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Questions and Answers
What is the equation for estimating the elimination rate constant (k) in aminoglycosides?
What is the equation for estimating the elimination rate constant (k) in aminoglycosides?
- k = 0.00293(CrCl) + 0.014 (correct)
- k = 0.00093(CrCl) + 0.014
- k = 0.0293(CrCl) - 0.014
- k = 0.0093(CrCl) - 0.014
What is the unit of the elimination rate constant (k)?
What is the unit of the elimination rate constant (k)?
- ng/mL
- mL/min
- h-1 (correct)
- L/kg
What is the estimated volume of distribution (VD) for aminoglycosides?
What is the estimated volume of distribution (VD) for aminoglycosides?
- 0.34 L/kg
- 0.44 L/kg
- 0.24 L/kg (correct)
- 0.14 L/kg
What is the purpose of estimating the elimination rate constant (k) and volume of distribution (VD) in aminoglycosides?
What is the purpose of estimating the elimination rate constant (k) and volume of distribution (VD) in aminoglycosides?
Why is creatinine clearance not equal to aminoglycoside clearance?
Why is creatinine clearance not equal to aminoglycoside clearance?
What is the principle used to describe the cumulative effect of multiple doses of aminoglycosides?
What is the principle used to describe the cumulative effect of multiple doses of aminoglycosides?
What is the purpose of infusing drugs over a longer period of time, typically 30-60 minutes?
What is the purpose of infusing drugs over a longer period of time, typically 30-60 minutes?
What is the unit of measurement for the drug infusion rate (R) in the equation Cpeak,ss = R / (Vd * k)?
What is the unit of measurement for the drug infusion rate (R) in the equation Cpeak,ss = R / (Vd * k)?
What is the population estimate for the volume of distribution (VD) for aminoglycosides?
What is the population estimate for the volume of distribution (VD) for aminoglycosides?
What is the elimination rate constant (k) calculated from in the given equation?
What is the elimination rate constant (k) calculated from in the given equation?
What is the desired or most appropriate dosing interval (Ï„) in the given case, rounded down to a practical value?
What is the desired or most appropriate dosing interval (Ï„) in the given case, rounded down to a practical value?
What is the unit of measurement for the desired peak concentration at steady state (Cpeak,ss) in the equation?
What is the unit of measurement for the desired peak concentration at steady state (Cpeak,ss) in the equation?
What is the patient's elimination rate constant (k) calculated from Cpeak and Ctrough values?
What is the patient's elimination rate constant (k) calculated from Cpeak and Ctrough values?
What is the patient's volume of distribution (VD) calculated from Cpeak and Ctrough values?
What is the patient's volume of distribution (VD) calculated from Cpeak and Ctrough values?
What is the relationship between the elimination rate constant (k) and the half-life (t0.5)?
What is the relationship between the elimination rate constant (k) and the half-life (t0.5)?
What is the patient's half-life (t0.5) calculated from Cpeak and Ctrough values?
What is the patient's half-life (t0.5) calculated from Cpeak and Ctrough values?
What is the equation to calculate the patient's Cpeak,ss?
What is the equation to calculate the patient's Cpeak,ss?
What is the unit of the drug infusion rate (R) in the equation to calculate Cpeak,ss?
What is the unit of the drug infusion rate (R) in the equation to calculate Cpeak,ss?
