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Questions and Answers
What is the significance of genomically defined targets in drug development?
What is the significance of genomically defined targets in drug development?
- They increase success rates in drug development. (correct)
- They have no impact on drug development.
- They are not used in drug development.
- They decrease success rates in drug development.
What is the current status of pharmacogenomics in terms of implementation?
What is the current status of pharmacogenomics in terms of implementation?
- It has been fully implemented in clinical practice.
- It has been abandoned due to lack of progress.
- It is being explored for potential implementation in clinical practice. (correct)
- It is being researched in academic settings.
What percentage of prescriptions in the USA are affected by actionable germline pharmacogenes?
What percentage of prescriptions in the USA are affected by actionable germline pharmacogenes?
- 25%
- 50% (correct)
- 75%
- 90%
What is the focus of pharmacogenomics research in academic settings over the past few decades?
What is the focus of pharmacogenomics research in academic settings over the past few decades?
What aspect of pharmacogenomics is expected to have an impact on future studies?
What aspect of pharmacogenomics is expected to have an impact on future studies?
What is the impact of genetic variation in pharmacogenes on drug response?
What is the impact of genetic variation in pharmacogenes on drug response?
What is the expected outcome of pharmacogenomic testing on depressive symptom remission?
What is the expected outcome of pharmacogenomic testing on depressive symptom remission?
What is the primary association of CYP2C19 genotype with clopidogrel therapy?
What is the primary association of CYP2C19 genotype with clopidogrel therapy?
Which of the following is NOT a term related to allergic diseases?
Which of the following is NOT a term related to allergic diseases?
What is the primary outcome of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention?
What is the primary outcome of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention?
What is the expected outcome of ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA?
What is the expected outcome of ticagrelor versus clopidogrel in CYP2C19 loss-of-function carriers with stroke or TIA?
What is the primary focus of PharmVar GeneFocus?
What is the primary focus of PharmVar GeneFocus?
What is the primary function of the CYP2D6 and CYP2C19 genes?
What is the primary function of the CYP2D6 and CYP2C19 genes?
What is the primary focus of the Genetics of Hypertension Associated Treatment (GenHAT) study?
What is the primary focus of the Genetics of Hypertension Associated Treatment (GenHAT) study?
What is the main finding of the study by Maranville and Cox?
What is the main finding of the study by Maranville and Cox?
What is the primary goal of genome-wide association studies (GWAS) in pharmacogenomics?
What is the primary goal of genome-wide association studies (GWAS) in pharmacogenomics?
What is the primary focus of the study by Hawcutt et al?
What is the primary focus of the study by Hawcutt et al?
What is the primary finding of the meta-analysis by Koopmans et al?
What is the primary finding of the meta-analysis by Koopmans et al?
What is the title of the report written by the Royal College of Physicians and British Pharmacological Society?
What is the title of the report written by the Royal College of Physicians and British Pharmacological Society?
In what year was the paper 'Pharmacogenomics in the UK National Health Service: opportunities and challenges' published?
In what year was the paper 'Pharmacogenomics in the UK National Health Service: opportunities and challenges' published?
What is the name of the model for the clinical implementation of pre-emptive pharmacogenetics?
What is the name of the model for the clinical implementation of pre-emptive pharmacogenetics?
What is the title of the paper written by van der Wouden et al.?
What is the title of the paper written by van der Wouden et al.?
In what journal was the paper by Hoffman et al. published?
In what journal was the paper by Hoffman et al. published?
What is the title of the paper by Matey et al.?
What is the title of the paper by Matey et al.?
What is the primary concern with DGAT1 inhibition using AZD7687?
What is the primary concern with DGAT1 inhibition using AZD7687?
What is the purpose of biobanks and electronic medical records in research?
What is the purpose of biobanks and electronic medical records in research?
What is the association between the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene and cataract risk?
What is the association between the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene and cataract risk?
What is the significance of the HLA-B*55:01 allele in relation to penicillin allergy?
What is the significance of the HLA-B*55:01 allele in relation to penicillin allergy?
What is the use of genome-wide association studies in the context of drug development?
What is the use of genome-wide association studies in the context of drug development?
What is the purpose of vemurafenib in the treatment of advanced melanoma?
What is the purpose of vemurafenib in the treatment of advanced melanoma?
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