Pharmacognosy Course Overview
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Questions and Answers

Drugs are classified into ranks based on the color of their constituents.

False (B)

The pharmacological activity of crude drugs heavily relies on their chemical constituents.

True (A)

Cinchona is an example of a drug that contains both alkaloids and glycosides.

True (A)

Chemotaxonomy involves the use of chemical facts to determine the taxonomical status of animals.

<p>False (B)</p> Signup and view all the answers

Glycosides are solely found in the families of plants known for their alkaloids.

<p>False (B)</p> Signup and view all the answers

Cultivating crude drugs offers more control over quality and supply than wild drugs.

<p>True (A)</p> Signup and view all the answers

Alkaloids are commonly associated with the Solanaceae family of plants.

<p>False (B)</p> Signup and view all the answers

Tannins can be found in plants like Amla and Ashoka bark.

<p>True (A)</p> Signup and view all the answers

The family Labiatae is known to be free from alkaloids.

<p>True (A)</p> Signup and view all the answers

Ergotamine is an example of an alkaloid derived from Lycopodium spores.

<p>False (B)</p> Signup and view all the answers

Plants require only carbon dioxide and sunlight for vegetative growth.

<p>False (B)</p> Signup and view all the answers

Alkaloids in plants primarily serve as energy sources during carbon dioxide assimilation.

<p>True (A)</p> Signup and view all the answers

Mayer's reagent produces a yellow precipitate when it reacts with alkaloids.

<p>False (B)</p> Signup and view all the answers

Nitrogen, phosphorus, and potassium are classified as secondary nutrients for plants.

<p>False (B)</p> Signup and view all the answers

Auxins are synthetic plant growth regulators that promote elongation of certain plant tissues.

<p>False (B)</p> Signup and view all the answers

Catharanthus is known to contain alkaloids in all of its parts.

<p>True (A)</p> Signup and view all the answers

Ethylene is a plant growth regulator that is a gas and is involved in the ripening of fruits.

<p>True (A)</p> Signup and view all the answers

Plant growth regulators can only be found in the form of synthetic compounds.

<p>False (B)</p> Signup and view all the answers

The proper time of collection for medicinal plants is not necessary for obtaining good quality drugs.

<p>False (B)</p> Signup and view all the answers

Gibberellins are obtained from the fungus Gibberella fujikuroi and promote stem growth.

<p>True (A)</p> Signup and view all the answers

Fruits should be collected when they are unripe for optimal drug content.

<p>False (B)</p> Signup and view all the answers

Rhubarb contains anthraquinone during winter months.

<p>False (B)</p> Signup and view all the answers

Digitalis has the highest active constituents at noon.

<p>False (B)</p> Signup and view all the answers

Abscisic Acid (ABA) is a natural plant growth promoter that accelerates the aging process of plants.

<p>False (B)</p> Signup and view all the answers

Leaves are typically collected at the flowering stage.

<p>True (A)</p> Signup and view all the answers

The drying process of crude drugs is primarily used to increase their water content.

<p>False (B)</p> Signup and view all the answers

Bark is collected during the autumn season.

<p>False (B)</p> Signup and view all the answers

Roots and rhizomes have a higher water content compared to seeds.

<p>True (A)</p> Signup and view all the answers

Conium fruits contain coniin only when they are unripe.

<p>False (B)</p> Signup and view all the answers

The presence of alkaloids can be indicated by physiological actions on humans and other animals.

<p>True (A)</p> Signup and view all the answers

Pseudo tannins are recognized for their high molecular weight and positive Goldbeaters skin test result.

<p>False (B)</p> Signup and view all the answers

Alkaloids are primarily derived from carbohydrates in plant sources.

<p>False (B)</p> Signup and view all the answers

True tannins can be identified using the Goldbeaters skin test, which gives a positive reaction.

<p>True (A)</p> Signup and view all the answers

All alkaloids contain nitrogen in a heterocyclic ring structure.

<p>False (B)</p> Signup and view all the answers

Dicots have a higher concentration of alkaloids compared to Monocots.

<p>True (A)</p> Signup and view all the answers

The Vanillin test results in a pink or red color when vanillin hydrochloride is added to a tannin solution.

<p>True (A)</p> Signup and view all the answers

Caffeine is classified as a true alkaloid because it is derived from amino acids.

<p>False (B)</p> Signup and view all the answers

Natural drying methods utilize artificial heat sources to remove moisture from materials.

<p>False (B)</p> Signup and view all the answers

The lyophilization process is effective for drying heat-sensitive substances without causing thermal degradation.

<p>True (A)</p> Signup and view all the answers

Crude drugs should be stored in moist conditions to prevent deterioration.

<p>False (B)</p> Signup and view all the answers

Chemical drying with desiccators leaves a completely dried drug that can absorb 12-15% of moisture when exposed to air.

<p>False (B)</p> Signup and view all the answers

Tinctures are made by extracting crude drugs with 5-10 parts of water only.

<p>False (B)</p> Signup and view all the answers

Heat, light, and moisture are biologically related factors causing deterioration in drugs.

<p>False (B)</p> Signup and view all the answers

Ethyl alcohol is considered an ideal solvent for preparing extracts due to its volatility and selectivity.

<p>True (A)</p> Signup and view all the answers

The choice of solvent for extracting active compounds should ensure no reaction occurs with other compounds in the plant material.

<p>True (A)</p> Signup and view all the answers

Flashcards

Chemical Classification of Crude Drugs

A method of grouping crude drugs based on the chemical nature of their key components. Crucial for understanding their activity and usefulness.

Chemotaxonomical Classification

Grouping plants based on shared chemical compounds. This demonstrates relationships between plants at a deeper level than traditional classification.

Cardiotonic Drugs

Drugs that improve the contraction of the heart muscle. Examples include digitalis, squill, and strophanthus.

Carbohydrates (in crude drugs)

A group of chemical compounds found in various crude drugs, involved in various functionalities. Examples: Acacia, Tragacanth

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Glycosides (in crude drugs)

Chemical compounds in some plant-based drugs, often linked to their medicinal properties. Examples: Digitalis, Strophanthus

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Cultivating Crude Drugs

Growing herbs or plants specifically to produce crude drugs for uniformity and control.

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Wild Drug Collection

Gathering crude drugs from natural environments. Might not be as consistent in quality.

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Chemotaxonomic Marker

A specific chemical compound used to identify and classify a group of plants based on chemical similarities.

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Time of Year Effect

The chemical composition of a plant can vary significantly depending on the season.

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Time of Day Effect

The amount of active substances in some plants can fluctuate during the day, reaching peak levels at certain times.

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Maturity & Age Effect

The medicinal properties of plants can change based on their stage of growth and age.

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When to Collect Roots & Rhizomes

Roots and rhizomes are best harvested at the end of the plant's growing season, typically in autumn.

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When to Collect Bark

Bark is usually collected in the spring, when the plant is actively growing.

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When to Collect Leaves & Herbs

Leaves and herbs are best collected during the flowering stage of the plant.

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Drying Purpose

Drying plant material is important for preservation, stabilizing active constituents, preventing microbial growth, and making it easier to grind.

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Why Drying Is Important

Drying removes excess water, which can cause degradation of active constituents and promote microbial growth.

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Plant Growth Regulators

Organic compounds that influence plant growth and development in tiny amounts.

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Auxins

Plant hormones that promote stem elongation, leaf growth, and fruit development.

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Gibberellins

Plant hormones that stimulate stem elongation through cell division and cell elongation.

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Cytokinins

Plant hormones that encourage cell division and delay leaf aging.

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Ethylene

A volatile gas that promotes fruit ripening, flower wilting, and leaf shedding.

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Abscisic Acid (ABA)

A natural plant growth inhibitor that plays a role in stress responses and dormancy.

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Medicinal Plant Collection Time

The specific time of year to harvest medicinal plants to ensure the highest quality and potency of active ingredients.

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Active Constituents (Medicinal Plants)

The chemical components in medicinal plants responsible for their biological effects.

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Natural Drying

Using the sun or air to dry plant material, a slow but energy-efficient method.

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Artificial Drying

Rapid drying of plant material using controlled heat, often used in humid climates.

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Lyophilization (Freeze Drying)

Freezing plant material and removing water vapor in a vacuum, ideal for heat-sensitive substances.

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Storage of Crude Drugs

Keeping dried plant material in closed containers to prevent moisture absorption and deterioration.

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Physicochemical Deterioration

Damage to plant material caused by factors like moisture, heat, air, and light.

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Biological Deterioration

Damage to plant material caused by living organisms like fungi, bacteria, insects, and rodents.

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Ideal Extract Solvent

A solvent that selectively extracts the desired compound without reacting with it or harming humans and the environment.

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Alkaloid-Free Families

Plant families like Rosaceae and Labiatae that don't contain alkaloids, a group of nitrogen-containing compounds often found in plants.

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Ergot Alkaloids

A class of alkaloids found in the Ergot fungus, known for their impact on the circulatory and nervous systems. Ergotamine and ergometrine are examples.

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Alkaloid Distribution in Plants

Alkaloids aren't equally distributed in plants, with different parts containing different concentrations. Examples: Catharanthus (whole plant), Cinchona (bark), Nux vomica (seeds).

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Alkaloids as Plant Protection

Alkaloids act as a natural defense system, protecting plants against herbivores and insects due to their bitterness and toxicity.

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Qualitative Test for Alkaloids

Chemical tests like Dragendorff's, Mayer's, Wagner's, and Hager's reagents can identify alkaloids by forming precipitates with specific colors.

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True Tannins

Tannins with a high molecular weight, reacting positively with the Goldbeaters' skin test. They are divided into two main categories: hydrolysable and condensed.

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Pseudo Tannins

Tannins with a lower molecular weight, reacting negatively in the Goldbeaters' skin test. They don't have the same strong binding power as true tannins.

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Goldbeaters' Skin Test

A test used to identify true tannins. A small piece of skin is soaked in tannins, then treated with FeSO4. A brown or black color indicates the presence of true tannins.

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Alkaloids

Organic compounds found in plants, usually containing nitrogen in a ring structure, often with significant physiological effects on humans and animals.

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True Alkaloids

Alkaloids with a nitrogen atom in a heterocyclic ring and derived from amino acids. E.g., Quinine, Colchicine.

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Pseudo Alkaloids

Alkaloids with a nitrogen atom in a heterocyclic ring, but not derived from amino acids. E.g., Caffeine.

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Study Notes

Pharmacognosy Course Information

  • Course name: Pharmacognosy
  • Department: Pharmacy
  • Instructor: Dr. Essam Ali Hassan Faraj
  • Semester: Fall 2024-2025
  • Number of pages: 23

Definition of Pharmacognosy

  • Pharmacognosy is derived from Greek words "Pharmakon" meaning drug or medicine, and "gignosco" meaning to acquire knowledge.
  • It is the study of drugs derived from natural sources (plants, animals, microorganisms, minerals).
  • It investigates the physical, chemical, biochemical, and biological properties of natural drugs.
  • It also includes the search for new drugs from natural sources.
  • It does not include the study of synthetic drugs.
  • It relates to Botany, Ethnobotany, Marine Biology, Herbal Medicine, Chemistry (Phytochemistry), Pharmacology, and Pharmaceutics.

Crude Drugs

  • Crude drugs typically come from plants, animals, or minerals, in raw form.
  • They are used for treating various ailments.
  • Important natural sources include higher plants, microbes, animals, and marine organisms, and some minerals that are organic and inorganic in nature.
  • Crude drug classifications include alphabetical, taxonomical, morphological, pharmacological, chemical, and chemotaxonomical.

Crude Drug Classification Methods

  • Alphabetical: Arranging drugs alphabetically based on their Latin and common names.

  • Advantages: Easy to use and quick; no repeated entries.

  • Disadvantages: Does not specify drug origin (plant, animal, mineral).

  • Taxonomical: Organizing drugs based on their plant classification (division, class, family, genus, and species).

  • Advantages: Helpful for understanding evolutionary developments.

  • Disadvantages: Does not correlate chemical constituents with biological activity.

  • Morphological: Grouping drugs according to the parts used (leaves, stems, roots, etc.).

  • Advantages: Useful for identification, detecting adulteration, and practical study of drugs when their chemical structure is unknown.

  • Organized drugs (have structure; like leaves, flowers)

  • Unorganized drugs (e.g., juices, latex, or resins)

  • Pharmacological: Sorting drugs based on their pharmacological action or therapeutic use.

  • Advantages: More relevant and commonly used method because drugs with similar actions are grouped together.

  • Chemical: Grouping drugs according to the chemical nature of their principal constituent.

  • Advantages: Useful for suggesting substitutes and better understanding of therapeutic significance based on the chemical constitution.

  • Disadvantages: Difficult to categorize when drugs have multiple chemical compounds.

  • Chemotaxonomical: This method classifies plants based on the chemical similarities in their constituents to understand relationships and evolution within a plant group.

  • For instance, some alkaloids (e.g., tropane alkaloids) are found in certain groups (e.g., Solanaceae family plants), which can be used as characteristic markers.

Drug Cultivation, Collection, and Drying

  • Cultivation Advantages: Uniform quality, improved collection, transport, access to processing, better soil quality/pest/disease management, and controlled supply.

  • Factors Affecting Cultivation: Altitude, temperature, rainfall/humidity, soil/fertility, fertilizers, and pests/pest control.

  • Plant material is dried: to prevent deterioration via chemical or biological means.

  • Methods of drying: Natural drying (using sunlight or shade), artificial drying (using ovens, heated stones, or direct fire) or Lyophilization (freeze-drying).

  • Storage of Crude Drugs: Store in closed containers in a dry environment to avoid unwanted changes and moisture.

Pharmacognostic Evaluation of Medicinal Plants and Preparation of Crude Drugs

  • Extracts are preparations of crude drugs containing all soluble constituents.
  • Tinctures are solutions obtained by extraction of crude drugs with alcohol..
  • The extraction solvent must be selective for the compound of interest, cost-effective, non-reactive with other compounds, and non-harmful to the environment. Ethanol is commonly used for extraction of active compounds.

Methods of Extraction

  • Several methods exist for extraction of active compounds from plant materials. Techniques include infusion, maceration, percolation, digestion, and decoction.

Cell Content and Plant Constituents

Different crude plants can contain components with different functions, such as:

  • Volatile oils: Naturally-occurring aromatic components with odors are contained in certain tissues of some plants.
  • Tannins: Complex organic compounds derived from polyhydric benzoic acids (present in leaves, barks, and fruits) and have various properties.
  • Alkaloids: Nitrogen-containing compounds with basic properties derived from amino acids found in certain plants having effects on humans.

Other important concepts

  • Time of the year: The time of year for collection can affect the amount or type of active compounds.
  • Time of day: Some drugs have different levels of active compounds at different times of the day.
  • Stages of maturity: The maturity stage of the plant can impact the properties of the crude drug.
  • Qualitative tests for Alkaloids: Various reagents (e.g., Dragendorff's reagent) may reveal alkaloids' presence.

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Description

This quiz covers essential aspects of Pharmacognosy, including definitions, the study of natural drugs, and the importance of crude drugs derived from various sources. It also highlights the interconnected fields such as Botany and Pharmacology. Test your understanding of these foundational concepts in this Pharmacognosy course.

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