Pharmacodynamics Lecture Outline Quiz
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Questions and Answers

What is the function of the lock-and-key hypothesis in pharmacodynamics?

  • To show the effects of substrate binding to the allosteric site
  • To explain the concept of Efficacy vs Potency among agonists
  • To describe how a substrate fits into the active site of a protein (correct)
  • To illustrate the competitive vs non-competitive inhibitions

    • What encodes the 20 different amino acids in the human body?

  • Polypeptides
  • Codons (correct)
  • DNA/mRNA chain
  • Nucleotides

    • What is the primary role of proteins in pharmacodynamics?

  • To regulate receptor activity levels
  • To exhibit competitive inhibitions
  • To affect substrate-protein binding (correct)
  • To encode amino acids through polypeptide chains

    • How do substrates bind to proteins at the allosteric site?

    <p>By altering protein conformation and function (B)</p> Signup and view all the answers

    What do competitive vs non-competitive inhibitions refer to in pharmacodynamics?

    <p>The manner in which substrates inhibit protein activity (C)</p> Signup and view all the answers

    What is the main concept behind Efficacy vs Potency among agonists in pharmacodynamics?

    <p>The strength of the response produced by an agonist vs its concentration needed for effect (B)</p> Signup and view all the answers

    What is the main function of insulin?

    <p>Regulate blood sugar levels (C)</p> Signup and view all the answers

    What happens to proteins when they denature at extreme pH or temperature?

    <p>They lose their shape and therefore their function (B)</p> Signup and view all the answers

    According to the lock-and-key hypothesis, what is required for a protein to exhibit its activity?

    <p>A specific substrate of the same shape (A)</p> Signup and view all the answers

    What is the effect of a substrate binding to the active site termed as?

    <p>Competitive binding (C)</p> Signup and view all the answers

    What type of receptor proteins are located on the cell membrane?

    <p>Transmembrane receptors (B)</p> Signup and view all the answers

    What does molecular polarity affect in substrate-protein affinity?

    <p>Reversible binding (B)</p> Signup and view all the answers

    Which type of substrate binds to the active site and competes for the same site?

    <p>Competitive antagonist (A)</p> Signup and view all the answers

    What is the main effect of substrates that bind to the active site and compete for the same site?

    <p>Maximum activity level from our body (A)</p> Signup and view all the answers

    What classifies substrates that bind to the active site and compete for the same site?

    <p>Competitive antagonist (A)</p> Signup and view all the answers

    What is the main function of hemoglobin?

    <p>Transport oxygen (C)</p> Signup and view all the answers

    What is the relationship between nucleotides and codons in DNA/mRNA?

    <p>Every 3 nucleotides form a codon (C)</p> Signup and view all the answers

    How many different amino acids do the 64 codons in our DNA/mRNA chain encode?

    <p>20 different amino acids (B)</p> Signup and view all the answers

    What do many amino acids link together in a line to form?

    <p>Polypeptides (C)</p> Signup and view all the answers

    What do polypeptides link and entwine together to form?

    <p>Proteins (B)</p> Signup and view all the answers

    What is the function of the lock-and-key hypothesis in pharmacodynamics?

    <p>To describe the interaction between substrates and proteins (A)</p> Signup and view all the answers

    What is the term for the concept of Efficacy vs Potency among antagonists in pharmacodynamics?

    <p>Competitive vs non-competitive inhibitions (D)</p> Signup and view all the answers

    What is the main concept behind the lock-and-key hypothesis in relation to proteins?

    <p>Proteins require a substrate of specific shape(s) to exhibit their activity (C)</p> Signup and view all the answers

    What is the effect of substrates that bind to the active site and compete for the same site?

    <p>Full inverse agonist (D)</p> Signup and view all the answers

    What happens when proteins denature at extreme pH or temperature?

    <p>Proteins lose their specific shape and function (B)</p> Signup and view all the answers

    What encodes the 20 different amino acids in the human body?

    <p>genetic code (D)</p> Signup and view all the answers

    What classifies substrates that bind to the active site and compete for the same site?

    <p>Competitive inhibitors (A)</p> Signup and view all the answers

    What is the primary role of proteins in pharmacodynamics?

    <p>Acting as enzymes/channels/receptors (D)</p> Signup and view all the answers

    According to the text, what is required for a protein to exhibit its activity?

    <p>Specific shape of the protein (A)</p> Signup and view all the answers

    What type of receptor proteins are located on the cell membrane?

    <p>(Cell membrane) receptor proteins (B)</p> Signup and view all the answers

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