Pharmacokinetics Quiz: Absorption and Elimination

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What does Ka represent in drug absorption kinetics?

Rate of absorption

Amount of drug available at the site of absorption

Absorption rate constant (correct)

Rate of elimination

In absorption kinetics, what is the rate of absorption proportional to?

Amount of drug available at the site of absorption (Xa) (correct)

Rate of elimination

Amount of drug in plasma (X)

Difference between absorption and elimination rates

Which process is involved in drug absorption in the gastrointestinal tract?

Excretion through the kidneys

Gastric emptying and GI motility (correct)

Conversion in the respiratory system

Metabolism in the liver

What is a common method by which drugs are transported across epithelial membranes into systemic circulation?

Active transport Signup and view all the answers

Which factor is challenging to measure directly in absorption kinetics?

Amount of drug at the site of absorption (Xa) Signup and view all the answers

What does the rate of change (dX/dt) represent in the drug absorption rate model?

Difference between absorption and elimination rates Signup and view all the answers

When assuming first-order kinetics, what is the rate of absorption proportional to?

Absorption rate constant Ka Signup and view all the answers

Which parameter represents the rate at which a drug is absorbed from the site of administration?

(dXa/dt) = Ka * Xa Signup and view all the answers

'Passive diffusion' as a method for drug transport refers to:

Movement from an area of high concentration to low concentration without energy input Signup and view all the answers

Which phase of drug elimination shows a linear time curve on a semi-log scale?

Elimination phase Signup and view all the answers

From which curve is the Ke value more accurate for IV bolus dosing?

PK curve for IV bolus dosing Signup and view all the answers

What method is used to determine the absorption rate constant (ka) in drug kinetics?

Feathering method Signup and view all the answers

Which parameter can be obtained after determining the slope following the terminal phase error?

Ke Signup and view all the answers

In absorption kinetics, what is the constant represented by logC4 during back calculation before Tmax?

Ke*t4 Signup and view all the answers

What does the LnCp equation represent in drug kinetics?

Elimination phase equation Signup and view all the answers

Which method involves finding the equation for the elimination phase from the semi-log concentration vs. time graph?

Least residual method Signup and view all the answers

Pharmacokinetics Quiz: Absorption and Elimination

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