Pharm II Exam 2: Montelukast (Singulair) Flashcards
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Questions and Answers

What is the therapeutic classification of Montelukast?

  • Corticosteroid
  • Antihistamine
  • Bronchodilator
  • Leukotriene modifier (correct)
  • What is the primary indication for Montelukast?

    Asthma prophylaxis and allergic rhinitis

    In what year was Montelukast first approved?

    1998

    What is the mechanism of action of Montelukast?

    <p>Blocks leukotriene receptors</p> Signup and view all the answers

    Which of the following are common side effects of Montelukast?

    <p>Headache</p> Signup and view all the answers

    Montelukast is contraindicated in patients with hypersensitivity to the drug.

    <p>True</p> Signup and view all the answers

    What category is Montelukast for use during pregnancy?

    <p>Category B</p> Signup and view all the answers

    What are the common symptoms of overdose for Montelukast?

    <p>Headache, abdominal pain, nausea, vomiting</p> Signup and view all the answers

    Match the drugs similar to Montelukast with their names:

    <p>Roflumilast = Daliresp Zafirlukast = Accolate Zileuton = Zyflo CR</p> Signup and view all the answers

    What is the primary route of administration for Montelukast?

    <p>PO</p> Signup and view all the answers

    How long does it take for Montelukast to have an onset of action?

    <p>1 week</p> Signup and view all the answers

    Study Notes

    Montelukast (Singulair) Overview

    • Therapeutic classification: Drug for asthma prophylaxis and allergic rhinitis.
    • Pharmacologic classification: Leukotriene modifier.

    Therapeutic Effects and Uses

    • Approved in 1998 for long-term control of asthma symptoms, not for acute attacks.
    • Relieves symptoms associated with allergic and seasonal rhinitis.
    • Pediatric formulation available as chewable tablets and oral granules for mixing with soft food.
    • Approved in 2007 for prevention of exercise-induced bronchospasm when taken 2+ hours prior to activity; the only drug in this class with this indication.

    Mechanism of Action

    • Blocks leukotriene receptors in airways, preventing airway edema and inflammation.

    Pharmacokinetics

    • Administered orally (PO); rapidly absorbed.
    • More than 99% bound to plasma protein; secreted in breast milk.
    • Undergoes extensive hepatic metabolism through CYP2C9 and CYP3A4.
    • Primarily excreted via bile; onset of action within 1 week, half-life up to 5.5 hours.

    Adverse Effects

    • Generally mild side effects; most common is headache.
    • Other reported effects include rhinitis, influenza-like symptoms, and abdominal pain.
    • Rare neuropsychiatric events: aggression, anxiety, depression, suicidal ideation, memory impairment.

    Contraindications/Precautions

    • Absolute contraindication: hypersensitivity to montelukast.

    Drug Interactions

    • Metabolized by CYP450 enzymes; risk of interaction with inhibitors such as carbamazepine, erythromycin, and azole antifungals.
    • St. John's wort may decrease efficacy of montelukast.

    Pregnancy Consideration

    • Classified as Category B, indicating no known risks in humans.

    Treatment of Overdose

    • Symptoms: headache, abdominal pain, nausea, vomiting.
    • Treatment includes supportive care.

    Similar Drugs

    • Roflumilast (Daliresp)
    • Zafirlukast (Accolate)
    • Zileuton (Zyflo CR)

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    Description

    Test your knowledge on the prototype drug montelukast, commonly known as Singulair. This set of flashcards covers its classification, therapeutic effects, and uses as a treatment for asthma prophylaxis and allergic rhinitis. Perfect for pharmacology students preparing for their Pharm II exam.

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