Pharmacokinetics and Pharmacodynamics of Peptide and Protein Drugs
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Questions and Answers

Which process is primarily responsible for the breakdown of proteins?

  • Glycolysis
  • Osmosis
  • Proteolysis (correct)
  • Photosynthesis

What is the primary organ responsible for the catabolism of small proteins?

  • Pancreas
  • Kidney (correct)
  • Liver
  • Heart

Proteins must generally be smaller than which molecular weight to undergo glomerular filtration?

  • 69 kDa (correct)
  • 150 kDa
  • 50 kDa
  • 100 kDa

What concentration comparison is made between lymph and blood for certain proteins?

<p>Lymph concentrations may be higher (C)</p> Signup and view all the answers

Why might targeting the lymphatics be beneficial for certain proteins?

<p>They act on the immune system (D)</p> Signup and view all the answers

Which pathways are utilized for the metabolism of peptide and protein drugs?

<p>Catabolic pathways (D)</p> Signup and view all the answers

What is the molecular weight threshold for proteins that undergo the most efficient glomerular filtration?

<p>30 kDa (C)</p> Signup and view all the answers

What is the fate of proteins after proteolysis?

<p>Broken down into amino acids (C)</p> Signup and view all the answers

Why are proteolytic enzymes significant in the context of protein catabolism?

<p>They are widespread throughout the body and nature (C)</p> Signup and view all the answers

What size must proteins be to have the most effective renal excretion?

<p>Smaller than 30 kDa (C)</p> Signup and view all the answers

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