Pharmacology: Acetaminophen

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Questions and Answers

What is the classification of Vasopressin?

Hormone / Vasoconstrictor

Blanching of skin, Hypertension, and Bradycardia are common side effects of ____.

Vecuronium / Norcuron

Which of the following are indications for administering Vasopressin? (Select all that apply)

  • Multisystem trauma
  • Cardiac arrest (correct)
  • RSI
  • Neuromuscular block

Vasopressin is a potent vasoconstrictor. True or False?

<p>True (A)</p> Signup and view all the answers

Match the drug with its primary indication:

<p>Vasopressin = Hormone / Vasoconstrictor Vecuronium / Norcuron = RSI</p> Signup and view all the answers

What is the classification of Acetaminophen/Tylenol?

<p>Non-narcotic analgesic/antipyretic</p> Signup and view all the answers

Acetaminophen inhibits ________.

<p>Cyclooxygenase</p> Signup and view all the answers

What is the recommended dose range for Acetaminophen/Tylenol every 4-6 hours?

<p>325-650 mg (A)</p> Signup and view all the answers

Hypotension is a contraindication for Norepinephrine/Levophed.

<p>False (B)</p> Signup and view all the answers

Match the following drugs with their classifications:

<p>Succinylcholine/Anectine = Neuromuscular blocking agent Tranexamic Acid/TXA = Anti-fibrinolytics Norepinephrine/Levophed = Sympathomimetic</p> Signup and view all the answers

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Study Notes

Acetaminophen / Tylenol

  • Classification: Non-narcotic analgesic and antipyretic
  • Action: Inhibits cyclooxygenase
  • Indications: Mild pain, moderate pain, and fever
  • Dose and Route:
    • 325-650 mg every 4-6 hours (oral)
    • 650-1000 mg IV (intravenous)
    • 1 gram (associated with nausea)
    • PED: 10-15mg/kg every 4-6 hours
  • Warnings and Interactions:
    • Use with caution in children
    • Monitor BP (blood pressure)
    • Syncope (fainting) can occur
    • If hypotension occurs, immediately wipe paste off
  • Side Effects: Hypotension, dizziness

Norepinephrine / Levophed

  • Classification: Sympathomimetic
  • Action: Causes peripheral vasoconstriction
  • Indications:
    • Systolic BP < 0.5 mEq/kg
    • Hyperventilation
    • Cardiac arrest
    • Hyperkalemia
  • Dose and Route:
    • Every 10 minutes
  • Warnings and Interactions:
    • Delivers large sodium load
    • Can deactivate catecholamines
  • Side Effects: Alkalosis

Succinylcholine / Anectine

  • Classification: Neuromuscular blocking agent (depolarizing)
  • Action: Skeletal muscle relaxer
  • Indications: RSI (rapid sequence intubation)
  • Dose and Route:
    • 1-1.5 mg/kg IV
    • 40-100 mg
  • Warnings and Interactions:
    • Paralysis occurs within 1 minute and lasts 8 minutes
  • Side Effects: Hypotension, bradycardia, prolongs paralysis

Tranexamic Acid / TXA

  • Classification: Anti-fibrinolytic
  • Action: Promotes clotting factor
  • Indications: Multisystem trauma
  • Dose and Route:
    • 1-2g over 10 minutes
  • Warnings and Interactions:
    • Contraindicated in brain bleed
  • Side Effects: Nausea, vomiting, diarrhea, muscle pain

Vasopressin

  • Classification: Hormone / Vasoconstrictor
  • Action:
    • Antidiuretic hormone
    • Potent vasoconstrictor
  • Indications: Cardiac arrest
  • Dose and Route:
    • 40 Units IV (single dose)
  • Warnings and Interactions: None in the emergency setting
  • Side Effects: Blanching of skin, hypertension, bradycardia

Vecuronium / Norcuron

  • Classification: Neuromuscular block agent (non-depolarizing)
  • Action:
    • Skeletal muscle relaxant
    • Paralyzes respiratory muscle
  • Indications: RSI
  • Dose and Route:
    • 0.08-0.1 mg/kg IV
    • Pediatric: 0.1 mg/kg IV
  • Warnings and Interactions:
    • ET intubation must be ready immediately
    • Effect within 1 minute and lasts 30 minutes
  • Side Effects: Prolonged paralysis, hypotension, bradycardia

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