Pharm II: Antibiotics and Warfarin Drug Interaction
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Questions and Answers

Which class of antibiotics inhibits cell wall synthesis?

  • Polymyxin
  • Aminoglycosides
  • Sulfonamides (correct)
  • Macrolides

What is the mechanism of action of vancomycin?

  • Affecting protein synthesis
  • Affecting DNA synthesis
  • Inhibiting cell wall synthesis (correct)
  • Affecting cytoplasmic membrane

Which antibiotic may have both bactericidal and bacteriostatic activity depending on the dose or specific bacteria?

  • Trimethoprim
  • Fluoroquinolones
  • Tetracyclines (correct)
  • Chloramphenicol

What is a common mechanism of resistance to antibiotics?

<p>Misuse and overuse of antibiotics (D)</p> Signup and view all the answers

Which of the following is a possible hypothesis for the interaction between oral contraceptives (OCs) and antibiotics?

<p>Increased enterohepatic circulation (A)</p> Signup and view all the answers

Which category of antibacterial drugs is associated with a 13 fold increase in the risk of unintended pregnancies when taken with oral contraceptives?

<p>Rifampicin (B)</p> Signup and view all the answers

Which organization does not advise any additional precautions despite the uncertainties regarding the interaction between antibiotics and oral contraceptives?

<p>World Health Organization (WHO) (A)</p> Signup and view all the answers

Which enzyme-inducing drug is mentioned in the text as posing a risk of unintended pregnancies when taken with oral contraceptives?

<p>Carbamazepine (A)</p> Signup and view all the answers

What is a potential mechanism by which fluoroquinolones increase the effect of warfarin?

<p>Inhibition of warfarin metabolism (A)</p> Signup and view all the answers

How do macrolides such as azithromycin and erythromycin affect the metabolism of warfarin?

<p>They inhibit hepatic metabolism of warfarin (A)</p> Signup and view all the answers

What is a consideration for penicillins in relation to warfarin use?

<p>They displace warfarin from protein binding sites (C)</p> Signup and view all the answers

What is a potential effect of sulfonamides on warfarin therapy?

<p>Altered gut flora affecting vitamin K synthesis (B)</p> Signup and view all the answers

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