Pharmaceutical Chemistry Quiz

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Questions and Answers

Which constituent is derived from hydrolysis of Arabic acid?

  • D-mannose
  • L-arabinose (correct)
  • L-xylose
  • D-fructose

What is one disadvantage of using the oxidase enzyme present in certain preparations?

  • It enhances the destruction of certain pharmaceutical products. (correct)
  • It improves shelf life capabilities.
  • It enhances the therapeutic effect.
  • It increases the viscosity of solutions.

Which substance is known to contain about 5% methoxyl groups?

  • Bassorin (correct)
  • L-arabinose
  • Tragacanthin
  • Arabic acid

In which conditions is Tragacanth preferred due to its chemical properties?

<p>Highly acidic conditions (B)</p> Signup and view all the answers

What is NOT a use of Tragacanth?

<p>Antibiotic preparation (D)</p> Signup and view all the answers

What is the minimum concentration of morphine required in opium?

<p>10% (D)</p> Signup and view all the answers

What should be avoided when making incisions in opium capsules?

<p>Penetrating the endocarp (D)</p> Signup and view all the answers

What substance rapidly coagulates and turns brown when exuded?

<p>Milky latex (A)</p> Signup and view all the answers

What is the role of codeine in opium?

<p>It is a narcotic alkaloid. (B)</p> Signup and view all the answers

Which alkaloids are derived from Papaver somniferum?

<p>Opiates like morphine and codeine (A)</p> Signup and view all the answers

What process is conducted on the latex collected in the morning?

<p>It is scraped, dried, and manipulated. (A)</p> Signup and view all the answers

What defines an opioid in contrast to opiates?

<p>Opioids include natural and synthetic compounds. (A)</p> Signup and view all the answers

What group are morphine and codeine classified into?

<p>Phenanthrene group (D)</p> Signup and view all the answers

What is the primary use of agar-agar in pharmacy?

<p>Suspending, thickening, and emulsifying agent (B)</p> Signup and view all the answers

Which of the following indicates that agar-agar is present in a sample when tested with N/50 iodine solution?

<p>Crimson red color (A)</p> Signup and view all the answers

What is gelatin primarily derived from?

<p>Insoluble collagenous by-products (B)</p> Signup and view all the answers

What type of nutrient is gelatin primarily considered to be?

<p>Incomplete nutrient (C)</p> Signup and view all the answers

Which chemical test can be used to detect gelatin?

<p>Soda lime to yield ammonia odor (A)</p> Signup and view all the answers

Which of the following is NOT a use of agarose?

<p>Thickening agent in soups (D)</p> Signup and view all the answers

What occurs if gelatin is mixed with mineral acids?

<p>No turbidity observed (A)</p> Signup and view all the answers

What is one of the significant clinical uses of gelatin?

<p>Haemostatic dressing (D)</p> Signup and view all the answers

What is a significant characteristic of morphine regarding its effects on respiration?

<p>It causes respiratory depression. (D)</p> Signup and view all the answers

Which of the following correctly describes heroin?

<p>It is a synthetic compound derived from morphine. (A)</p> Signup and view all the answers

What role does papaverine play among the alkaloids mentioned?

<p>It's a smooth muscle relaxant. (B)</p> Signup and view all the answers

How is dependence on heroin typically established?

<p>Due to its lipophilic properties allowing easy brain entry. (A)</p> Signup and view all the answers

Which condition might be treated with codeine as mentioned in the content?

<p>Dry cough. (B)</p> Signup and view all the answers

What is the initial step in the test for meconic acid as described?

<p>Shake the powdered drug with water. (A)</p> Signup and view all the answers

Which of the following statements about heroin is incorrect?

<p>Heroin is legal in many countries. (D)</p> Signup and view all the answers

Among these effects, which is NOT associated with morphine?

<p>Pupil dilation. (D)</p> Signup and view all the answers

What is the process called that leads to the formation of gums in plants after injury?

<p>Gummosis (C)</p> Signup and view all the answers

Which of the following is NOT a use of gums mentioned?

<p>Antioxidants (B)</p> Signup and view all the answers

What characteristic of gums makes them generally insoluble in organic solvents?

<p>They are hydrophobic in nature. (A)</p> Signup and view all the answers

Which of the following examples is classified as a gum?

<p>Gum Tragacanth (D)</p> Signup and view all the answers

What are gums primarily produced as in response to?

<p>Plant injury (D)</p> Signup and view all the answers

What is the primary characteristic of juices as described?

<p>They are fluid plant saps composed of aqueous liquid containing dissolved substances. (A)</p> Signup and view all the answers

Which type of polysaccharide are gums classified as?

<p>Heterogeneous polysaccharides (D)</p> Signup and view all the answers

What is required for preparing Aloe juice?

<p>The leaf must be cut transversely and the juice boiled for concentration. (D)</p> Signup and view all the answers

Which of these types of solutions can gums form when mixed with water?

<p>Viscous colloidal solution (B)</p> Signup and view all the answers

Which plant species is known for yielding a type of gum exudate?

<p>Acacia senegal (B)</p> Signup and view all the answers

Which chemical test involves aglycones turning a rose red color?

<p>Bornträger test (A)</p> Signup and view all the answers

What percentage of hydroxy anthracene derivatives does Aloe juice contain?

<p>Not less than 28% (D)</p> Signup and view all the answers

Which type of substances can be found in juice extracted from plants?

<p>Aqueous liquid with dissolved substances (B)</p> Signup and view all the answers

What method is used to achieve the free aglycones in the modified Bornträger test?

<p>Oxidative hydrolysis using FeCl3/HCl (B)</p> Signup and view all the answers

What is the main use of latex as indicated in the classification?

<p>As an adhesive and source of rubber (B)</p> Signup and view all the answers

Which of the following substances is correctly classified as an extract?

<p>Opium (D)</p> Signup and view all the answers

Flashcards

What is opium?

Opium is a mixture of alkaloids extracted from the opium poppy plant (Papaver somniferum).

What is an opiate?

An opiate refers to any of the naturally occurring narcotic alkaloids found in the opium poppy plant, such as morphine and codeine.

What is an opioid?

An opioid encompasses any compound, both natural and synthetic, that has morphine-like actions.

What are endogenous opioid peptides?

Endogenous opioid peptides are natural peptides discovered in the brain that exhibit morphine-like actions. Examples include enkephalins and endorphins.

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What is the minimum content of morphine and codeine in opium?

Opium contains a minimum of 10% morphine and 2% codeine.

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How is opium collected?

Incisions are made in the green capsules of the poppy plant using special knives, typically in the afternoon.

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What happens to the collected opium latex?

Latex is collected from poppy capsules by making incisions. It is then dried and shaped, often surrounded by poppy leaves.

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How do opium's alkaloids exist?

The alkaloids in opium exist in combination with the organic acid meconic acid.

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Morphine

A potent pain reliever used for cancer pain and before and after anesthesia. It also has antidiarrheal properties but can cause constipation. It's known to be addictive and can depress the respiratory system. It also constricts eye pupils and slightly decreases body temperature and sweating.

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Heroin

A highly addictive illegal drug derived from morphine. It was initially promoted as a less respiratory-depressing alternative to morphine., but it has proven to be one of the most addictive substances.

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Codeine

A type of alkaloid found in opium, known for its cough-suppressing effects. It has a short duration of action.

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Papaverine

A non-addictive alkaloid from opium that acts as a smooth muscle relaxant, affecting the digestive tract and reducing coughing. It also dilates blood vessels in the brain (cerebral) and body (peripheral).

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Alkaloids

A group of naturally occurring compounds found in plants. They're often potent and have various medicinal properties.

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Meconic Acid Test

A test used to identify opium and its derivatives.

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Lipophilic

The property of a drug allowing it to pass through the blood-brain barrier easily. This leads to faster and stronger effects.

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Dependence

A physical or psychological dependence on a drug, often accompanied by withdrawal symptoms when the substance isn't used.

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What is Agaropectin?

A component of agar-agar that doesn't form a gel, but influences the solution's viscosity. It's made up of uronic acid with some sulfate groups.

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How can you identify agar-agar using an iodine solution?

A reddish-purple color indicates the presence of agar-agar when a powder of it is mixed with a specific iodine solution.

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What are the primary uses of agar-agar in pharmacy?

Agar-agar is a natural compound widely used in various fields as a suspending, thickening, and emulsifying agent.

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What is a key role of agar-agar in bacteriology?

Agar-agar serves as a nutrient medium for growing bacteria and other microorganisms in labs.

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What is the source of Gelatin?

Gelatin is a protein derived from breaking down collagen found in animal products like skin, bones, and tendons.

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What's the main protein in gelatin and why is it nutritionally incomplete?

Gelatin is primarily made up of a protein called glutin, which has 19 amino acids but lacks certain essential ones, making it an incomplete source of protein.

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What happens when gelatin is mixed with tannic acid?

Gelatin forms a white precipitate when mixed with tannic acid.

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What are some pharmaceutical uses of gelatin?

Gelatin can be used as a suspending, stabilizing, and thickening agent in making various pharmaceutical products.

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Tragacanth

A natural gum obtained from the Astragalus gummifer plant, belonging to the legume family. It contains a water-soluble fraction called Tragacanthin and a water-insoluble fraction called Bassorin.

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Tragacanthin

The water-soluble fraction of Tragacanth gum, which does not contain any methoxyl groups.

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Bassorin

The water-insoluble fraction of Tragacanth gum, containing about 5% methoxyl groups.

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Arabin

A naturally occurring gum that is a calcium salt of Arabic acid.

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Oxidase enzyme

An enzyme found in Gum arabic.

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What are gums?

Gums are complex carbohydrates produced by plants in response to injury or stress. They are typically made of sugar molecules combined with uronic acids.

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Give an example of a gum.

Gums are commonly found in natural products like Acacia gum or Guar gum.

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How are gums formed?

The process of gum formation is called gummosis, where enzymes break down the plant cell wall.

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What are some common uses for gums?

Gums are often used in pharmaceutical formulations to create films, stabilize suspensions, and thicken liquids.

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What are the solubility properties of gums?

They are insoluble in most organic solvents, meaning they won't dissolve in oily substances.

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How do gums interact with water?

They can either dissolve in water or form a viscous solution, creating a thick, syrup-like consistency.

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What other effects can gums have in water?

Gums might also form jelly-like masses, acting as a gelling agent.

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Why are gums important in pharmacy?

Gums are widely used in pharmaceuticals for various purposes, including film coating, suspending agents, and stabilizers.

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What are plant juices?

Plant juices are fluid saps composed of water and dissolved substances. They are found within plant cells (e.g., aloe) or cavities (e.g., oranges). After extraction, they are dried by evaporating the water content.

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What are aloes?

Aloes are a specific kind of plant juice extracted from the leaves of Aloe plants. It's a concentrated and dried form, containing at least 28% special compounds called hydroxyanthracene derivatives.

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How are aloes prepared?

To prepare aloes juice, the Aloe leaves are cut transversely, and the juice is collected. The collected juice is then boiled to concentrate it, removing the excess water.

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What is the Bornträger test?

A chemical test used to identify aloes. The aglycones (active ingredients in aloes) turn rose red when reacting with certain chemicals.

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What is the Modified Bornträger test?

A modified version of the Bornträger test where aloes are treated with FeCl3/HCl to break down the aglycones into simpler compounds.

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Study Notes

Unorganized Drugs

  • Classification is based on physical characteristics
  • Latex: Opium
  • Extracts: Agar, Gelatin
  • Juice: Aloes
  • Resin and resin combinations
  • Balsams: Benzoin, Tolu balsam
  • Gums: Gum Acacia, Gum Tragacanth, Guar gum
  • Saccharin derivatives: Honey, Bee propolis, Bee venom, Royal jelly
  • Resin: Colophony
  • Oleo-gum-resin: Myrrh, Olibanum, Guggul, Asafoetida

Opium

  • Air-dried latex from unripe Papaver somniferum L. capsules
  • Contains at least 10% morphine and 2% codeine
  • Collection and preparation:
    • Incisions made on green capsules in the afternoon
    • Milk latex rapidly coagulates and turns brown
  • Opium is a mixture of alkaloids derived from Papaver somniferum
  • An Opiate: Naturally occurring narcotic alkaloids in opium poppy plant (e.g., morphine, codeine)
  • An Opioid: Any natural or synthetic compound with morphine-like action (e.g., enkephalins, endorphins)

Alkaloids

  • Combined with meconic acid

  • Phenanthrene group:

    • Morphine: Most effective pain killer (cancer, pre/post-anesthesia), antiperistaltic (constipation), respiratory depressant, addictive, constricts pupils, slightly lowers temperature
    • Heroin (Diacetyl morphine): Illegal highly addictive substitute for morphine, strongly lipophilic, rapidly crosses the blood-brain barrier, highly addictive
  • Benzyl isoquinoline alkaloids:

    • Papaverine: Non-addictive, smooth muscle relaxant (GIT, cough), cerebral and peripheral vasodilator
  • Phenyl alkyl amines:

    • Narceine

Tests for Identity

  • Meconic acid:
    • Combine 1g powdered drug with 5ml water, shake, and filter
    • To filtrate add 0.25ml ferric chloride solution
    • Red color develops, which doesn’t disappear upon addition of 0.5ml dilute hydrochloric acid
  • Morphine:
    • Evaporate 1ml filtrate to dryness
    • Add 1 drop formaldehyde and 2 drops Hâ‚‚SOâ‚„ to residue
    • Crimson red color production

Extracts

  • Agar-agar (Japanese Isinglass):
    • Polysaccharides from various species of Rhodophyceae (red algae), mainly genus Gelidium
    • Collected, bleached, treated with boiling water, concentrated, dried, then cut
    • Constituents: Agarose (neutral gelling), Agaropectin (non-gelling, affects viscosity), component of uronic acid, partially esterified with sulphuric acid
    • Uses: Suspending/thickening agent, emulsifier, laxative, bacteriological cultures, electrophoresis/chromatography gel filtration
  • Gelatin:
    • Soluble protein produced via hydrolysis from insoluble collagenous by-products of meat industry (skin, bones, tendons)
    • Contains protein called glutin, 19 amino acids, but lacks some essential amino acids and is thus incomplete as a nutrient
    • Uses: Suppositories, tablets, hard gelatin capsules, suspending agent, stabilizing agent, thickening agent, microencapsulation, bacteriological culture medium, plasma substitute, hemostatic dressing

Gums

  • Hydrocolloids, either anionic or nonionic
  • Polysaccharides, produced by plants as protective products or in unfavorable growth conditions
  • Heterogenous polysaccharides with various sugars on hydrolysis (besides glucose)
  • Formed from cell walls through enzymatic action (gummosis)
  • Insoluble in most organic solvents
  • Gelling agents and suspending agents, useful in suspensions, film coatings, etc
  • Gum Acacia:
    • Air-dried gummy exudate from Acacia senegal (Fabaceae)
    • Constituents: Arabic acid (e.g., calcium salt of Arabic acid), hydrolysis yields L-arabinose, D-galactose, D-glucuronic acid, L-rhamnose, oxidase enzyme
    • Uses: Suspending agent, cough and cold preparations, wound healing, catarrh and diarrhea treatment
  • Gum Tragacanth:
    • Air-dried gummy exudate from Astragalus gummifer (Fabaceae)
    • Constituents: Tragacanthin (water-soluble), bassorin (water-insoluble, contains methoxyl groups)
    • Uses: Suspending agent, binder in cosmetics, solutions with high viscosity, highly resistant to acidity -Guar Gum:
    • Obtained from Cyamopsis tetrogonolobus Leguminoseae seeds
    • Components: Galactomannan polysaccharide via hydrolysis that yields galactose and mannose, protein, saponin
    • Uses: Tablet binder, suspending agent, laxative, handling blood glucose

Juices

  • Fluid plant saps
  • Aqueous liquid with dissolved substances in cells, cavities (orange/aloe)
  • Dried by water evaporation
  • Aloe:
    • Concentrated and dried juice from Aloe species (Liliaceae)
    • Contains hydroxy anthracene derivatives (e.g., barbaloin) above 28%
    • Uses: Stimulant laxative (gripping effect, carminative/antispasmodic), antiseptic, antibacterial, wound healing, burns, treats respiratory disorders

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