Pharmacokinetics Quiz: Absorption and Elimination
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Questions and Answers

What does Ka represent in drug absorption kinetics?

  • Rate of absorption
  • Amount of drug available at the site of absorption
  • Absorption rate constant (correct)
  • Rate of elimination
  • In absorption kinetics, what is the rate of absorption proportional to?

  • Amount of drug available at the site of absorption (Xa) (correct)
  • Rate of elimination
  • Amount of drug in plasma (X)
  • Difference between absorption and elimination rates
  • Which process is involved in drug absorption in the gastrointestinal tract?

  • Excretion through the kidneys
  • Gastric emptying and GI motility (correct)
  • Conversion in the respiratory system
  • Metabolism in the liver
  • What is a common method by which drugs are transported across epithelial membranes into systemic circulation?

    <p>Active transport</p> Signup and view all the answers

    Which factor is challenging to measure directly in absorption kinetics?

    <p>Amount of drug at the site of absorption (Xa)</p> Signup and view all the answers

    What does the rate of change (dX/dt) represent in the drug absorption rate model?

    <p>Difference between absorption and elimination rates</p> Signup and view all the answers

    When assuming first-order kinetics, what is the rate of absorption proportional to?

    <p>Absorption rate constant Ka</p> Signup and view all the answers

    Which parameter represents the rate at which a drug is absorbed from the site of administration?

    <p>(dXa/dt) = Ka * Xa</p> Signup and view all the answers

    'Passive diffusion' as a method for drug transport refers to:

    <p>Movement from an area of high concentration to low concentration without energy input</p> Signup and view all the answers

    Which phase of drug elimination shows a linear time curve on a semi-log scale?

    <p>Elimination phase</p> Signup and view all the answers

    From which curve is the Ke value more accurate for IV bolus dosing?

    <p>PK curve for IV bolus dosing</p> Signup and view all the answers

    What method is used to determine the absorption rate constant (ka) in drug kinetics?

    <p>Feathering method</p> Signup and view all the answers

    Which parameter can be obtained after determining the slope following the terminal phase error?

    <p>Ke</p> Signup and view all the answers

    In absorption kinetics, what is the constant represented by logC4 during back calculation before Tmax?

    <p>Ke*t4</p> Signup and view all the answers

    What does the LnCp equation represent in drug kinetics?

    <p>Elimination phase equation</p> Signup and view all the answers

    Which method involves finding the equation for the elimination phase from the semi-log concentration vs. time graph?

    <p>Least residual method</p> Signup and view all the answers

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