20 Questions
Which type of inhibition is characterized by drug binding to the enzyme site only after the substrate binds?
Uncompetitive inhibition
Which enzyme target is associated with the clinical use of ACE inhibitors like captopril?
Angiotensin converting enzyme
Which transporter family utilizes energy derived from downhill movement of a solute to transport molecules in secondary active transport?
Solute-carrier (SLC) family
Which transporter, also known as MDR1 transporter, affects the pharmacokinetics of drugs by affecting entry and exit from selective tissues?
P-glycoprotein (P-gp) efflux pumps
Which type of secondary active transporters use the flow of one molecule/ion to move another in the opposite direction?
Antiporters
Which type of ion channels open and close depending on transmembrane potentials?
Voltage-gated ion channels
Which drug is classified as a calcium channel blocker?
Amlodipine
Which type of enzyme inhibition is characterized by the drug binding to the allosteric site?
Non-competitive inhibition
What effect can be observed by increasing the substrate concentration in competitive enzyme inhibition?
Reduction in inhibitor effects
Which drug is classified as a sodium channel blocker used as a local anesthetic?
Lignocaine
Which type of inhibition is characterized by the drug binding to the allosteric site?
Uncompetitive inhibition
Which drug is classified as a potassium channel blocker used for antiarrhythmic purposes?
Amiodarone
Which type of ion channels open and close depending on transmembrane potentials?
Voltage-gated ion channels
Which enzyme inhibition type is characterized by the effects of the inhibitor being reduced by increasing substrate concentration?
Competitive inhibition
Which drug is classified as a calcium channel blocker used as an antihypertensive?
Diltiazem
Which of the following statements best characterizes uncompetitive inhibition?
The drug binds to the enzyme site only after the substrate binds, with minimal displacement and decreased Vmax
Which enzyme target is associated with the clinical use of HMG-CoA reductase inhibitors like atorvastatin and rosuvastatin?
HMG-CoA reductase
Which transporter family utilizes energy from ATP hydrolysis to actively move ions or drug molecules against their electrochemical gradient?
ATP-Binding Cassette (ABC) superfamily of transporters
Which type of transporters use the natural flow of one molecule/ion to move another in the same direction against its electrochemical gradient?
Symporters (Cotransporters)
Which type of enzyme inhibition is characterized by drug binding to the enzyme site only after the substrate binds, with minimal displacement and decreased Vmax?
Uncompetitive inhibition
Test your knowledge of ion channels and drugs that target them in pharmacodynamics. This quiz covers topics like ligand-gated ion channels, voltage-gated ion channels, and examples of drugs that act on calcium, potassium, sodium, and chloride channels.
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