Podcast
Questions and Answers
What is the main genetic abnormality associated with sickle cell disease?
What is the main genetic abnormality associated with sickle cell disease?
- Excessive release of leukocytes
- Mutation in clotting factor genes
- Abnormal synthesis of hemoglobin (correct)
- Deficiency of clotting factor VIII
How does sickled red blood cell (RBC) behavior differ from normal RBCs?
How does sickled red blood cell (RBC) behavior differ from normal RBCs?
- Sickled cells rupture easily and have a shorter lifespan (correct)
- Sickled cells have a longer lifespan and move easily through blood vessels
- Normal RBCs release excessive potassium
- Normal RBCs clump together and block blood flow
How do sickled cells contribute to organ damage in sickle cell disease?
How do sickled cells contribute to organ damage in sickle cell disease?
- They release excess hemoglobin, damaging the kidneys
- They clump together, blocking blood flow and causing oxygen deprivation (correct)
- They have an abnormal synthesis of white blood cells
- They move too quickly through blood vessels, causing frictional damage
Why do individuals with sickle cell disease often experience severe pain crises?
Why do individuals with sickle cell disease often experience severe pain crises?
Which condition results in a deficiency of clotting factor VIII?
Which condition results in a deficiency of clotting factor VIII?
How does the gene responsible for sickling help in resisting malaria?
How does the gene responsible for sickling help in resisting malaria?
What is the typical lifespan of sickled red blood cells?
What is the typical lifespan of sickled red blood cells?
What is the main pathophysiological feature of sickle cell disease?
What is the main pathophysiological feature of sickle cell disease?
What is the genetic abnormality associated with sickle cell disease?
What is the genetic abnormality associated with sickle cell disease?
How do sickled red blood cells contribute to severe anemia in sickle cell disease?
How do sickled red blood cells contribute to severe anemia in sickle cell disease?
What is the mechanism by which the gene responsible for sickling helps in resisting malaria?
What is the mechanism by which the gene responsible for sickling helps in resisting malaria?
Which process results in the deprivation of organs with oxygen in sickle cell disease?
Which process results in the deprivation of organs with oxygen in sickle cell disease?
What is the main feature that distinguishes sickled red blood cell behavior from normal RBCs?
What is the main feature that distinguishes sickled red blood cell behavior from normal RBCs?
Which factor is deficient in Hemophilia A (Classic Hemophilia)?
Which factor is deficient in Hemophilia A (Classic Hemophilia)?
How do sickled red blood cells differ from normal RBCs in terms of movement through blood vessels?
How do sickled red blood cells differ from normal RBCs in terms of movement through blood vessels?
Which gene defect leads to the resistance to malaria seen in individuals with sickle cell disease?
Which gene defect leads to the resistance to malaria seen in individuals with sickle cell disease?
"Christmas Disease" is associated with a deficiency in which clotting factor?
"Christmas Disease" is associated with a deficiency in which clotting factor?
