3 Questions
Which proteins are involved in drug transport?
ABC and SLC
Which genes have polymorphisms that can influence enzymatic activity?
DME-encoding genes
What is the purpose of phase IV analysis in clinical trials?
To analyze reported adverse effects with pharmacogenetic tests
Study Notes
Drug Transport and Pharmacogenetics
- P-glycoprotein (P-gp), a transmembrane protein, plays a crucial role in drug transport by pumping out xenobiotics from cells.
- Multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP) are also involved in drug transport.
- Genetic polymorphisms in genes such as CYP2D6, CYP2C9, and CYP3A5 can influence enzymatic activity, leading to variations in drug metabolism.
- Variations in the ABCB1 gene, which codes for P-gp, can affect the transport of drugs across the blood-brain barrier.
Clinical Trials
- Phase IV analysis in clinical trials involves post-marketing surveillance to detect and monitor the safety and efficacy of a drug after its approval and release to the market.
- The purpose of phase IV analysis is to identify rare or long-term adverse effects, determine the optimal dosage, and evaluate the drug's effectiveness in real-world scenarios.
Test your knowledge on candidate genes, drug transporters, and drug-metabolizing enzymes in this quiz on pharmacogenomics. Learn about the genetic variations and functional polymorphisms that influence drug transport and enzymatic activity. Explore the role of pharmacogenomics in clinical trials and drug target identification.
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