Pharmacokinetics and Pharmacodynamics of Antibacterial Drugs
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Questions and Answers

What is the definition of pharmacodynamics of antibacterial drugs?

  • The study of drug absorption, distribution, metabolism, and excretion
  • The factors affecting the effectiveness of antibacterial drugs
  • The relationship between drug concentration and its antimicrobial effect (correct)
  • The principle and parameters of antibacterial drugs

    • Why is knowledge of a drug's antimicrobial pharmacodynamic effects important?

  • To understand the time course of drug absorption, distribution, metabolism, and excretion
  • To determine the dosing interval based on minimal inhibitory concentrations (MICs)
  • To define the pharmacokinetics of antibacterial drugs
  • To provide a rational basis for determination of optimal dosing regimens (correct)

    • What does pharmacokinetics refer to?

  • The principle and parameters of antibacterial drugs
  • The relationship between drug concentration and its antimicrobial effect
  • The study of the time course of drug absorption, distribution, metabolism, and excretion (correct)
  • The factors affecting the effectiveness of antibacterial drugs

    • What is the primary focus of pharmacodynamics of antibacterial drugs?

    <p>Antimicrobial effect in relation to drug concentration</p> Signup and view all the answers

    Which aspect provides a more rational basis for determination of optimal dosing regimens for antibacterial drugs?

    <p>Rate and extent of bactericidal action and post antibiotic effect</p> Signup and view all the answers

    What does the pharmacodynamics of an antimicrobial drug entail?

    <p>Understanding the concentration of an antibiotic and its ability to inhibit the growth of micro-organisms</p> Signup and view all the answers

    What is the main principle pharmacodynamic parameter used to assess the antimicrobial activity of drugs?

    <p>Minimal Inhibitory Concentrations (MIC)</p> Signup and view all the answers

    What must the antibiotic concentration at the site of infection exceed in order to obtain an antimicrobial effect?

    <p>Minimal Inhibitory Concentrations (MIC)</p> Signup and view all the answers

    What describes the minimal concentration of antibiotic that prevents a clear suspension of 105 colony-forming units (CFUs) of bacteria/mL from becoming turbid?

    <p>Minimal Inhibitory Concentrations (MIC)</p> Signup and view all the answers

    What is responsible for therapeutic success in the relationship between pharmacodynamics and pharmacokinetics of antimicrobial drugs?

    <p>MIC of the target organisms for a drug</p> Signup and view all the answers

    Which parameter is used to assess the in vitro antimicrobial activity of drugs, usually determined by finding the MIC and MBC?

    <p>Minimal Inhibitory Concentrations (MIC)</p> Signup and view all the answers

    What is necessary for bacteriostatic drugs to clear tissues of infecting microorganisms?

    <p>Host defences</p> Signup and view all the answers

    Which type of antibacterial drugs primarily require host defences to clear tissues of infecting microorganisms?

    <p>Bacteriostatic drugs</p> Signup and view all the answers

    What describes when antibacterial action continues for a period after antibiotic level falls below its MIC?

    <p>Prolonged persistent effects (post-antibiotic effect)</p> Signup and view all the answers

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