.
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