Pharmacological Management of Hypertriglyceridemia and Atherosclerosis
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Questions and Answers

Which drug is used as monotherapy in hypertriglyceridemia and combined with statins in mixed dyslipidemia?

  • Omega-3 Fatty Acids
  • Statins
  • Fibrates (correct)
  • Niacin

What is the primary mechanism through which Omega-3 Fatty Acids protect cell membranes?

  • Inhibition of platelet aggregation
  • Protection against oxidative stress (correct)
  • Inhibition of hormone sensitive lipase
  • Activation of lipoprotein lipase

Which drug decreases lipolysis and availability of free fatty acids for triglyceride synthesis in the liver?

  • Fibrates
  • Niacin (correct)
  • Omega-3 Fatty Acids
  • Statins

How do Fibrates improve glucose tolerance and suppress serum uric acid?

<p>By activating PPAR-α receptors (A)</p> Signup and view all the answers

Which drug is the best for elevating HDL levels?

<p>Niacin (C)</p> Signup and view all the answers

Why are Fibrates never given during pregnancy and used cautiously in renal and hepatic impairment?

<p>Due to potential risks to the fetus and patients with impaired renal and hepatic function (C)</p> Signup and view all the answers

What is a major issue associated with the use of niacin in the treatment of dyslipidemias?

<p>Elevation of blood glucose and uric acid levels (C)</p> Signup and view all the answers

Which symptom can be avoided when using niacin by taking aspirin an hour before its intake?

<p>Flushing (A)</p> Signup and view all the answers

How does cholestyramine aid in lowering hypertriglyceridemia?

<p>By adsorbing bile acids and eliminating them in stools (D)</p> Signup and view all the answers

What is the main purpose of using aspirin alongside niacin therapy?

<p>To alleviate the side effect of flushing (A)</p> Signup and view all the answers

Which adverse effect limits the use of niacin in patients with gout?

<p>Increase in uric acid levels (B)</p> Signup and view all the answers

Which of the following best describes the mechanism of action of fibrates?

<p>Fibrates act as PPAR-α agonists, modulating gene expression related to lipoprotein metabolism, fatty acid oxidation, and inflammation. (D)</p> Signup and view all the answers

What is the primary mechanism by which omega-3 fatty acids lower triglyceride levels?

<p>Decreased hepatic production of VLDL particles. (A)</p> Signup and view all the answers

Which of the following is the primary mechanism by which niacin (nicotinic acid) raises HDL-C levels?

<p>Upregulation of the ABCA1 transporter, promoting cholesterol efflux. (C)</p> Signup and view all the answers

In the treatment of hypertriglyceridemia in diabetic patients, which lipid-lowering agent is considered the drug of choice?

<p>Fibrates (D)</p> Signup and view all the answers

Which of the following statements regarding the use of statins is correct?

<p>Statins are given during or following acute ischemic events like myocardial infarction and stroke. (C)</p> Signup and view all the answers

Which of the following statements regarding ezetimibe is correct?

<p>Ezetimibe is a selective inhibitor of the cholesterol absorption transporter NPC1L1. (A)</p> Signup and view all the answers

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