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Pharma 121L: Cardiovascular System - Blood Contents Quiz

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Pharma 121L: Cardiovascular System - Blood Contents Quiz

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Questions and Answers

What is the main genetic abnormality associated with sickle cell disease?

Excessive release of leukocytes

Mutation in clotting factor genes

Abnormal synthesis of hemoglobin (correct)

Deficiency of clotting factor VIII

How does sickled red blood cell (RBC) behavior differ from normal RBCs?

Sickled cells rupture easily and have a shorter lifespan (correct)

Sickled cells have a longer lifespan and move easily through blood vessels

Normal RBCs release excessive potassium

Normal RBCs clump together and block blood flow

How do sickled cells contribute to organ damage in sickle cell disease?

They release excess hemoglobin, damaging the kidneys

They clump together, blocking blood flow and causing oxygen deprivation (correct)

They have an abnormal synthesis of white blood cells

They move too quickly through blood vessels, causing frictional damage

Why do individuals with sickle cell disease often experience severe pain crises?

Due to the blockage of blood vessels by sickled cells Signup and view all the answers

Which condition results in a deficiency of clotting factor VIII?

Hemophilia A Signup and view all the answers

How does the gene responsible for sickling help in resisting malaria?

It allows potassium leakage which kills malaria parasites Signup and view all the answers

What is the typical lifespan of sickled red blood cells?

~10-20 days Signup and view all the answers

What is the main pathophysiological feature of sickle cell disease?

Clumping and blocking of blood vessels Signup and view all the answers

What is the genetic abnormality associated with sickle cell disease?

Abnormal type of Hemoglobin (Hb-S) Signup and view all the answers

How do sickled red blood cells contribute to severe anemia in sickle cell disease?

They rupture prematurely releasing damaging Hgb Signup and view all the answers

What is the mechanism by which the gene responsible for sickling helps in resisting malaria?

Low levels of potassium inside cells Signup and view all the answers

Which process results in the deprivation of organs with oxygen in sickle cell disease?

Clumping and blocking of blood vessels Signup and view all the answers

What is the main feature that distinguishes sickled red blood cell behavior from normal RBCs?

Rupturing easily Signup and view all the answers

Which factor is deficient in Hemophilia A (Classic Hemophilia)?

Clotting factor VIII Signup and view all the answers

How do sickled red blood cells differ from normal RBCs in terms of movement through blood vessels?

They do not move easily through blood vessels Signup and view all the answers

Which gene defect leads to the resistance to malaria seen in individuals with sickle cell disease?

"Sickling gene" defect Signup and view all the answers

"Christmas Disease" is associated with a deficiency in which clotting factor?

(IX) Signup and view all the answers