17 Questions
What is the main genetic abnormality associated with sickle cell disease?
Abnormal synthesis of hemoglobin
How does sickled red blood cell (RBC) behavior differ from normal RBCs?
Sickled cells rupture easily and have a shorter lifespan
How do sickled cells contribute to organ damage in sickle cell disease?
They clump together, blocking blood flow and causing oxygen deprivation
Why do individuals with sickle cell disease often experience severe pain crises?
Due to the blockage of blood vessels by sickled cells
Which condition results in a deficiency of clotting factor VIII?
Hemophilia A
How does the gene responsible for sickling help in resisting malaria?
It allows potassium leakage which kills malaria parasites
What is the typical lifespan of sickled red blood cells?
~10-20 days
What is the main pathophysiological feature of sickle cell disease?
Clumping and blocking of blood vessels
What is the genetic abnormality associated with sickle cell disease?
Abnormal type of Hemoglobin (Hb-S)
How do sickled red blood cells contribute to severe anemia in sickle cell disease?
They rupture prematurely releasing damaging Hgb
What is the mechanism by which the gene responsible for sickling helps in resisting malaria?
Low levels of potassium inside cells
Which process results in the deprivation of organs with oxygen in sickle cell disease?
Clumping and blocking of blood vessels
What is the main feature that distinguishes sickled red blood cell behavior from normal RBCs?
Rupturing easily
Which factor is deficient in Hemophilia A (Classic Hemophilia)?
Clotting factor VIII
How do sickled red blood cells differ from normal RBCs in terms of movement through blood vessels?
They do not move easily through blood vessels
Which gene defect leads to the resistance to malaria seen in individuals with sickle cell disease?
"Sickling gene" defect
"Christmas Disease" is associated with a deficiency in which clotting factor?
(IX)
Test your knowledge on the cardiovascular system focusing on blood components like erythrocytes, leukocytes, platelets, and clotting. Explore the formation of blood cells, blood groups, and pathophysiology of various diseases related to blood.
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