30 Questions
What is the function of the lock-and-key hypothesis in pharmacodynamics?
To describe how a substrate fits into the active site of a protein
What encodes the 20 different amino acids in the human body?
Codons
What is the primary role of proteins in pharmacodynamics?
To affect substrate-protein binding
How do substrates bind to proteins at the allosteric site?
By altering protein conformation and function
What do competitive vs non-competitive inhibitions refer to in pharmacodynamics?
The manner in which substrates inhibit protein activity
What is the main concept behind Efficacy vs Potency among agonists in pharmacodynamics?
The strength of the response produced by an agonist vs its concentration needed for effect
What is the main function of insulin?
Regulate blood sugar levels
What happens to proteins when they denature at extreme pH or temperature?
They lose their shape and therefore their function
According to the lock-and-key hypothesis, what is required for a protein to exhibit its activity?
A specific substrate of the same shape
What is the effect of a substrate binding to the active site termed as?
Competitive binding
What type of receptor proteins are located on the cell membrane?
Transmembrane receptors
What does molecular polarity affect in substrate-protein affinity?
Reversible binding
Which type of substrate binds to the active site and competes for the same site?
Competitive antagonist
What is the main effect of substrates that bind to the active site and compete for the same site?
Maximum activity level from our body
What classifies substrates that bind to the active site and compete for the same site?
Competitive antagonist
What is the main function of hemoglobin?
Transport oxygen
What is the relationship between nucleotides and codons in DNA/mRNA?
Every 3 nucleotides form a codon
How many different amino acids do the 64 codons in our DNA/mRNA chain encode?
20 different amino acids
What do many amino acids link together in a line to form?
Polypeptides
What do polypeptides link and entwine together to form?
Proteins
What is the function of the lock-and-key hypothesis in pharmacodynamics?
To describe the interaction between substrates and proteins
What is the term for the concept of Efficacy vs Potency among antagonists in pharmacodynamics?
Competitive vs non-competitive inhibitions
What is the main concept behind the lock-and-key hypothesis in relation to proteins?
Proteins require a substrate of specific shape(s) to exhibit their activity
What is the effect of substrates that bind to the active site and compete for the same site?
Full inverse agonist
What happens when proteins denature at extreme pH or temperature?
Proteins lose their specific shape and function
What encodes the 20 different amino acids in the human body?
genetic code
What classifies substrates that bind to the active site and compete for the same site?
Competitive inhibitors
What is the primary role of proteins in pharmacodynamics?
Acting as enzymes/channels/receptors
According to the text, what is required for a protein to exhibit its activity?
Specific shape of the protein
What type of receptor proteins are located on the cell membrane?
(Cell membrane) receptor proteins
Test your understanding of pharmacodynamics with this quiz based on the lecture outline of NURS1125 Pharmacology by Matthew Hui. The quiz covers topics such as protein and substrate interactions, lock-and-key hypothesis, types of proteins, factors affecting substrate-protein binding, and effects of substrate binding.
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