Questions and Answers
What is the therapeutic classification of Montelukast?
What is the primary indication for Montelukast?
Asthma prophylaxis and allergic rhinitis
In what year was Montelukast first approved?
1998
What is the mechanism of action of Montelukast?
Signup and view all the answers
Which of the following are common side effects of Montelukast?
Signup and view all the answers
Montelukast is contraindicated in patients with hypersensitivity to the drug.
Signup and view all the answers
What category is Montelukast for use during pregnancy?
Signup and view all the answers
What are the common symptoms of overdose for Montelukast?
Signup and view all the answers
Match the drugs similar to Montelukast with their names:
Signup and view all the answers
What is the primary route of administration for Montelukast?
Signup and view all the answers
How long does it take for Montelukast to have an onset of action?
Signup and view all the answers
Study Notes
Montelukast (Singulair) Overview
- Therapeutic classification: Drug for asthma prophylaxis and allergic rhinitis.
- Pharmacologic classification: Leukotriene modifier.
Therapeutic Effects and Uses
- Approved in 1998 for long-term control of asthma symptoms, not for acute attacks.
- Relieves symptoms associated with allergic and seasonal rhinitis.
- Pediatric formulation available as chewable tablets and oral granules for mixing with soft food.
- Approved in 2007 for prevention of exercise-induced bronchospasm when taken 2+ hours prior to activity; the only drug in this class with this indication.
Mechanism of Action
- Blocks leukotriene receptors in airways, preventing airway edema and inflammation.
Pharmacokinetics
- Administered orally (PO); rapidly absorbed.
- More than 99% bound to plasma protein; secreted in breast milk.
- Undergoes extensive hepatic metabolism through CYP2C9 and CYP3A4.
- Primarily excreted via bile; onset of action within 1 week, half-life up to 5.5 hours.
Adverse Effects
- Generally mild side effects; most common is headache.
- Other reported effects include rhinitis, influenza-like symptoms, and abdominal pain.
- Rare neuropsychiatric events: aggression, anxiety, depression, suicidal ideation, memory impairment.
Contraindications/Precautions
- Absolute contraindication: hypersensitivity to montelukast.
Drug Interactions
- Metabolized by CYP450 enzymes; risk of interaction with inhibitors such as carbamazepine, erythromycin, and azole antifungals.
- St. John's wort may decrease efficacy of montelukast.
Pregnancy Consideration
- Classified as Category B, indicating no known risks in humans.
Treatment of Overdose
- Symptoms: headache, abdominal pain, nausea, vomiting.
- Treatment includes supportive care.
Similar Drugs
- Roflumilast (Daliresp)
- Zafirlukast (Accolate)
- Zileuton (Zyflo CR)
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge on the prototype drug montelukast, commonly known as Singulair. This set of flashcards covers its classification, therapeutic effects, and uses as a treatment for asthma prophylaxis and allergic rhinitis. Perfect for pharmacology students preparing for their Pharm II exam.
