Pharmacodynamics: Main Targets of Drugs Quiz

Nicotinic receptors are examples of G-protein coupled receptors

Ligand-gated ion channels are involved in slow synaptic transmission

G-protein consists of 4 subunits: α, β, γ, and δ subunits with GDP bound to the α subunit

Dopamine receptors are examples of G-protein coupled receptors

The effector systems for G-proteins include ion channels

Muscarinic acetylcholine receptors are examples of G-protein coupled receptors

Enzyme-linked receptors regulate the flow of ions across the cell membrane

G-protein consists of 3 subunits: α, β, and γ subunits with GDP bound to the α subunit

Ligand-gated ion channels are involved in fast synaptic transmission (milliseconds)

The effector systems for G-proteins include the adenylate cyclase/cAMP system

Nicotinic and Muscarinic Receptors

Nicotinic receptors are a type of ligand-gated ion channel that mediate fast synaptic transmission, functioning within milliseconds.
Muscarinic acetylcholine receptors are classified as G-protein coupled receptors (GPCRs), playing a crucial role in the parasympathetic nervous system.

G-Protein Structure and Function

G-proteins are composed of three subunits: α, β, and γ, with GDP bound to the α subunit in its inactive state.
The activation of GPCRs leads to the dissociation of the G-protein subunits, which can then interact with various effector systems.

Types of G-Protein Coupled Receptors

Dopamine receptors belong to the class of G-protein coupled receptors, influencing various physiological processes including mood and reward mechanisms.
G-proteins facilitate communication between receptors and effector systems, which can include ion channels and enzymes.

Effector Systems

G-protein effector systems include ion channels, which mediate cellular responses to neurotransmitter binding.
The adenylate cyclase/cAMP system is another key effector pathway activated by G-proteins, regulating many biological processes.

Ion Channels and Transmission Types

Ligand-gated ion channels play a significant role in fast synaptic transmission, allowing rapid changes in membrane potential.
In contrast, GPCR-linked pathways typically mediate slower synaptic transmission, regulating longer-lasting physiological effects.

Test your knowledge of pharmacodynamics and the main targets of drugs, including receptors, ion channels, enzymes, and carrier molecules. Identify the different types of receptors and their regulation, such as ligand-gated ion channels and enzyme-linked receptors.