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Pharm Focused Review: Dementia and Alzheimer's Disease

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30 Questions

Muscle stiffness, tremors, restlessness, and involuntary movements are common side effects of which medication?

Antipsychotic agents

Which antipsychotic medication should be used with caution in patients with Parkinson's disease?

Risperidone

Which symptom indicates a potential need for antipsychotic treatment according to the text?

Restlessness and inability to sit still

What is a common response time to antidepressants in patients with anxiety and depression, according to the text?

4-6 weeks

Which Alzheimer's medication is less prone to drug interactions and cholinergic side effects?

Rivastigmine

What is a typical goal in managing Alzheimer's disease, according to the text?

Delaying the need for nursing home

Which system metabolizes tacrine, donepezil, and galantamine, potentially leading to drug interactions?

P450 enzyme system

Which type of behavior is a core symptom of schizophrenia?

Hyperactive movements

Which antipsychotic class carries a higher risk of extrapyramidal symptoms compared to newer atypical antipsychotics?

Haloperidol

What is a potential side effect of antipsychotic medications in terms of metabolic changes?

High blood sugar levels

What is the main characteristic of neurofibrillary tangles in Alzheimer Disease?

Hyperphosphorylated Tau proteins

Which of the following is NOT a reversible cause of dementia?

Apolipoprotein E

What is the primary mechanism of cholinesterase inhibitors in treating Alzheimer Disease?

Increased levels of acetylcholine

Which of the following is a side effect of rivastigmine?

Headache

What is the expected response time to cholinesterase inhibitors in Alzheimer Disease?

Within 3-6 months

What is the primary reason for switching to another cholinesterase inhibitor in Alzheimer Disease?

Lack of response within 3-6 months

What is the primary cognitive deficit in Alzheimer Disease?

Slow, progressive decline in cognition

Which of the following is a risk factor for Alzheimer Disease?

All of the above

What is the effect of excessive glutamate stimulation in Alzheimer Disease?

Neuronal toxicity

What is the primary benefit of galantamine in Alzheimer Disease?

Improved cognitive function

Which antipsychotic medication should be avoided in patients with a prolonged QT interval?

Fluphenazine

Which antipsychotic carries the least risk of metabolic syndrome?

Lurasidone

Which antipsychotic should be considered for patients with Parkinson disease–related psychosis?

Pimavanserin

Which benzodiazepine is particularly associated with risk for addiction and tolerance?

Alprazolam

Which antipsychotic medication is commonly used in its injectable form for poor compliance or high risk of relapse?

Fluphenazine

What is considered the drug of choice for patients with a history of prescription medication, alcohol, or substance abuse who may become dependent?

Buspirone

Which Alzheimer's medication is not primarily used for memory problems in dementia but rather for anxiety or episodic agitation?

Benzodiazepines

What should be avoided when taking benzodiazepines to prevent exacerbation of existing depression?

Alcohol

Which benzodiazepine carries risks of abuse, misuse, and addiction, potentially leading to overdose or death?

Temazepam

What is the most common side effect associated with benzodiazepines?

Drowsiness

This quiz covers topics related to dementia, neurocognitive disorders, formation of neurofibrillary tangles and plaques, cortical atrophy, and Alzheimer's Disease. It includes information about the causes of dementia such as genetic factors and traumatic brain injury.

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