18 Questions
What is the equation for estimating the elimination rate constant (k) in aminoglycosides?
k = 0.00293(CrCl) + 0.014
What is the unit of the elimination rate constant (k)?
h-1
What is the estimated volume of distribution (VD) for aminoglycosides?
0.24 L/kg
What is the purpose of estimating the elimination rate constant (k) and volume of distribution (VD) in aminoglycosides?
To determine the initial maintenance dose and dosing interval
Why is creatinine clearance not equal to aminoglycoside clearance?
Because some amount of aminoglycoside is eliminated by organs other than the kidneys
What is the principle used to describe the cumulative effect of multiple doses of aminoglycosides?
The principle of superposition
What is the purpose of infusing drugs over a longer period of time, typically 30-60 minutes?
To reduce the risk of adverse effects
What is the unit of measurement for the drug infusion rate (R) in the equation Cpeak,ss = R / (Vd * k)?
Milligrams per hour
What is the population estimate for the volume of distribution (VD) for aminoglycosides?
0.24 L/kg (IBW)
What is the elimination rate constant (k) calculated from in the given equation?
0.00293(CrCl) + 0.014
What is the desired or most appropriate dosing interval (τ) in the given case, rounded down to a practical value?
12 h
What is the unit of measurement for the desired peak concentration at steady state (Cpeak,ss) in the equation?
Milligrams per liter
What is the patient's elimination rate constant (k) calculated from Cpeak and Ctrough values?
0.1445 h^-1
What is the patient's volume of distribution (VD) calculated from Cpeak and Ctrough values?
12.48 L
What is the relationship between the elimination rate constant (k) and the half-life (t0.5)?
k = 0.693 / t0.5
What is the patient's half-life (t0.5) calculated from Cpeak and Ctrough values?
4.796 h
What is the equation to calculate the patient's Cpeak,ss?
Cpeak,ss = R / (k * Vd)
What is the unit of the drug infusion rate (R) in the equation to calculate Cpeak,ss?
milligrams per hour
This quiz covers the concept of peak and trough concentrations in pharmacokinetics, including the principle of superposition and the calculation of peak and trough values. It's essential for understanding drug dosing and elimination.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
