Pharmacogenomics in Clinical Practice

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What is the significance of genomically defined targets in drug development?

They increase success rates in drug development. (correct)

They have no impact on drug development.

They are not used in drug development.

They decrease success rates in drug development.

What is the current status of pharmacogenomics in terms of implementation?

It has been fully implemented in clinical practice.

It has been abandoned due to lack of progress.

It is being explored for potential implementation in clinical practice. (correct)

It is being researched in academic settings.

What percentage of prescriptions in the USA are affected by actionable germline pharmacogenes?

25%

50% (correct)

75%

90%

What is the focus of pharmacogenomics research in academic settings over the past few decades?

Academic research Signup and view all the answers

What aspect of pharmacogenomics is expected to have an impact on future studies?

All of the above Signup and view all the answers

What is the impact of genetic variation in pharmacogenes on drug response?

It affects drug response in a significant way. Signup and view all the answers

What is the expected outcome of pharmacogenomic testing on depressive symptom remission?

Improved depressive symptom remission Signup and view all the answers

What is the primary association of CYP2C19 genotype with clopidogrel therapy?

Antiplatelet effect and clinical efficacy Signup and view all the answers

Which of the following is NOT a term related to allergic diseases?

Genophenotypes Signup and view all the answers

What is the primary outcome of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention?

Improved clinical efficacy Signup and view all the answers

What is the expected outcome of ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA?

Better outcomes with ticagrelor Signup and view all the answers

What is the primary focus of PharmVar GeneFocus?

CYP2D6 genotype Signup and view all the answers

What is the primary function of the CYP2D6 and CYP2C19 genes?

To metabolize certain medications in the body Signup and view all the answers

What is the primary focus of the Genetics of Hypertension Associated Treatment (GenHAT) study?

To investigate the genetic factors influencing hypertension Signup and view all the answers

What is the main finding of the study by Maranville and Cox?

Pharmacogenomic variants have larger effect sizes than genetic variants associated with other complex traits Signup and view all the answers

What is the primary goal of genome-wide association studies (GWAS) in pharmacogenomics?

To identify genetic variants associated with complex traits Signup and view all the answers

What is the primary focus of the study by Hawcutt et al?

To study the susceptibility to corticosteroid-induced adrenal suppression Signup and view all the answers

What is the primary finding of the meta-analysis by Koopmans et al?

The global variation in frequencies of variants in CYP2D6 and CYP2C19 is significant Signup and view all the answers

What is the title of the report written by the Royal College of Physicians and British Pharmacological Society?

Personalised prescribing: using pharmacogenomics to improve patient outcomes Signup and view all the answers

In what year was the paper 'Pharmacogenomics in the UK National Health Service: opportunities and challenges' published?

2020 Signup and view all the answers

What is the name of the model for the clinical implementation of pre-emptive pharmacogenetics?

PG4KDS Signup and view all the answers

What is the title of the paper written by van der Wouden et al.?

Implementing pharmacogenomics in Europe Signup and view all the answers

In what journal was the paper by Hoffman et al. published?

Am.J.Med.Genet.C.Semin.Med.Genet. Signup and view all the answers

What is the title of the paper by Matey et al.?

Nine-gene pharmacogenomics profile service: the Mayo Clinic experience Signup and view all the answers

What is the primary concern with DGAT1 inhibition using AZD7687?

Intolerable side effects Signup and view all the answers

What is the purpose of biobanks and electronic medical records in research?

To enable cost-effective research Signup and view all the answers

What is the association between the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene and cataract risk?

Common and rare genetic variation are both associated with cataract risk Signup and view all the answers

What is the significance of the HLA-B*55:01 allele in relation to penicillin allergy?

It increases the risk of penicillin allergy Signup and view all the answers

What is the use of genome-wide association studies in the context of drug development?

To identify genetic markers for drug-induced hypersensitivity reactions Signup and view all the answers

What is the purpose of vemurafenib in the treatment of advanced melanoma?

To treat BRAF V600-mutant advanced melanoma Signup and view all the answers