Podcast
Questions and Answers
What is the goal of pharmacogenomics?
What is the goal of pharmacogenomics?
- To identify potential aspects in research
- To describe basic pharmacogenomic terms and principles
- To represent variability of a specific gene
- To identify polymorphisms and their impact on pharmacokinetics and/or pharmacodynamics (correct)
What is the human genome project of 2003?
What is the human genome project of 2003?
- A project to identify potential aspects in research
- A project to develop new drugs
- A project to study the human genome (correct)
- A project to represent variability of a specific gene
Which term refers to the study of genetic factors that underlie variation in drug response?
Which term refers to the study of genetic factors that underlie variation in drug response?
- Genotype
- Pharmacogenetics
- Pharmacogenomics (correct)
- Genomics
What is the most common kind of polymorphism?
What is the most common kind of polymorphism?
What is the term used to describe an individual's collection of genes?
What is the term used to describe an individual's collection of genes?
Which of the following is a prodrug that must be metabolized into morphine for activity?
Which of the following is a prodrug that must be metabolized into morphine for activity?
What is the function of CYP2D6 on codeine, a prodrug?
What is the function of CYP2D6 on codeine, a prodrug?
Which allele of TPMT is associated with decreased TPMT enzyme activity and increased toxicity risk?
Which allele of TPMT is associated with decreased TPMT enzyme activity and increased toxicity risk?
Which of the following is the study of genetic factors that underlie varying responses to drugs and medication?
Which of the following is the study of genetic factors that underlie varying responses to drugs and medication?
Which of the following characteristics should NOT be prioritized in the study of pharmacogenomics?
Which of the following characteristics should NOT be prioritized in the study of pharmacogenomics?
Polymorphisms are defined as a variation in a gene, DNA sequence, or a chromosome in what percentage of the population?
Polymorphisms are defined as a variation in a gene, DNA sequence, or a chromosome in what percentage of the population?
Which of the following is NOT true about the action of warfarin?
Which of the following is NOT true about the action of warfarin?
Which CYP2C9 allele results in a decrease in CYP2C9 activity by 90%?
Which CYP2C9 allele results in a decrease in CYP2C9 activity by 90%?
Which of the following VKORC1 haplotypes is associated with requiring a lower warfarin dose?
Which of the following VKORC1 haplotypes is associated with requiring a lower warfarin dose?
