Pharm Focused Review: Dementia and Alzheimer Disease
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Questions and Answers

What is the main pathological feature in Alzheimer Disease?

  • Presence of hyperphosphorylated Amyloid plaques
  • Cortical hypertrophy and increased neuronal activity
  • Presence of neurosyphilis and toxoplasmosis
  • Formation of neurofibrillary tangles with hyperphosphorylated Tau proteins (correct)

    • What is considered a reversible cause of dementia?

  • Thyroid disorders (correct)
  • Presence of neurofibrillary tangles
  • Chronic exposure to lead and mercury
  • Elevated cholinesterase levels

    • Which neurotransmitter is decreased in Alzheimer Disease and leads to excessive stimulation of glutamate?

  • GABA
  • Acetylcholine (correct)
  • Serotonin
  • Dopamine

    • What is the initial treatment choice for mild to moderate Alzheimer Disease?

    <p>Cholinesterase inhibitors</p> Signup and view all the answers

    Which medication may be considered if there is no response to cholinesterase inhibitors within 3-6 months?

    <p>Another cholinesterase inhibitor</p> Signup and view all the answers

    What symptom is NOT associated with antipsychotic medication?

    <p>Confusion</p> Signup and view all the answers

    Which of the following is NOT a side effect of Memantine (Namenda)?

    <p>Respiratory depression</p> Signup and view all the answers

    Why is rivastigmine considered to have an advantage over other cholinesterase inhibitors?

    <p>It is not metabolized by the P450 enzyme system</p> Signup and view all the answers

    Which symptom is characteristic of akathisia in patients receiving antipsychotic medication?

    <p>Restlessness</p> Signup and view all the answers

    What is a key consideration for using risperidone in patients with Parkinson's disease?

    <p>Higher risk of extrapyramidal symptoms</p> Signup and view all the answers

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