Podcast
Questions and Answers
How does liver dysfunction impact drug pharmacokinetics?
How does liver dysfunction impact drug pharmacokinetics?
- Increases blood/plasma clearance
- Reduces the extent of drug absorption
- Decreases plasma protein binding
- Affects presystemic elimination of high extraction drugs (correct)
In advanced liver cirrhosis, what effect can portal-systemic shunting have on drug pharmacokinetics?
In advanced liver cirrhosis, what effect can portal-systemic shunting have on drug pharmacokinetics?
- Enhances drug metabolism
- Decreases CYP450 enzyme activity
- Reduces presystemic elimination of high extraction drugs (correct)
- Increases plasma protein binding
How are drug-metabolizing activities affected in chronic liver diseases?
How are drug-metabolizing activities affected in chronic liver diseases?
- Uniform increase in all CYP450 enzyme activities
- Enhancement of all drug metabolism processes
- Improved presystemic elimination
- Greater reduction in glucuronidation than in CYP450 metabolism (correct)
Why is it important to consider hepatic dysfunction when adjusting drug dosages?
Why is it important to consider hepatic dysfunction when adjusting drug dosages?
What is the main purpose of the recommendations from the FDA and EMEA discussed in the text?
What is the main purpose of the recommendations from the FDA and EMEA discussed in the text?
Why is further research needed, according to the text?
Why is further research needed, according to the text?
Which parameter is highlighted as not only the most important biotransformation site but also crucial for drug pharmacokinetics?
Which parameter is highlighted as not only the most important biotransformation site but also crucial for drug pharmacokinetics?
What does the text suggest as a key area for future development in drug dosage adjustment?
What does the text suggest as a key area for future development in drug dosage adjustment?
Why is it necessary to adjust drug dosages in patients with advanced cirrhosis?
Why is it necessary to adjust drug dosages in patients with advanced cirrhosis?
What is a limitation of the Child-Pugh score in adjusting drug dosages for patients with liver dysfunction?
What is a limitation of the Child-Pugh score in adjusting drug dosages for patients with liver dysfunction?
Which statement is true regarding liver tests to predict drug elimination capacity in cirrhotic patients?
Which statement is true regarding liver tests to predict drug elimination capacity in cirrhotic patients?
Why are cirrhotic patients more sensitive to the adverse effects of certain drugs?
Why are cirrhotic patients more sensitive to the adverse effects of certain drugs?
