Pharmacogenomics Quiz
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Questions and Answers

What is the goal of pharmacogenomics?

  • To identify potential aspects in research
  • To describe basic pharmacogenomic terms and principles
  • To represent variability of a specific gene
  • To identify polymorphisms and their impact on pharmacokinetics and/or pharmacodynamics (correct)

    • What is the human genome project of 2003?

  • A project to identify potential aspects in research
  • A project to develop new drugs
  • A project to study the human genome (correct)
  • A project to represent variability of a specific gene

    • Which term refers to the study of genetic factors that underlie variation in drug response?

  • Genotype
  • Pharmacogenetics
  • Pharmacogenomics (correct)
  • Genomics

    • What is the most common kind of polymorphism?

    <p>SNPs</p> Signup and view all the answers

    What is the term used to describe an individual's collection of genes?

    <p>Genotype</p> Signup and view all the answers

    Which of the following is a prodrug that must be metabolized into morphine for activity?

    <p>Codeine</p> Signup and view all the answers

    What is the function of CYP2D6 on codeine, a prodrug?

    <p>Increased function of CYP2D6 results in a proportional increase in the morphine concentration</p> Signup and view all the answers

    Which allele of TPMT is associated with decreased TPMT enzyme activity and increased toxicity risk?

    <p>TPMT*3C</p> Signup and view all the answers

    Which of the following is the study of genetic factors that underlie varying responses to drugs and medication?

    <p>Pharmacogenomics</p> Signup and view all the answers

    Which of the following characteristics should NOT be prioritized in the study of pharmacogenomics?

    <p>Wide therapeutic index</p> Signup and view all the answers

    Polymorphisms are defined as a variation in a gene, DNA sequence, or a chromosome in what percentage of the population?

    <blockquote> <p>1%</p> </blockquote> Signup and view all the answers

    Which of the following is NOT true about the action of warfarin?

    <p>It is metabolized by CYP2C9</p> Signup and view all the answers

    Which CYP2C9 allele results in a decrease in CYP2C9 activity by 90%?

    <p>CYP2C9*3 variant allele</p> Signup and view all the answers

    Which of the following VKORC1 haplotypes is associated with requiring a lower warfarin dose?

    <p>Group A haplotypes</p> Signup and view all the answers

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