Podcast
Questions and Answers
How do anthracyclines induce cytotoxicity?
How do anthracyclines induce cytotoxicity?
- By inducing DNA strand scission (correct)
- By enhancing blood-brain barrier penetration
- By promoting biliary excretion
- By increasing plasma protein levels
Why must anthracycline antibiotics be administered intravenously?
Why must anthracycline antibiotics be administered intravenously?
- To reduce plasma protein binding
- To minimize tissue necrosis
- Because they are inactivated in the GI tract (correct)
- To enhance biliary excretion
Which major route of elimination is followed by anthracycline antibiotics?
Which major route of elimination is followed by anthracycline antibiotics?
- Biliary excretion (correct)
- Renal excretion
- Fecal excretion
- Pulmonary excretion
What issue can extravasation of anthracycline antibiotics lead to?
What issue can extravasation of anthracycline antibiotics lead to?
Which organs do anthracycline antibiotics not penetrate?
Which organs do anthracycline antibiotics not penetrate?
Which anthracycline antibiotic is associated with more serious dose-dependent cardiotoxicity?
Which anthracycline antibiotic is associated with more serious dose-dependent cardiotoxicity?
Which type of cancer is bleomycin primarily used in the treatment of?
Which type of cancer is bleomycin primarily used in the treatment of?
What is the most serious adverse effect associated with bleomycin?
What is the most serious adverse effect associated with bleomycin?
What is the mechanism of action of bleomycin on DNA?
What is the mechanism of action of bleomycin on DNA?
How does dexrazoxane protect against the cardiotoxicity of doxorubicin?
How does dexrazoxane protect against the cardiotoxicity of doxorubicin?
Where is the bleomycin-inactivating enzyme high, leading to potential toxicity?
Where is the bleomycin-inactivating enzyme high, leading to potential toxicity?
What happens when a DNA–bleomycin–Fe2+ complex undergoes oxidation?
What happens when a DNA–bleomycin–Fe2+ complex undergoes oxidation?
What is the primary mechanism of action of antitumor antibiotics like anthracyclines?
What is the primary mechanism of action of antitumor antibiotics like anthracyclines?
Which of the following is NOT classified as an anthracycline antibiotic?
Which of the following is NOT classified as an anthracycline antibiotic?
In contrast to other antitumor antibiotics, which anthracycline antibiotic is cell cycle specific?
In contrast to other antitumor antibiotics, which anthracycline antibiotic is cell cycle specific?
Which type of cancer is Doxorubicin commonly used to treat?
Which type of cancer is Doxorubicin commonly used to treat?
Apart from intercalation with DNA, which other mechanism contributes to the cytotoxic effect of antitumor antibiotics?
Apart from intercalation with DNA, which other mechanism contributes to the cytotoxic effect of antitumor antibiotics?
Which anthracycline antibiotic is the hydroxylated analog of Daunorubicin?
Which anthracycline antibiotic is the hydroxylated analog of Daunorubicin?
What is the mechanism of action of Vinca alkaloids in anti-cancer pharmacology?
What is the mechanism of action of Vinca alkaloids in anti-cancer pharmacology?
Which adverse effects are more common with VBL compared to VX in anti-cancer pharmacology?
Which adverse effects are more common with VBL compared to VX in anti-cancer pharmacology?
How are Vinca alkaloids metabolized and eliminated in the body?
How are Vinca alkaloids metabolized and eliminated in the body?
What can result from IV injection of anti-cancer agents according to the text?
What can result from IV injection of anti-cancer agents according to the text?
Why is it crucial not to administer Vinca alkaloids intrathecally?
Why is it crucial not to administer Vinca alkaloids intrathecally?
What distinguishes docetaxel from paclitaxel in anti-cancer pharmacology?
What distinguishes docetaxel from paclitaxel in anti-cancer pharmacology?
What is the mechanism of action of paclitaxel and docetaxel in treating cancer?
What is the mechanism of action of paclitaxel and docetaxel in treating cancer?
Which phase of the cell cycle are paclitaxel and docetaxel active in?
Which phase of the cell cycle are paclitaxel and docetaxel active in?
How are paclitaxel and docetaxel metabolized in the body?
How are paclitaxel and docetaxel metabolized in the body?
What is the common adverse effect associated with paclitaxel and docetaxel?
What is the common adverse effect associated with paclitaxel and docetaxel?
How should patients be premedicated before receiving paclitaxel to prevent hypersensitivity reactions?
How should patients be premedicated before receiving paclitaxel to prevent hypersensitivity reactions?
What are the dose-limiting toxicities of paclitaxel and docetaxel?
What are the dose-limiting toxicities of paclitaxel and docetaxel?
