Pharmacokinetics Quiz: Absorption and Elimination

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Questions and Answers

What does Ka represent in drug absorption kinetics?

  • Rate of absorption
  • Amount of drug available at the site of absorption
  • Absorption rate constant (correct)
  • Rate of elimination

In absorption kinetics, what is the rate of absorption proportional to?

  • Amount of drug available at the site of absorption (Xa) (correct)
  • Rate of elimination
  • Amount of drug in plasma (X)
  • Difference between absorption and elimination rates

Which process is involved in drug absorption in the gastrointestinal tract?

  • Excretion through the kidneys
  • Gastric emptying and GI motility (correct)
  • Conversion in the respiratory system
  • Metabolism in the liver

What is a common method by which drugs are transported across epithelial membranes into systemic circulation?

<p>Active transport (C)</p> Signup and view all the answers

Which factor is challenging to measure directly in absorption kinetics?

<p>Amount of drug at the site of absorption (Xa) (B)</p> Signup and view all the answers

What does the rate of change (dX/dt) represent in the drug absorption rate model?

<p>Difference between absorption and elimination rates (C)</p> Signup and view all the answers

When assuming first-order kinetics, what is the rate of absorption proportional to?

<p>Absorption rate constant Ka (A)</p> Signup and view all the answers

Which parameter represents the rate at which a drug is absorbed from the site of administration?

<p>(dXa/dt) = Ka * Xa (D)</p> Signup and view all the answers

'Passive diffusion' as a method for drug transport refers to:

<p>Movement from an area of high concentration to low concentration without energy input (B)</p> Signup and view all the answers

Which phase of drug elimination shows a linear time curve on a semi-log scale?

<p>Elimination phase (B)</p> Signup and view all the answers

From which curve is the Ke value more accurate for IV bolus dosing?

<p>PK curve for IV bolus dosing (C)</p> Signup and view all the answers

What method is used to determine the absorption rate constant (ka) in drug kinetics?

<p>Feathering method (A)</p> Signup and view all the answers

Which parameter can be obtained after determining the slope following the terminal phase error?

<p>Ke (A)</p> Signup and view all the answers

In absorption kinetics, what is the constant represented by logC4 during back calculation before Tmax?

<p>Ke*t4 (B)</p> Signup and view all the answers

What does the LnCp equation represent in drug kinetics?

<p>Elimination phase equation (A)</p> Signup and view all the answers

Which method involves finding the equation for the elimination phase from the semi-log concentration vs. time graph?

<p>Least residual method (A)</p> Signup and view all the answers

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