Introduction to Pharmacognosy

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Questions and Answers

What does pharmacognosy primarily study?

  • Biological, biochemical, and therapeutic features of crude drugs (correct)
  • Pharmaceutical marketing strategies
  • Chemical engineering processes in drug manufacturing
  • The use of synthetic drugs in modern medicine

Who coined the term 'pharmacognosy' and in what year?

  • Carl Wilhelm Scheele in 1780
  • C.A. Seydler in 1815 (correct)
  • Alexander Fleming in 1928
  • Hippocrates in 400 BC

Which Greek terms is 'pharmacognosy' derived from?

  • Pharmacy and therapy
  • Pharmakon and gnosis (correct)
  • Pharmacology and synthesis
  • Pharmaceutical and knowledge

What is NOT included in the scope of pharmacognosy?

<p>Analysis of synthetic drugs (D)</p> Signup and view all the answers

What has been the historical basis for the use of plant materials in medicine?

<p>Intuition and random selection of plants by early humans (C)</p> Signup and view all the answers

Which of the following historical regions is mentioned as having utilized plants for medicinal purposes?

<p>China, India, Egypt, and Greece (B)</p> Signup and view all the answers

Which of the following is NOT a focus area of pharmacognosy?

<p>Manufacturing of vaccines from animal sources (D)</p> Signup and view all the answers

Why might pharmacognosy be considered an ancient practice?

<p>It has roots tracing back to prehistoric uses of plants (A)</p> Signup and view all the answers

Who was the author of the significant work 'Botanist with Hontry Trime' that influenced pharmacognosy?

<p>Robert Bently (C)</p> Signup and view all the answers

Which plant was identified for its active principle morphine?

<p>Papaver somniferum (B)</p> Signup and view all the answers

What was the first medicinal application of morphine?

<p>Analgesic for pain relief (D)</p> Signup and view all the answers

What role does pharmacognosy play in modern medicine?

<p>It contributes to the understanding of chemical constituents of drugs. (D)</p> Signup and view all the answers

Which of the following compounds was isolated by Pelletier from cinchona?

<p>Quinine (C)</p> Signup and view all the answers

What is one area that modern pharmacognosy encompasses besides plant-derived substances?

<p>Synthetic substitutes (C)</p> Signup and view all the answers

What does the scope of pharmacognosy include?

<p>Crude drugs from various sources (C)</p> Signup and view all the answers

Which science is NOT mentioned as being integral to the growth of modern pharmacognosy?

<p>Physics (A)</p> Signup and view all the answers

What is a primary reason for the preparation of crude drugs before marketing?

<p>To stabilize them in transport and storage (B)</p> Signup and view all the answers

Which aspect of pharmacognosy is essential for producing new plant drugs in modern medicine?

<p>Purification of phytochemicals (A)</p> Signup and view all the answers

What is a potential drawback of collecting wild plants for crude drug preparation?

<p>Labor-intensive and unscientific methods (B)</p> Signup and view all the answers

Which method is NOT typically used in the processing of crude drugs?

<p>Chemical synthesis (A)</p> Signup and view all the answers

Pharmacognosy serves as a link between which two medical approaches?

<p>Ayurveda and Allopathic systems (A)</p> Signup and view all the answers

What is meant by 'garbling' in the preparation of crude drugs?

<p>The removal of impurities and foreign matter (C)</p> Signup and view all the answers

Why is knowledge of pharmacology important in pharmacognosy?

<p>To understand the action of drugs in health care (D)</p> Signup and view all the answers

What is the aim of collecting crude drugs from plant materials?

<p>To ensure maximum active constituents are collected (D)</p> Signup and view all the answers

What happens to colophony when it is stored in powdered form?

<p>It gets oxidized. (D)</p> Signup and view all the answers

Which method is used for extracting active principles that are not soluble in cold or boiling water?

<p>Decoction (D)</p> Signup and view all the answers

What is the purpose of replacing air with an inert gas like nitrogen for certain drugs?

<p>To prevent destruction from atmospheric oxygen. (A)</p> Signup and view all the answers

Why should drugs be stored in air-tight containers?

<p>To prevent oxidation from air exposure. (B)</p> Signup and view all the answers

How can lard be preserved to protect it from rancidity?

<p>By adding siam benzoin. (B)</p> Signup and view all the answers

Which of the following is not a method of preparing herbal dosage forms?

<p>Fermentation (C)</p> Signup and view all the answers

What temperature conditions are recommended for storing costly phytopharmaceuticals?

<p>At refrigerated temperature in closed containers. (D)</p> Signup and view all the answers

Which part of the plant is commonly used in the decoction method?

<p>Woody parts like roots and barks. (C)</p> Signup and view all the answers

When should underground parts, such as roots and bulbs, be collected?

<p>At the end of flowering and fruiting (C)</p> Signup and view all the answers

Why should fruits and flowers be collected only after maturity?

<p>Mature parts provide better pharmaceutical value (A)</p> Signup and view all the answers

What is the primary purpose of drying harvested drugs?

<p>To remove moisture and resist microbial growth (A)</p> Signup and view all the answers

Which harvesting method is recommended for leaves and fruits?

<p>Hand-picking by skilled workers (C)</p> Signup and view all the answers

When is the best time to collect barks from trees?

<p>In spring or early summer when cambium is active (D)</p> Signup and view all the answers

Which statement is true about the collection of sap?

<p>Sap is collected in spring as it rises (C)</p> Signup and view all the answers

What significant pharmacological text was written by Emperor Shen Nung?

<p>Pen-t-Sao (A)</p> Signup and view all the answers

Who is recognized as the first pharmacist in history?

<p>Galen (D)</p> Signup and view all the answers

Which method is used to collect specific parts of flowers like petals or whole flowers?

<p>Selective hand-picking (D)</p> Signup and view all the answers

Which of the following systems of medicine is primarily based in India?

<p>Ayurveda (C)</p> Signup and view all the answers

What should be avoided when collecting underground parts during summer?

<p>Impact on survival and regeneration in the following season (D)</p> Signup and view all the answers

What was the practice that introduced the idea of using plants based on their physical characteristics?

<p>Doctrine of Signatures (B)</p> Signup and view all the answers

Which of the following describes a consequence of the increasing trade in crude drugs from the 12th century?

<p>Heightened fraudulent practices in drug trade (D)</p> Signup and view all the answers

What were the main methods of communication used to share medicinal plant knowledge before written records?

<p>Word of mouth and carvings (C)</p> Signup and view all the answers

What is the term that was used in the 19th century to describe the subject now known as pharmacognosy?

<p>Materia Medica (A)</p> Signup and view all the answers

Which ancient texts are well-known treatises in the field of Ayurveda?

<p>Sushruta Samhita and Charaka Samhita (C)</p> Signup and view all the answers

Flashcards

Pharmacognosy Definition

The study of plants, animals, and minerals used as medicine, including their biological, chemical, and therapeutic properties. It covers the history, distribution, collection, processing, and preservation of these natural sources.

Pharmacognosy Origin

The use of plants for medicine dates back to ancient times, with early humans likely discovering medicinal properties through trial and error.

Crude Drugs

Raw materials from plants, animals, or minerals used in traditional medicine

Pharmacognosy Roots

Pharmacognosy traces its history back to the earliest uses of natural substances for healing, long before modern medicine.

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Ancient Medicine

The use of plants as medicine by early civilizations in places like China, India, Egypt, and Greece.

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Plant Kingdom Importance

Provides the raw materials for medicines, food, clothing, and shelter, and serves as a storehouse of useful remedies.

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Crude Extracts

Medicinal substances extracted from plants and other sources in their raw form, without any processing.

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Materia Medica

The study of medicinal materials, originally referring to plants, animals, and minerals used for healing.

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Doctrine of Signatures

A medieval belief that the shape or appearance of a plant indicates its medicinal use for a particular ailment, its 'signature'.

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Pharmacognosy

The study of natural drug sources, including their chemical composition, biological properties, historical uses, and modern applications.

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Adulteration

The act of replacing a valuable ingredient with a cheaper or ineffective substitute, often in crude drugs.

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Ayurveda

An ancient Indian system of medicine combining lifestyle, diet, herbal remedies, and more for holistic health.

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Pen-t-Sao

An ancient Chinese book of herbal remedies, containing entries for specific drugs based on the days of the year.

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Charaka Samhita and Sushruta Samhita

Ancient Ayurvedic medical textbooks outlining the theoretical and practical aspects of healthcare.

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Pharmacognosy

A branch of science that studies drugs derived from natural sources (plants, animals, and minerals), and other substances used in medicine, like synthetic sutures.

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Medicinal plants

Plants used to treat illness or injuries.

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Active principles

The specific components of a drug that produce the therapeutic effect.

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Isolation of active principles

The process of separating and identifying the active components from natural substances, like plants.

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Pharmacopoeia

An official list of drugs and their standards for quality, purity, and strength.

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Morphine

An active principle isolated from opium poppy, used as a medicine.

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Quinine

An active principle isolated from Cinchona bark, used to treat malaria.

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Semi-synthetic derivatives

Modified forms of naturally occurring drugs, improved for effectiveness or safety.

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Synthetic substitutes

Artificially created drug molecules having similar effects to naturally occurring drugs.

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Crude drugs

Unprocessed natural products used as medicines, coming from plants, animals, or minerals.

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Modern Pharmacognosy

The study of natural medicines that now utilizes methods from related disciplines like chemistry, biochemistry, and pharmacology to further our understanding of medicinal plants and other sources.

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Pharmacognosy's Role

Pharmacognosy links pharmacology and medicinal chemistry, using phytochemicals instead of traditional preparations to produce new plant-based medications, understanding drug effects on living systems, and acting as a crucial base for developing new medicines.

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Crude Drugs Utility

Crude drugs are raw materials used to make medicines, often as sources or intermediates for synthesizing active compounds.

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Crude Drug Preparation

Preparing crude drugs involves steps like stabilizing them, removing impurities, and tailoring them for pharmaceutical standardization.

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Collection of Wild Plants

Collection of wild plants for medicine is often unscientific, high-labor, and unreliable, leading to risks of misidentification and poisonous materials.

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Plant Collection Process

Collecting medicinal plants begins when collectors are available and there is market demand; plants are harvested to maximize active ingredient concentration.

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Underground Part Collection Time

Collect roots, corms, bulbs, rhizomes, and tubers during July-August and March-April, the end of flowering and fruiting periods.

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Underground Part Preparation

Clean and dry collected underground parts in shade or ovens at 30°C to maintain their properties and prevent spoilage.

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Summer Underground Part Collection

Collecting underground parts in summer negatively impacts their survival and regeneration in the next growing season.

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Fruit/Flower Collection

Collect individual fruits and flowers only after maturity.

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Annual Stem Collection

Cut annual stems 5-10cm above ground after flowering.

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Leaf Collection Stage

Collect leaves in their young stage when chemical constituents are higher.

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Flower Part Collection

Collect specific parts of flowers like petals, whole flowers, or flower buds separately, depending on the use.

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Fruit/Berry Harvest Time

Collect fruits and berries in early autumn.

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Bark Collection Time

Collect bark in spring or early summer when cambium is active for easier detachment.

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Sap Collection Time

Collect sap in spring as it rises.

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Latex Collection Method

Squeeze stems over a bowl using gloves to collect milky latex.

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Harvesting Skill

Skilled workers ensure proper and selective collection of crude drugs, maximizing quality.

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Harvesting Tools

Use hand-picking for leaves and fruits while mechanical devices like diggers, lifters, binders, strippers, mowers, or reapers are for other plant parts.

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Drying Purpose

Drying removes moisture, preserves the quality, and makes grinding easier for crude drugs.

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Drug Sunlight Degradation

Direct sunlight exposure breaks down the active chemical compounds in drugs.

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Drug Shape Preservation

Drug shape affects how well it is preserved. Whole drugs last longer than powdered ones.

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Colophony Powder Oxidation

Colophony, when powdered, oxidizes faster, reducing its quality.

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Ergot Defatting

To prevent rancidity, ergot is treated with a lipid solvent before storage.

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Lard Rancidity Prevention

Adding Siam benzoin to lard preserves it from becoming rancid.

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Airtight Container Storage

Drugs need airtight containers to avoid oxidation from atmospheric oxygen.

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Inert Gas Storage

Drugs like shark-liver oil are stored with inert gases to prevent oxygen damage.

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Insect & Hydrocyanic Protection

Drugs need protection against insects and hydrocyanic acid during storage.

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Low Temperature Storage

High temperatures cause drug degradation, requiring low-temperature storage.

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Phytopharmaceutical Preservation

Expensive plant-based drugs are preserved at cool temperatures in closed containers.

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Crude Drug Processing

Treating and modifying medicinal plants to utilize their active components.

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Active Principles Action

Active ingredients of plants can have specific effects on body organs.

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Herb Extraction Methods

Various processes are used to extract medicinal substances from plants.

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Decoction Method

Herbal preparation method where the plant material is boiled in water.

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Maceration Method

A process of extracting active chemicals from plant materials with cold water.

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Infusion Method

Herbal preparation method where plant material steeped in hot water.

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Juice Extraction

Method for getting herbal juice from plants.

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Study Notes

Introduction to Pharmacognosy

  • Pharmacognosy is a branch of bioscience studying the biological, biochemical, and therapeutic properties of crude drugs from plants, animals, and minerals.
  • It's a scientific study of crude drugs from natural sources, including their history, distribution, cultivation, collection, processing, and preservation.
  • It also involves studying physical, chemical, and structural characters of crude drugs, as well as other materials used in pharmacy (e.g., suspending agents, flavoring agents, antibiotics, allergens).

History of Pharmacognosy

  • The origins of pharmacognosy are ancient, with plants being used in medicine long before recorded history.
  • Ancient civilizations like Chinese, Indian, Egyptian, and Greek used plants medicinally for thousands of years.
  • Key figures in pharmacognosy's development include Emperor Shen Nung in 3000 BCE, with his work Pen-t-Sao.
  • The term "pharmacognosy" was coined by C.A. Seydler in 1815.
  • The Greek words "pharmacon" (drug) and "gnosis" (knowledge) combine to form the term.

Reason for Studying Pharmacognosy

  • Crude drugs have been used for medicinal purposes whether rationally or not.
  • The 12th century saw an increase in trade of crude drugs.
  • This led to the importance of studying crude drugs for more accurate and effective use.
  • Adulteration of drugs, such as opium with Lactuca gum or latex, highlights the need for accurate identification and description of plants and drugs.
  • Important works in this area include the volumes of medicinal plants written by Robert Bentley.

Scope and Importance of Pharmacognosy

  • Pharmacognosy encompasses the study of crude drugs from plants, animals, and minerals, as well as supplementary substances used in medical practice.
  • It plays a crucial role in the development of various fields of science.
  • Modern pharmacognosy combines chemical analysis with the knowledge of traditional use.
  • This leads to the development of new drugs and remedies.
  • It is connected with the origin of new medicines and remedies.
  • It forms a link between pharmacology medicine and chemistry.

Collection and Processing of Crude Drugs

  • Crude drugs need preparation for marketing, including stabilizing them, removing impurities, and ensuring pharmaceutical value.
  • Methods include collection, drying, and garbling.
  • Different parts of plants (roots, leaves, fruits, barks) are collected at various stages to maximize active compounds.
  • Plants are often harvested at specific times to ensure optimal amounts of active constituents.
  • Drying methods include natural drying, oven-drying, vacuum-drying, and spray-drying to preserve the material's quality and reduce moisture for a longer shelf life..
  • Packing should consider the drug's morphology, chemical characteristics, intended use, and transport/storage conditions

Methods of Plant Collection

  • Plant collection involves careful consideration of the environmental conditions and plant maturity stages.
  • Skilled and trained collectors are essential.
  • Different parts of plants are collected at specific times for optimal therapeutic value.
  • Mechanical and manual collection techniques are used for different parts of plants.

Methods of Preparation

  • Plants are processed in different methods to prepare different types of medicinal preparations (e.g., decoction, maceration, infusion), based on the properties of the active constituents.
  • Decoction is a boiling method for extracting compounds from materials that are not easily dissolved with cold water
  • Maceration involves soaking crude drugs in water to extract the active components.
  • Infusions use hot or cold water to steep herbal parts
  • Extraction of juice uses a similar technique to decoction to separate the active compounds.

Garbling and Packaging

  • Garbling is the removal of impurities from crude drugs to improve quality.
  • Drugs are packed according to different characteristics concerning morphological and chemical properties for safe transport.
  • Various packaging materials are used, depending on the characteristics of the crude drug, including goatskin, kerosene tins, and gunny bags.

Storage of Drugs

  • Proper storage methods need to be employed to protect the drugs from microbial decomposition, oxidation, and deterioration of the active constituents.
  • The storage environment needs to be free from moisture, sunlight, and high temperatures, to prevent degradation or structural changes.

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