Questions and Answers
What is the drug classification of Perphenazine (Trilafon)?
What are the indications for Perphenazine (Trilafon)?
Schizophrenia, bipolar disorder, treatment of intractable hiccups
One of the side effects of Perphenazine (Trilafon) includes _____.
neuroleptic malignant syndrome
Which of the following side effects are associated with Perphenazine (Trilafon)?
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What are the nursing responsibilities when administering Perphenazine (Trilafon)?
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What actions does Perphenazine (Trilafon) have in the CNS?
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Which condition is Perphenazine (Trilafon) contraindicated for?
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Who should be cautioned when prescribing Perphenazine (Trilafon)?
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Study Notes
Perphenazine (Trilafon) Overview
- Classification: Antipsychotic, specifically a phenothiazine
- Pregnancy Category: C
- Routes of administration: Oral (PO), Intramuscular (IM), Intravenous (IV)
- High liver and gastrointestinal mucosa metabolism
- Protein binding exceeds 90%
- Half-life: 8.4 to 12.3 hours
Indications for Use
- Primarily used for schizophrenia
- Effective in managing bipolar disorder
- Treatment option for intractable hiccups
Side Effects
- Risk of neuroleptic malignant syndrome and agranulocytosis
- Possible extrapyramidal reactions and sedation
- Other effects include blurred vision, dry eyes, and lens opacities
- May cause hypotension, increased heart rate, constipation, dry mouth, and anorexia
- Associated with weight gain and discoloration of urine
- Can lead to urinary retention, photosensitivity, and skin rashes
- Hormonal side effects include galactorrhea and amenorrhea
- Potential for leukopenia, hyperthermia, and severe allergic reactions
Nursing Responsibilities
- Use caution when prescribing for elderly patients
- Not indicated for pediatric populations
- Monitor complete blood count (CBC) and liver function tests (LFT)
- Regular eye examinations and assessment for neuroleptic malignant syndrome (NMS), tardive dyskinesia (TD), and extrapyramidal symptoms (EPS)
- Track weight, body mass index (BMI), fasting blood sugar (FBS), and lipid levels
- Be mindful of additive effects with alcohol, sedatives, and antihistamines
Mechanism of Action
- Alters dopamine effects within the central nervous system (CNS)
- Exerts anticholinergic and antihistamine effects
- Functions as an alpha-adrenergic blocker
- Blocks dopamine in the chemoreceptor trigger zone, aiding in reducing nausea
Contraindications
- Hypersensitivity to perphenazine or bisulfites
- Contraindicated in patients with alcohol intolerance and angle closure glaucoma
- Not suitable for individuals with pre-existing bone marrow depression or blood dyscrasias
- Avoid in cases of severe liver or cardiovascular disease and intestinal obstruction
Precautions
- Use with caution in geriatrics, emaciated or debilitated clients
- Special care needed for patients with diabetes, respiratory depression, prostatic hyperplasia, CNS tumors, or a history of seizure disorders
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Description
Test your knowledge on Perphenazine (Trilafon) with these flashcards. This quiz covers drug classification, indications, and potential side effects. Perfect for students in pharmacology or nursing programs!
