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Questions and Answers
Which proteins are involved in drug transport?
Which proteins are involved in drug transport?
- XYZ and PQR
- DEF and GHI
- ABC and SLC (correct)
- MNO and UVW
Which genes have polymorphisms that can influence enzymatic activity?
Which genes have polymorphisms that can influence enzymatic activity?
- Candidate genes
- DME-encoding genes (correct)
- Pharmacogenetic test genes
- Drug target genes
What is the purpose of phase IV analysis in clinical trials?
What is the purpose of phase IV analysis in clinical trials?
- To interpret trial results based on pharmacogenetic test results
- To analyze reported adverse effects with pharmacogenetic tests (correct)
- To identify drug targets
- To assess patient selection criteria
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Study Notes
Drug Transport and Pharmacogenetics
- P-glycoprotein (P-gp), a transmembrane protein, plays a crucial role in drug transport by pumping out xenobiotics from cells.
- Multidrug resistance-associated proteins (MRPs) and breast cancer resistance protein (BCRP) are also involved in drug transport.
- Genetic polymorphisms in genes such as CYP2D6, CYP2C9, and CYP3A5 can influence enzymatic activity, leading to variations in drug metabolism.
- Variations in the ABCB1 gene, which codes for P-gp, can affect the transport of drugs across the blood-brain barrier.
Clinical Trials
- Phase IV analysis in clinical trials involves post-marketing surveillance to detect and monitor the safety and efficacy of a drug after its approval and release to the market.
- The purpose of phase IV analysis is to identify rare or long-term adverse effects, determine the optimal dosage, and evaluate the drug's effectiveness in real-world scenarios.
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