17 Questions
Which drug is used as monotherapy in hypertriglyceridemia and combined with statins in mixed dyslipidemia?
Fibrates
What is the primary mechanism through which Omega-3 Fatty Acids protect cell membranes?
Protection against oxidative stress
Which drug decreases lipolysis and availability of free fatty acids for triglyceride synthesis in the liver?
Niacin
How do Fibrates improve glucose tolerance and suppress serum uric acid?
By activating PPAR-α receptors
Which drug is the best for elevating HDL levels?
Niacin
Why are Fibrates never given during pregnancy and used cautiously in renal and hepatic impairment?
Due to potential risks to the fetus and patients with impaired renal and hepatic function
What is a major issue associated with the use of niacin in the treatment of dyslipidemias?
Elevation of blood glucose and uric acid levels
Which symptom can be avoided when using niacin by taking aspirin an hour before its intake?
Flushing
How does cholestyramine aid in lowering hypertriglyceridemia?
By adsorbing bile acids and eliminating them in stools
What is the main purpose of using aspirin alongside niacin therapy?
To alleviate the side effect of flushing
Which adverse effect limits the use of niacin in patients with gout?
Increase in uric acid levels
Which of the following best describes the mechanism of action of fibrates?
Fibrates act as PPAR-α agonists, modulating gene expression related to lipoprotein metabolism, fatty acid oxidation, and inflammation.
What is the primary mechanism by which omega-3 fatty acids lower triglyceride levels?
Decreased hepatic production of VLDL particles.
Which of the following is the primary mechanism by which niacin (nicotinic acid) raises HDL-C levels?
Upregulation of the ABCA1 transporter, promoting cholesterol efflux.
In the treatment of hypertriglyceridemia in diabetic patients, which lipid-lowering agent is considered the drug of choice?
Fibrates
Which of the following statements regarding the use of statins is correct?
Statins are given during or following acute ischemic events like myocardial infarction and stroke.
Which of the following statements regarding ezetimibe is correct?
Ezetimibe is a selective inhibitor of the cholesterol absorption transporter NPC1L1.
This quiz covers the pharmacological management of hypertriglyceridemia in diabetics and atherosclerosis, focusing on the use of statins and ezetimibe. It also discusses the contraindications and precautions associated with these medications.
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