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Questions and Answers
What is the effect of drug concentration on absorption?
What is the effect of drug concentration on absorption?
Which dosage form is likely to be absorbed the fastest?
Which dosage form is likely to be absorbed the fastest?
Which route of administration has no absorption process?
Which route of administration has no absorption process?
Which type of administration allows drugs to undergo alterations before reaching the action site?
Which type of administration allows drugs to undergo alterations before reaching the action site?
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What factor does NOT significantly influence the absorption of drugs?
What factor does NOT significantly influence the absorption of drugs?
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What does bioavailability represent in pharmacology?
What does bioavailability represent in pharmacology?
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What is the primary method for measuring bioavailability?
What is the primary method for measuring bioavailability?
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Which factor does NOT affect bioavailability?
Which factor does NOT affect bioavailability?
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What is meant by absolute bioavailability?
What is meant by absolute bioavailability?
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What is the bioavailability of intravenous (IV) administration?
What is the bioavailability of intravenous (IV) administration?
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What is the primary focus of pharmacokinetics?
What is the primary focus of pharmacokinetics?
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Which of the following processes occurs after drug liberation?
Which of the following processes occurs after drug liberation?
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What is absorption defined as in pharmacokinetics?
What is absorption defined as in pharmacokinetics?
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Which term describes the transformation of compounds into metabolites?
Which term describes the transformation of compounds into metabolites?
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What does the distribution phase involve?
What does the distribution phase involve?
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Which statement about liberation is correct?
Which statement about liberation is correct?
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What is excretion in the context of pharmacokinetics?
What is excretion in the context of pharmacokinetics?
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Which dosage forms do not undergo the liberation process?
Which dosage forms do not undergo the liberation process?
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What is the primary disadvantage of the parenteral route of administration compared to the oral route?
What is the primary disadvantage of the parenteral route of administration compared to the oral route?
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Which statement about oral administration is NOT true?
Which statement about oral administration is NOT true?
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Which route of administration has the fastest onset of action?
Which route of administration has the fastest onset of action?
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What factor promotes better absorption of drugs taken orally?
What factor promotes better absorption of drugs taken orally?
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Which of the following drugs should be administered sublingually for effective results?
Which of the following drugs should be administered sublingually for effective results?
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What is a consequence of using a topical route for drug administration?
What is a consequence of using a topical route for drug administration?
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Which of these routes involves the least absorption modification from external factors?
Which of these routes involves the least absorption modification from external factors?
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What does bioavailability primarily represent in pharmacokinetics?
What does bioavailability primarily represent in pharmacokinetics?
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Study Notes
Pharmacokinetics
- Pharmacokinetics is a branch of pharmacology that studies how drugs are absorbed, distributed, metabolized, and excreted within the body.
- The fate of the drug within the organism is determined by time and dose.
- Liberation is the process of the drug being released from the formulation.
- Liberation ends with the drug dissolving, making it ready to be absorbed.
- All dosage forms, except those administered as a solution, undergo liberation.
- Absorption involves the drug entering the bloodstream from the administration site.
- Drugs must cross biological membranes. Absorption is affected by solubility, concentration, absorption surface area, blood flow at the absorption surface, and administration route.
- Absorption is affected by the Concentration of a drug: A concentrated solution is absorbed faster than a diluted solution.
- Absorption is affected by the Dosage form: Liquid forms are absorbed faster than solid forms, smaller particles are absorbed more easily.
- IV drugs skip the absorption process, while oral and other routes have varying rates.
- IV > IM > Oral are the fastest to slowest routes of administration.
- IV is the only route that is IMMEDIATE (no prior process), while other routes are MEDIATE, requiring traversal of skin or mucous membranes.
- Topical administration’s systemic absorption depends on drug lipophility.
- Bioavailability refers to the amount of a drug that enters the bloodstream in its active form.
- Bioavailability for IV is 100%, while other routes have lower bioavailability.
- The absolute bioavailability compares the bioavailability of non-IV routes to IV administration.
- AUC is a measure of the total amount of drug in plasma after IV or extravascular administration. It is used to determine drug bioavailability.
- IV administration has a bioavailability of 1, while other routes have lower bioavailability.
- Bioavailability is influenced by various factors, including age, sex, genetic predisposition, and the presence of diseases.
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Description
This quiz covers the essentials of pharmacokinetics, including drug absorption, distribution, metabolism, and excretion. Learn how factors like dosage form and concentration affect the pharmacokinetic processes in the body. Test your knowledge on how drugs interact within biological systems.
