Pharmacodynamics of Local Anesthetics

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Questions and Answers

Which of the following is a characteristic of local anesthetics?

  • They are more effective in inflamed tissue
  • They can only cross the hydrophobic neuron membrane in their non-ionized form
  • They block sodium channels in neurons (correct)
  • They have a shorter duration of action with increased protein binding

What is the effect of excess H+ ions in inflamed tissue on the effectiveness of local anesthetics?

  • It increases the potency of local anesthetics
  • It increases the duration of action of local anesthetics (correct)
  • It has no effect on the effectiveness of local anesthetics
  • It decreases the duration of action of local anesthetics

What is the critical length required for complete anesthesia with local anesthetics?

  • 1 node of Ranvier
  • 3 nodes of Ranvier (correct)
  • 2 nodes of Ranvier
  • 4 nodes of Ranvier

What is the relationship between lipid solubility/hydrophobicity and the potency and duration of action of local anesthetics?

<p>Increased lipid solubility/hydrophobicity leads to increased potency and duration of action (B)</p> Signup and view all the answers

What is the effect of increased blood flow on the duration of action of local anesthetics?

<p>It decreases the duration of action (A)</p> Signup and view all the answers

Which of the following is the maximum dosage limit for Lidocaine without epinephrine?

<p>4.5mg/kg (B)</p> Signup and view all the answers

What is the concentration of a local anesthetic in a 100% solution?

<p>1800mg (C)</p> Signup and view all the answers

How much local anesthetic is there in a carpule/cartridge?

<p>1.8mL (A)</p> Signup and view all the answers

What is the maximum dosage limit for Articaine with epinephrine?

<p>7mg/kg (C)</p> Signup and view all the answers

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