Podcast
Questions and Answers
What is the title of the book?
What is the title of the book?
Essentials of Pharmaceutical Chemistry
Who is the editor of this book?
Who is the editor of this book?
- Elaine Mairi
- River Valley Technologies
- Andrew
- Donald Cairns (correct)
This is the _____ edition of the book.
This is the _____ edition of the book.
fourth
The book was first published in 2000.
The book was first published in 2000.
What is the ISBN of this book?
What is the ISBN of this book?
What is the main focus of the first chapter?
What is the main focus of the first chapter?
The book is published by _____ Press.
The book is published by _____ Press.
Which of the following is NOT a topic covered in the contents?
Which of the following is NOT a topic covered in the contents?
Flashcards
What is pKa?
What is pKa?
The negative log of the acid dissociation constant (Ka); it indicates the strength of an acid.
What are buffer solutions?
What are buffer solutions?
Solutions that resist changes in pH upon addition of small amounts of acid or base.
What is buffer capacity?
What is buffer capacity?
A measure of the efficiency of a buffer solution in resisting changes in pH.
What is partition coefficient (P)?
What is partition coefficient (P)?
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What is passive diffusion?
What is passive diffusion?
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What is the pH partition hypothesis?
What is the pH partition hypothesis?
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What are Cytochromes P450?
What are Cytochromes P450?
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What are drug conjugation reactions (Phase 2)?
What are drug conjugation reactions (Phase 2)?
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Study Notes
Essentials of Pharmaceutical Chemistry (Fourth Edition)
- Edited by Donald Cairns, BSc, PhD, MRPharmS, CSci, CChem, FRSC.
- Published by Pharmaceutical Press in 2012. Fourth edition.
- Covers topics including acid-base chemistry, partition coefficient, physicochemical properties of drugs, stereochemistry, drug metabolism, and volumetric analysis.
Chapter 1: Chemistry of Acids and Bases
- Explains the dissociation of weak acids and bases.
- Details hydrolysis of salts and amphiprotic salts.
- Covers buffer solutions and buffer capacity, including biological buffers.
- Discusses drug ionization and pKa values.
- Includes pH indicators and tutorial examples with problems for practice.
Chapter 2: Partition Coefficient and Biopharmacy
- Focuses on the experimental measurement of the partition coefficient and its relation to drug absorption, distribution, and bioavailability.
- Explains passive diffusion and the pH partition hypothesis.
- Covers active transport mechanisms, the action of local anesthetics, drug excretion and reabsorption, and the effects of food and drink.
- Includes tutorial examples and practice problems.
Chapter 3: Physicochemical Properties of Drugs
- Examines the properties of various drug classes: carboxylic acids, phenols, warfarin, phenylbutazone, indomethacin, barbiturates, phenytoin, sulfonamides, and basic drugs, including heterocyclic compounds.
- Details the separation of drug mixtures.
- Includes tutorial examples and practice problems.
Chapter 4: Stereochemistry
- Covers polarimetry and its application in biological systems.
- Explains Fischer projections.
- Uses thalidomide as a case study.
- Discusses geometrical isomerism.
- Includes tutorial examples and practice problems.
Chapter 5: Drug Metabolism
- Details metabolic pathways, including the role of Cytochromes P450.
- Explains enzyme induction and inhibition.
- Covers drug conjugation reactions (Phase 2).
- Discusses the effect of stereochemistry on metabolism.
- Provides metabolic pathways for common drugs, a tutorial example, and practice problems.
Chapter 6: Volumetric Analysis of Drugs
- The chapter begins by discussing volumetric analysis of drugs (the rest of the chapter content is not provided in the excerpt).
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Description
Explore the essentials of pharmaceutical chemistry with a focus on the chemistry of acids and bases, as well as partition coefficients and their biopharmaceutical relevance. Dive into key concepts like buffer solutions, drug ionization, and the importance of drug absorption and distribution. This quiz will enhance your understanding of important foundational topics in pharmaceutical science.
