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Questions and Answers
Which constituent is derived from hydrolysis of Arabic acid?
Which constituent is derived from hydrolysis of Arabic acid?
- D-mannose
- L-arabinose (correct)
- L-xylose
- D-fructose
What is one disadvantage of using the oxidase enzyme present in certain preparations?
What is one disadvantage of using the oxidase enzyme present in certain preparations?
- It enhances the destruction of certain pharmaceutical products. (correct)
- It improves shelf life capabilities.
- It enhances the therapeutic effect.
- It increases the viscosity of solutions.
Which substance is known to contain about 5% methoxyl groups?
Which substance is known to contain about 5% methoxyl groups?
- Bassorin (correct)
- L-arabinose
- Tragacanthin
- Arabic acid
In which conditions is Tragacanth preferred due to its chemical properties?
In which conditions is Tragacanth preferred due to its chemical properties?
What is NOT a use of Tragacanth?
What is NOT a use of Tragacanth?
What is the minimum concentration of morphine required in opium?
What is the minimum concentration of morphine required in opium?
What should be avoided when making incisions in opium capsules?
What should be avoided when making incisions in opium capsules?
What substance rapidly coagulates and turns brown when exuded?
What substance rapidly coagulates and turns brown when exuded?
What is the role of codeine in opium?
What is the role of codeine in opium?
Which alkaloids are derived from Papaver somniferum?
Which alkaloids are derived from Papaver somniferum?
What process is conducted on the latex collected in the morning?
What process is conducted on the latex collected in the morning?
What defines an opioid in contrast to opiates?
What defines an opioid in contrast to opiates?
What group are morphine and codeine classified into?
What group are morphine and codeine classified into?
What is the primary use of agar-agar in pharmacy?
What is the primary use of agar-agar in pharmacy?
Which of the following indicates that agar-agar is present in a sample when tested with N/50 iodine solution?
Which of the following indicates that agar-agar is present in a sample when tested with N/50 iodine solution?
What is gelatin primarily derived from?
What is gelatin primarily derived from?
What type of nutrient is gelatin primarily considered to be?
What type of nutrient is gelatin primarily considered to be?
Which chemical test can be used to detect gelatin?
Which chemical test can be used to detect gelatin?
Which of the following is NOT a use of agarose?
Which of the following is NOT a use of agarose?
What occurs if gelatin is mixed with mineral acids?
What occurs if gelatin is mixed with mineral acids?
What is one of the significant clinical uses of gelatin?
What is one of the significant clinical uses of gelatin?
What is a significant characteristic of morphine regarding its effects on respiration?
What is a significant characteristic of morphine regarding its effects on respiration?
Which of the following correctly describes heroin?
Which of the following correctly describes heroin?
What role does papaverine play among the alkaloids mentioned?
What role does papaverine play among the alkaloids mentioned?
How is dependence on heroin typically established?
How is dependence on heroin typically established?
Which condition might be treated with codeine as mentioned in the content?
Which condition might be treated with codeine as mentioned in the content?
What is the initial step in the test for meconic acid as described?
What is the initial step in the test for meconic acid as described?
Which of the following statements about heroin is incorrect?
Which of the following statements about heroin is incorrect?
Among these effects, which is NOT associated with morphine?
Among these effects, which is NOT associated with morphine?
What is the process called that leads to the formation of gums in plants after injury?
What is the process called that leads to the formation of gums in plants after injury?
Which of the following is NOT a use of gums mentioned?
Which of the following is NOT a use of gums mentioned?
What characteristic of gums makes them generally insoluble in organic solvents?
What characteristic of gums makes them generally insoluble in organic solvents?
Which of the following examples is classified as a gum?
Which of the following examples is classified as a gum?
What are gums primarily produced as in response to?
What are gums primarily produced as in response to?
What is the primary characteristic of juices as described?
What is the primary characteristic of juices as described?
Which type of polysaccharide are gums classified as?
Which type of polysaccharide are gums classified as?
What is required for preparing Aloe juice?
What is required for preparing Aloe juice?
Which of these types of solutions can gums form when mixed with water?
Which of these types of solutions can gums form when mixed with water?
Which plant species is known for yielding a type of gum exudate?
Which plant species is known for yielding a type of gum exudate?
Which chemical test involves aglycones turning a rose red color?
Which chemical test involves aglycones turning a rose red color?
What percentage of hydroxy anthracene derivatives does Aloe juice contain?
What percentage of hydroxy anthracene derivatives does Aloe juice contain?
Which type of substances can be found in juice extracted from plants?
Which type of substances can be found in juice extracted from plants?
What method is used to achieve the free aglycones in the modified Bornträger test?
What method is used to achieve the free aglycones in the modified Bornträger test?
What is the main use of latex as indicated in the classification?
What is the main use of latex as indicated in the classification?
Which of the following substances is correctly classified as an extract?
Which of the following substances is correctly classified as an extract?
Flashcards
What is opium?
What is opium?
Opium is a mixture of alkaloids extracted from the opium poppy plant (Papaver somniferum).
What is an opiate?
What is an opiate?
An opiate refers to any of the naturally occurring narcotic alkaloids found in the opium poppy plant, such as morphine and codeine.
What is an opioid?
What is an opioid?
An opioid encompasses any compound, both natural and synthetic, that has morphine-like actions.
What are endogenous opioid peptides?
What are endogenous opioid peptides?
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What is the minimum content of morphine and codeine in opium?
What is the minimum content of morphine and codeine in opium?
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How is opium collected?
How is opium collected?
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What happens to the collected opium latex?
What happens to the collected opium latex?
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How do opium's alkaloids exist?
How do opium's alkaloids exist?
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Morphine
Morphine
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Heroin
Heroin
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Codeine
Codeine
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Papaverine
Papaverine
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Alkaloids
Alkaloids
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Meconic Acid Test
Meconic Acid Test
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Lipophilic
Lipophilic
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Dependence
Dependence
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What is Agaropectin?
What is Agaropectin?
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How can you identify agar-agar using an iodine solution?
How can you identify agar-agar using an iodine solution?
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What are the primary uses of agar-agar in pharmacy?
What are the primary uses of agar-agar in pharmacy?
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What is a key role of agar-agar in bacteriology?
What is a key role of agar-agar in bacteriology?
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What is the source of Gelatin?
What is the source of Gelatin?
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What's the main protein in gelatin and why is it nutritionally incomplete?
What's the main protein in gelatin and why is it nutritionally incomplete?
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What happens when gelatin is mixed with tannic acid?
What happens when gelatin is mixed with tannic acid?
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What are some pharmaceutical uses of gelatin?
What are some pharmaceutical uses of gelatin?
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Tragacanth
Tragacanth
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Tragacanthin
Tragacanthin
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Bassorin
Bassorin
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Arabin
Arabin
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Oxidase enzyme
Oxidase enzyme
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What are gums?
What are gums?
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Give an example of a gum.
Give an example of a gum.
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How are gums formed?
How are gums formed?
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What are some common uses for gums?
What are some common uses for gums?
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What are the solubility properties of gums?
What are the solubility properties of gums?
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How do gums interact with water?
How do gums interact with water?
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What other effects can gums have in water?
What other effects can gums have in water?
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Why are gums important in pharmacy?
Why are gums important in pharmacy?
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What are plant juices?
What are plant juices?
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What are aloes?
What are aloes?
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How are aloes prepared?
How are aloes prepared?
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What is the Bornträger test?
What is the Bornträger test?
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What is the Modified Bornträger test?
What is the Modified Bornträger test?
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Study Notes
Unorganized Drugs
- Classification is based on physical characteristics
- Latex: Opium
- Extracts: Agar, Gelatin
- Juice: Aloes
- Resin and resin combinations
- Balsams: Benzoin, Tolu balsam
- Gums: Gum Acacia, Gum Tragacanth, Guar gum
- Saccharin derivatives: Honey, Bee propolis, Bee venom, Royal jelly
- Resin: Colophony
- Oleo-gum-resin: Myrrh, Olibanum, Guggul, Asafoetida
Opium
- Air-dried latex from unripe Papaver somniferum L. capsules
- Contains at least 10% morphine and 2% codeine
- Collection and preparation:
- Incisions made on green capsules in the afternoon
- Milk latex rapidly coagulates and turns brown
- Opium is a mixture of alkaloids derived from Papaver somniferum
- An Opiate: Naturally occurring narcotic alkaloids in opium poppy plant (e.g., morphine, codeine)
- An Opioid: Any natural or synthetic compound with morphine-like action (e.g., enkephalins, endorphins)
Alkaloids
-
Combined with meconic acid
-
Phenanthrene group:
- Morphine: Most effective pain killer (cancer, pre/post-anesthesia), antiperistaltic (constipation), respiratory depressant, addictive, constricts pupils, slightly lowers temperature
- Heroin (Diacetyl morphine): Illegal highly addictive substitute for morphine, strongly lipophilic, rapidly crosses the blood-brain barrier, highly addictive
-
Benzyl isoquinoline alkaloids:
- Papaverine: Non-addictive, smooth muscle relaxant (GIT, cough), cerebral and peripheral vasodilator
-
Phenyl alkyl amines:
- Narceine
Tests for Identity
- Meconic acid:
- Combine 1g powdered drug with 5ml water, shake, and filter
- To filtrate add 0.25ml ferric chloride solution
- Red color develops, which doesn’t disappear upon addition of 0.5ml dilute hydrochloric acid
- Morphine:
- Evaporate 1ml filtrate to dryness
- Add 1 drop formaldehyde and 2 drops Hâ‚‚SOâ‚„ to residue
- Crimson red color production
Extracts
- Agar-agar (Japanese Isinglass):
- Polysaccharides from various species of Rhodophyceae (red algae), mainly genus Gelidium
- Collected, bleached, treated with boiling water, concentrated, dried, then cut
- Constituents: Agarose (neutral gelling), Agaropectin (non-gelling, affects viscosity), component of uronic acid, partially esterified with sulphuric acid
- Uses: Suspending/thickening agent, emulsifier, laxative, bacteriological cultures, electrophoresis/chromatography gel filtration
- Gelatin:
- Soluble protein produced via hydrolysis from insoluble collagenous by-products of meat industry (skin, bones, tendons)
- Contains protein called glutin, 19 amino acids, but lacks some essential amino acids and is thus incomplete as a nutrient
- Uses: Suppositories, tablets, hard gelatin capsules, suspending agent, stabilizing agent, thickening agent, microencapsulation, bacteriological culture medium, plasma substitute, hemostatic dressing
Gums
- Hydrocolloids, either anionic or nonionic
- Polysaccharides, produced by plants as protective products or in unfavorable growth conditions
- Heterogenous polysaccharides with various sugars on hydrolysis (besides glucose)
- Formed from cell walls through enzymatic action (gummosis)
- Insoluble in most organic solvents
- Gelling agents and suspending agents, useful in suspensions, film coatings, etc
- Gum Acacia:
- Air-dried gummy exudate from Acacia senegal (Fabaceae)
- Constituents: Arabic acid (e.g., calcium salt of Arabic acid), hydrolysis yields L-arabinose, D-galactose, D-glucuronic acid, L-rhamnose, oxidase enzyme
- Uses: Suspending agent, cough and cold preparations, wound healing, catarrh and diarrhea treatment
- Gum Tragacanth:
- Air-dried gummy exudate from Astragalus gummifer (Fabaceae)
- Constituents: Tragacanthin (water-soluble), bassorin (water-insoluble, contains methoxyl groups)
- Uses: Suspending agent, binder in cosmetics, solutions with high viscosity, highly resistant to acidity -Guar Gum:
- Obtained from Cyamopsis tetrogonolobus Leguminoseae seeds
- Components: Galactomannan polysaccharide via hydrolysis that yields galactose and mannose, protein, saponin
- Uses: Tablet binder, suspending agent, laxative, handling blood glucose
Juices
- Fluid plant saps
- Aqueous liquid with dissolved substances in cells, cavities (orange/aloe)
- Dried by water evaporation
- Aloe:
- Concentrated and dried juice from Aloe species (Liliaceae)
- Contains hydroxy anthracene derivatives (e.g., barbaloin) above 28%
- Uses: Stimulant laxative (gripping effect, carminative/antispasmodic), antiseptic, antibacterial, wound healing, burns, treats respiratory disorders
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