Pharmacology Anti-Cancer Lec 11 Quiz
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Questions and Answers

How do anthracyclines induce cytotoxicity?

  • By inducing DNA strand scission (correct)
  • By enhancing blood-brain barrier penetration
  • By promoting biliary excretion
  • By increasing plasma protein levels

    • Why must anthracycline antibiotics be administered intravenously?

  • To reduce plasma protein binding
  • To minimize tissue necrosis
  • Because they are inactivated in the GI tract (correct)
  • To enhance biliary excretion

    • Which major route of elimination is followed by anthracycline antibiotics?

  • Biliary excretion (correct)
  • Renal excretion
  • Fecal excretion
  • Pulmonary excretion

    • What issue can extravasation of anthracycline antibiotics lead to?

    <p>Tissue necrosis</p> Signup and view all the answers

    Which organs do anthracycline antibiotics not penetrate?

    <p>Blood-brain barrier and testes</p> Signup and view all the answers

    Which anthracycline antibiotic is associated with more serious dose-dependent cardiotoxicity?

    <p>Daunorubicin</p> Signup and view all the answers

    Which type of cancer is bleomycin primarily used in the treatment of?

    <p>Testicular cancers</p> Signup and view all the answers

    What is the most serious adverse effect associated with bleomycin?

    <p>Pulmonary toxicity</p> Signup and view all the answers

    What is the mechanism of action of bleomycin on DNA?

    <p>Inducing oxidative process leading to strand breakage</p> Signup and view all the answers

    How does dexrazoxane protect against the cardiotoxicity of doxorubicin?

    <p>By acting as an iron chelator</p> Signup and view all the answers

    Where is the bleomycin-inactivating enzyme high, leading to potential toxicity?

    <p>Liver</p> Signup and view all the answers

    What happens when a DNA–bleomycin–Fe2+ complex undergoes oxidation?

    <p>Formation of bleomycin–Fe3+</p> Signup and view all the answers

    What is the primary mechanism of action of antitumor antibiotics like anthracyclines?

    <p>Inhibition of topoisomerases</p> Signup and view all the answers

    Which of the following is NOT classified as an anthracycline antibiotic?

    <p>Epinephrine</p> Signup and view all the answers

    In contrast to other antitumor antibiotics, which anthracycline antibiotic is cell cycle specific?

    <p>Daunorubicin</p> Signup and view all the answers

    Which type of cancer is Doxorubicin commonly used to treat?

    <p>Breast cancer</p> Signup and view all the answers

    Apart from intercalation with DNA, which other mechanism contributes to the cytotoxic effect of antitumor antibiotics?

    <p>Inhibition of microtubule assembly</p> Signup and view all the answers

    Which anthracycline antibiotic is the hydroxylated analog of Daunorubicin?

    <p>Doxorubicin</p> Signup and view all the answers

    What is the mechanism of action of Vinca alkaloids in anti-cancer pharmacology?

    <p>Freezing the spindle apparatus in metaphase</p> Signup and view all the answers

    Which adverse effects are more common with VBL compared to VX in anti-cancer pharmacology?

    <p>Peripheral neuropathy and constipation</p> Signup and view all the answers

    How are Vinca alkaloids metabolized and eliminated in the body?

    <p>Metabolized in the liver via CYP450 pathway and eliminated in bile and feces</p> Signup and view all the answers

    What can result from IV injection of anti-cancer agents according to the text?

    <p>Hyperuricemia</p> Signup and view all the answers

    Why is it crucial not to administer Vinca alkaloids intrathecally?

    <p>Risk of central nervous system toxicity</p> Signup and view all the answers

    What distinguishes docetaxel from paclitaxel in anti-cancer pharmacology?

    <p>Presence of a side chain substitution</p> Signup and view all the answers

    What is the mechanism of action of paclitaxel and docetaxel in treating cancer?

    <p>Promote polymerization and stabilization of microtubules</p> Signup and view all the answers

    Which phase of the cell cycle are paclitaxel and docetaxel active in?

    <p>G2/M</p> Signup and view all the answers

    How are paclitaxel and docetaxel metabolized in the body?

    <p>Metabolized by the CYP450 system</p> Signup and view all the answers

    What is the common adverse effect associated with paclitaxel and docetaxel?

    <p>Peripheral neuropathy</p> Signup and view all the answers

    How should patients be premedicated before receiving paclitaxel to prevent hypersensitivity reactions?

    <p>Corticosteroids and antihistamines</p> Signup and view all the answers

    What are the dose-limiting toxicities of paclitaxel and docetaxel?

    <p>Neutropenia and leukopenia</p> Signup and view all the answers

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