Pharmacogenomics Quiz

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What is the goal of pharmacogenomics?

To identify potential aspects in research

To describe basic pharmacogenomic terms and principles

To represent variability of a specific gene

To identify polymorphisms and their impact on pharmacokinetics and/or pharmacodynamics (correct)

What is the human genome project of 2003?

A project to identify potential aspects in research

A project to develop new drugs

A project to study the human genome (correct)

A project to represent variability of a specific gene

Which term refers to the study of genetic factors that underlie variation in drug response?

Genotype

Pharmacogenetics

Pharmacogenomics (correct)

Genomics

What is the most common kind of polymorphism?

SNPs Signup and view all the answers

What is the term used to describe an individual's collection of genes?

Genotype Signup and view all the answers

Which of the following is a prodrug that must be metabolized into morphine for activity?

Codeine Signup and view all the answers

What is the function of CYP2D6 on codeine, a prodrug?

Increased function of CYP2D6 results in a proportional increase in the morphine concentration Signup and view all the answers

Which allele of TPMT is associated with decreased TPMT enzyme activity and increased toxicity risk?

TPMT*3C Signup and view all the answers

Which of the following is the study of genetic factors that underlie varying responses to drugs and medication?

Pharmacogenomics Signup and view all the answers

Which of the following characteristics should NOT be prioritized in the study of pharmacogenomics?

Wide therapeutic index Signup and view all the answers

Polymorphisms are defined as a variation in a gene, DNA sequence, or a chromosome in what percentage of the population?

<blockquote> 1% </blockquote> Signup and view all the answers

Which of the following is NOT true about the action of warfarin?

It is metabolized by CYP2C9 Signup and view all the answers

Which CYP2C9 allele results in a decrease in CYP2C9 activity by 90%?

CYP2C9*3 variant allele Signup and view all the answers

Which of the following VKORC1 haplotypes is associated with requiring a lower warfarin dose?

Group A haplotypes Signup and view all the answers

Pharmacogenomics Quiz

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Questions and Answers

What is the goal of pharmacogenomics?

What is the human genome project of 2003?

Which term refers to the study of genetic factors that underlie variation in drug response?

What is the most common kind of polymorphism?

What is the term used to describe an individual's collection of genes?

Which of the following is a prodrug that must be metabolized into morphine for activity?

What is the function of CYP2D6 on codeine, a prodrug?

Which allele of TPMT is associated with decreased TPMT enzyme activity and increased toxicity risk?

Which of the following is the study of genetic factors that underlie varying responses to drugs and medication?

Which of the following characteristics should NOT be prioritized in the study of pharmacogenomics?

Polymorphisms are defined as a variation in a gene, DNA sequence, or a chromosome in what percentage of the population?

Which of the following is NOT true about the action of warfarin?

Which CYP2C9 allele results in a decrease in CYP2C9 activity by 90%?

Which of the following VKORC1 haplotypes is associated with requiring a lower warfarin dose?

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