Pharmacodynamics of Local Anesthetics
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Questions and Answers

Which of the following is a characteristic of local anesthetics?

  • They are more effective in inflamed tissue
  • They can only cross the hydrophobic neuron membrane in their non-ionized form
  • They block sodium channels in neurons (correct)
  • They have a shorter duration of action with increased protein binding

    • What is the effect of excess H+ ions in inflamed tissue on the effectiveness of local anesthetics?

  • It increases the potency of local anesthetics
  • It increases the duration of action of local anesthetics (correct)
  • It has no effect on the effectiveness of local anesthetics
  • It decreases the duration of action of local anesthetics

    • What is the critical length required for complete anesthesia with local anesthetics?

  • 1 node of Ranvier
  • 3 nodes of Ranvier (correct)
  • 2 nodes of Ranvier
  • 4 nodes of Ranvier

    • What is the relationship between lipid solubility/hydrophobicity and the potency and duration of action of local anesthetics?

    <p>Increased lipid solubility/hydrophobicity leads to increased potency and duration of action</p> Signup and view all the answers

    What is the effect of increased blood flow on the duration of action of local anesthetics?

    <p>It decreases the duration of action</p> Signup and view all the answers

    Which of the following is the maximum dosage limit for Lidocaine without epinephrine?

    <p>4.5mg/kg</p> Signup and view all the answers

    What is the concentration of a local anesthetic in a 100% solution?

    <p>1800mg</p> Signup and view all the answers

    How much local anesthetic is there in a carpule/cartridge?

    <p>1.8mL</p> Signup and view all the answers

    What is the maximum dosage limit for Articaine with epinephrine?

    <p>7mg/kg</p> Signup and view all the answers

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