Module 4 PP. Perioperative Crystalloids Quiz
58 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary purpose of hypotonic crystalloids?

  • To replace electrolyte losses in a patient who has been fasting
  • To increase the effective osmolality of the extracellular fluid (ECF)
  • To draw water into the intracellular compartment (correct)
  • To treat a patient with a low sodium concentration
  • Which of the following solutions is an example of a hypertonic crystalloid?

  • Plasma-Lyte 56 (5% dex)
  • 0.45% NaCl
  • Dextrose 5% in NS (correct)
  • 5% Dextrose in water
  • What is the effect of hypertonic crystalloids on the intracellular compartment?

  • Water is drawn out of the intracellular compartment. (correct)
  • Water is drawn into the intracellular compartment.
  • No change in water distribution occurs.
  • The intracellular compartment becomes hypertonic.
  • Besides replacing water and electrolyte losses in fasting patients, what other potential uses do perioperative crystalloids have?

    <p>Minimizing preoperative fasting time (B)</p> Signup and view all the answers

    What is the goal of fluid administration during surgery, according to the American Society of Anesthesiologists (ASA)?

    <p>A moderately liberal overall positive fluid balance (A)</p> Signup and view all the answers

    Why is minimizing preoperative fasting time an important consideration with perioperative crystalloid administration?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary purpose of hemodynamic monitoring in the context of perioperative crystalloid administration?

    <p>To guide fluid volume resuscitation (D)</p> Signup and view all the answers

    What is the primary difference between hypotonic and hypertonic crystalloids?

    <p>Their effect on the intracellular fluid compartment (A)</p> Signup and view all the answers

    Which of the following is NOT an example of an isotonic crystalloid solution?

    <p>D5W (C)</p> Signup and view all the answers

    What is the approximate normal value for Strong Ion Difference (SID) in plasma?

    <p>40 mEq/L (A)</p> Signup and view all the answers

    Which of the following contributes to the strong ion difference (SID)?

    <p>All of the above (D)</p> Signup and view all the answers

    How does an increase in Strong Ion Difference (SID) affect pH?

    <p>It increases pH (B)</p> Signup and view all the answers

    What condition is associated with a decrease in Strong Ion Difference (SID) due to an excessive infusion of 0.9% NaCl?

    <p>Hyperchloremic metabolic acidosis (C)</p> Signup and view all the answers

    What is the primary reason why isotonic crystalloids are used to treat ECF deficits?

    <p>They contain similar electrolyte concentrations as the extracellular fluid, helping to restore balance (C)</p> Signup and view all the answers

    What is the approximate percentage of infused isotonic crystalloid volume that remains intravascular in healthy patients after 30 minutes?

    <p>25% (A)</p> Signup and view all the answers

    How does surgery and anesthesia influence the distribution of isotonic crystalloids?

    <p>They increase the volume of distribution (C)</p> Signup and view all the answers

    What is magnesium primarily used to treat?

    <p>Hypomagnesemia (A)</p> Signup and view all the answers

    Which of the following is NOT a patient factor that increases the risk of hypervolemia during surgery?

    <p>Hypothyroidism (A), History of previous surgeries (B)</p> Signup and view all the answers

    Identify the potential risks associated with fluid overload during surgery:

    <p>All of the above (E)</p> Signup and view all the answers

    Which of the listed factors contributes to decreased venous return during surgery?

    <p>Positive pressure mechanical ventilation (A)</p> Signup and view all the answers

    Which of the following is NOT a consequence of hypervolemia during surgery?

    <p>Improved tissue perfusion (B)</p> Signup and view all the answers

    Which of the following is a potential benefit of goal-directed fluid therapy?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is true regarding goal-directed fluid therapy?

    <p>It involves using dynamic parameters to guide fluid administration, like hemodynamic monitoring. (E)</p> Signup and view all the answers

    Which of the following contributes to hypervolemia during general anesthesia?

    <p>C and D, but not A and B. (E)</p> Signup and view all the answers

    Which of the following is NOT a common electrolyte found in Normosol and Plasma-Lyte?

    <p>Calcium (D)</p> Signup and view all the answers

    What is the primary dietary source from which iron is absorbed?

    <p>Small intestine (A)</p> Signup and view all the answers

    Which condition is NOT a common cause of iron deficiency anemia?

    <p>Excessive iron supplementation (C)</p> Signup and view all the answers

    What is the effect of vitamin C on iron absorption?

    <p>Increases absorption (B)</p> Signup and view all the answers

    Which of the following best describes agglutinogen?

    <p>An antigen that triggers antibody formation (A)</p> Signup and view all the answers

    What happens to red blood cells as they age beyond 14 to 21 days?

    <p>They undergo biochemical changes leading to fragility (D)</p> Signup and view all the answers

    What is the minimum acceptable hemoglobin level for a patient receiving a blood transfusion?

    <p>Patient-specific (B)</p> Signup and view all the answers

    Which factor does NOT influence the need for blood transfusion?

    <p>Patient's preference (B)</p> Signup and view all the answers

    What is the risk associated with blood transfusions after 14 days?

    <p>Risk of transfusion-related acute lung injury (C)</p> Signup and view all the answers

    What is the consequence of hemoglobin synthesis mobilizing tissue iron stores?

    <p>Increased availability of iron for erythropoiesis (B)</p> Signup and view all the answers

    What is a common consequence of sickle cell disease?

    <p>Hemolysis and destruction of red blood cells (C)</p> Signup and view all the answers

    What is the goal for platelet (PLT) replacement therapy?

    <blockquote> <p>150,000 (C)</p> </blockquote> Signup and view all the answers

    What is the recommended volume for one unit of pRBCs?

    <p>~325 ml (B)</p> Signup and view all the answers

    Which of the following is a critical role of red blood cells (RBCs) in hemostasis?

    <p>Releasing ADP to activate platelets (B)</p> Signup and view all the answers

    What is the target hemoglobin (Hgb) level in coagulopathy management?

    <blockquote> <p>8 g/dL (B)</p> </blockquote> Signup and view all the answers

    What is the primary risk associated with aggressive crystalloid resuscitation in severe trauma?

    <p>Dilutional coagulopathy (C)</p> Signup and view all the answers

    Which component is crucial in management for a patient experiencing postpartum hemorrhage (PPH)?

    <p>Fibrinogen maintenance (B)</p> Signup and view all the answers

    What is the typical use of antifibrinolytic agents in clinical scenarios?

    <p>Preserving clot formation (C)</p> Signup and view all the answers

    What is the recommended ratio of blood components for trauma-associated coagulopathy management?

    <p>1:1:1 (C)</p> Signup and view all the answers

    What is the primary effect of citrate toxicity during blood transfusion?

    <p>Depletes serum free calcium (B)</p> Signup and view all the answers

    What is a common potential cause of postpartum hemorrhage (PPH)?

    <p>Uterine atony (A)</p> Signup and view all the answers

    What is the preferred type of IV access for blood transfusions to reduce complications?

    <p>Dedicated line or large-bore PIV (C)</p> Signup and view all the answers

    What is the purpose of using filters in blood transfusions?

    <p>To remove clots and aggregates (B)</p> Signup and view all the answers

    Which statement regarding red blood cell (RBC) storage is true?

    <p>RBCs are kept cold until the decision to transfuse. (B)</p> Signup and view all the answers

    What is the preferred fluid for dilution when administering blood products?

    <p>Normal saline or isotonic crystalloids (C)</p> Signup and view all the answers

    What is the primary indication for using fresh frozen plasma (FFP)?

    <p>To treat or prevent bleeding by replacing volume and coagulation factors (D)</p> Signup and view all the answers

    Cryoprecipitate is rich in which factor crucial for hemostasis?

    <p>Fibrinogen (Factor I) (D)</p> Signup and view all the answers

    What needs to be monitored to avoid thrombus formation during platelet transfusions?

    <p>PLT count (D)</p> Signup and view all the answers

    What adverse effect is associated with transfusion-transmissible infections?

    <p>Immunosuppression (D)</p> Signup and view all the answers

    Which condition is characterized by acute lung injury within 6 hours of transfusion?

    <p>Transfusion-related acute lung injury (TRALI) (D)</p> Signup and view all the answers

    What is a critical factor influencing Graft versus Host Disease (GVHD) after platelet transfusions?

    <p>Presence of viable white blood cells (D)</p> Signup and view all the answers

    How much does one unit of platelets increase the count per microL?

    <p>20,000 – 50,000/microL (C)</p> Signup and view all the answers

    What is the minimum acceptable platelet count for surgical patients?

    <p>50,000 – 100,000/microL (C)</p> Signup and view all the answers

    What clinical indication warrants the administration of plasma?

    <p>Volume replacement for hemorrhagic shock (D)</p> Signup and view all the answers

    Flashcards

    Bleeding

    Loss of blood that can lead to coagulopathy and shock.

    Coagulopathy

    A blood disorder affecting coagulation, often due to factors like hemodilution.

    Hypervolemia

    Excessive fluid volume in the body, risking reduced tissue perfusion.

    Goal-Directed Fluid Therapy

    Fluid administration aimed at achieving specific hemodynamic goals.

    Signup and view all the flashcards

    Tissue Edema

    Swelling due to excess fluid in tissues, often caused by hypervolemia.

    Signup and view all the flashcards

    Cardiac Output

    The amount of blood the heart pumps, critical for tissue perfusion.

    Signup and view all the flashcards

    EVAPORATIVE losses

    Fluid losses through evaporation, often unnoticed during extended surgeries.

    Signup and view all the flashcards

    Intravenous Fluid Therapy

    Delivering fluids via a vein to maintain hydration and blood pressure.

    Signup and view all the flashcards

    Hypotonic Crystalloids

    IV fluids with lower effective osmolality than blood, causing water to enter cells.

    Signup and view all the flashcards

    Use of Hypotonic Crystalloids

    Administered for maintenance, treating water deficits, or drug delivery.

    Signup and view all the flashcards

    Examples of Hypotonic Crystalloids

    0.45% NaCl, 5% Dextrose in water, Plasma-Lyte 56.

    Signup and view all the flashcards

    Hypertonic Crystalloids

    IV fluids with greater effective osmolality than blood, causing water to leave cells.

    Signup and view all the flashcards

    Use of Hypertonic Crystalloids

    Used to increase solute concentration or promote fluid movement.

    Signup and view all the flashcards

    Examples of Hypertonic Crystalloids

    Dextrose 5% in NS, 3-7.5% Saline.

    Signup and view all the flashcards

    Perioperative Crystalloid Administration

    Fluid replacement in fasting patients during surgery.

    Signup and view all the flashcards

    Fluid Balance Goal

    Achieve an overall positive fluid balance by end of surgery.

    Signup and view all the flashcards

    Dietary Deficiency Anemia

    Anemia caused by a lack of essential nutrients like iron, folic acid, and vitamin B12.

    Signup and view all the flashcards

    Iron Absorption

    Iron is absorbed from the diet in the small intestine and its absorption is enhanced by vitamin C.

    Signup and view all the flashcards

    Iron Storage in Erythrocytes

    About 80% of absorbed iron goes into bone marrow to form new red blood cells.

    Signup and view all the flashcards

    Iron Deficiency Causes

    Iron deficiency can occur due to inadequate intake, increased requirements, or absorption issues.

    Signup and view all the flashcards

    Agglutination

    A process where antibodies bind to antigens causing particles to clump together in blood transfusions.

    Signup and view all the flashcards

    RBC Aging Changes

    As red blood cells age, biochemical changes occur that can impair circulation and increase transfusion risks.

    Signup and view all the flashcards

    RBC Transfusion Guidelines

    Transfusion decisions depend on patient-specific hemoglobin levels and the need for increased oxygen carrying capacity.

    Signup and view all the flashcards

    Rh Factor

    An antigen that can cause an agglutination reaction when Rh-negative individuals are exposed to Rh-positive blood.

    Signup and view all the flashcards

    Iron Supplementation Effects

    Iron supplements can rapidly increase erythrocyte production and hemoglobin concentration within days.

    Signup and view all the flashcards

    Kidney Disease Anemia

    Anemia resulting from kidney issues that affect erythropoietin production, essential for red blood cell formation.

    Signup and view all the flashcards

    Serum Mg2+ Levels

    Serum magnesium below 1.2 mg/dL can cause major side effects, as magnesium stabilizes membranes.

    Signup and view all the flashcards

    Crystalloids

    Fluid solutions that contain water-soluble electrolytes and have low molecular weight molecules but lack proteins.

    Signup and view all the flashcards

    Tonicity

    Classifies fluids by their osmolality—isotonic, hypertonic, or hypotonic effect on cell water movement.

    Signup and view all the flashcards

    Isotonic Solutions

    Solutions with the same osmolality as plasma, which do not change cell volume.

    Signup and view all the flashcards

    Hypertonic Solutions

    Solutions with greater osmolality than plasma, causing cells to lose water.

    Signup and view all the flashcards

    Hypotonic Solutions

    Solutions with lower osmolality than plasma, causing cells to swell.

    Signup and view all the flashcards

    Strong Ion Difference (SID)

    The difference between completely dissociated cations and anions in plasma, affecting pH levels.

    Signup and view all the flashcards

    Effective SID

    Considers bicarb and albumin phosphates in addition to regular SID.

    Signup and view all the flashcards

    Volume Kinetics of Isotonic Crystalloids

    The distribution of isotonic crystalloids is influenced by factors like dehydration and surgical status.

    Signup and view all the flashcards

    Intravenous Fluid Use

    Isotonic crystalloids are used to treat ECF deficits and administer various medications.

    Signup and view all the flashcards

    IV Access

    Adequate intravenous access is essential for blood transfusion; a large-bore PIV is preferred.

    Signup and view all the flashcards

    Transfusion Filters

    Used in blood transfusion to remove clots and aggregates; usually 170-260 micron filters are employed.

    Signup and view all the flashcards

    RBC Storage

    Red blood cells (RBC) must be kept cold until transfusion and can be warmed if previously thawed to avoid hypothermia.

    Signup and view all the flashcards

    Compatible Fluids

    Fluids like NS, plasma, or albumin are recommended for diluting blood during transfusion.

    Signup and view all the flashcards

    Fresh Frozen Plasma (FFP)

    Plasma frozen within 8-24 hours of collection; can be used interchangeably with thawed plasma.

    Signup and view all the flashcards

    Plasma Indications

    Used to replace volume & factors in massive transfusions or treat bleeding.

    Signup and view all the flashcards

    Cryoprecipitate

    A derived product from thawed plasma rich in fibrinogen, factor VIII, and XIII; helps restore coagulation.

    Signup and view all the flashcards

    Platelet Lifespan

    Platelets have an average lifespan of 8-12 days and are vital for hemostasis.

    Signup and view all the flashcards

    Platelet Administration

    Each dose increases platelet count; administered to prevent bleeding in surgical patients.

    Signup and view all the flashcards

    TRALI

    Transfusion-Related Acute Lung Injury develops within 6 hours post-transfusion, symptoms include pulmonary edema.

    Signup and view all the flashcards

    Graft vs Host Disease

    Occurs when donated immune cells attack recipient's body; a concern in immunocompromised patients.

    Signup and view all the flashcards

    Transfusion Overload (TACO)

    Volume overload from transfusion can lead to heart failure symptoms like dyspnea and tachycardia.

    Signup and view all the flashcards

    Minimum PLT Count

    In surgical patients, a minimum platelet count of 50,000 – 100,000/microL is usually required.

    Signup and view all the flashcards

    Cryoprecipitate Administration

    Administer 1 unit of cryoprecipitate per 10 kg weight to restore fibrinogen levels.

    Signup and view all the flashcards

    Leukoreduction

    The process of removing white blood cells from blood products to minimize reactions and risks.

    Signup and view all the flashcards

    1:1:1 Ratio

    Transfusion goal of 1 unit frozen plasma, thawed plasma, or platelet for every unit of packed RBCs.

    Signup and view all the flashcards

    Coagulopathy Management

    Aim to correct clotting factor deficiencies with specific goals for PT, aPTT, and fibrinogen levels.

    Signup and view all the flashcards

    Antifibrinolytic agents

    Medications that prevent the breakdown of clots during surgery or trauma.

    Signup and view all the flashcards

    Dilutional coagulopathy

    Condition where clotting ability is reduced due to large fluid resuscitation diluting blood components.

    Signup and view all the flashcards

    Massive Transfusion for Trauma

    Use of 1:1:1 ratio blood products to manage severe hemorrhage in trauma cases.

    Signup and view all the flashcards

    Postpartum Hemorrhage (PPH)

    Excessive bleeding after childbirth, defined as >500 ml vaginal or >1000 ml C-section.

    Signup and view all the flashcards

    Tranexamic acid

    Antifibrinolytic agent used in PPH to help reduce bleeding.

    Signup and view all the flashcards

    RBCs in Hemostasis

    Red blood cells play a critical role in maintaining hemostasis by releasing ADP to activate platelets.

    Signup and view all the flashcards

    Hypocalcemia in Transfusions

    Condition caused by citrate toxicity from blood products that can lower calcium levels, risking arrhythmias.

    Signup and view all the flashcards

    Study Notes

    Electrolytes and Minerals

    • Sodium is primarily found in the extracellular fluid (ECF)
    • Normal levels range from 135-145 mEq/L
    • Functions include water balance, osmotic pressure control, nerve impulse conduction, and muscle contraction

    Sodium Alterations

    • Sodium intake comes from diet and intravenous fluids

    • Homeostasis is maintained by the kidneys, reabsorbing most filtered sodium

    • Hormones like RAAS, ADH, and SNS regulate BP and intravascular volume

    • Parathyroid hormone and natriuretic peptides stimulate sodium excretion

    • Hyponatremia:

      • Can be caused by hypervolemia (e.g., CHF, cirrhosis) or hypovolemia (e.g., diarrhea, vomiting)
      • Other causes include salt wasting or euvolemia (e.g., adrenal insufficiency, polydipsia)
      • Symptoms include nausea, vomiting, muscle cramps
      • Treatment depends on the underlying cause
    • Hypernatremia:

      • Caused by water loss (e.g., fever, sweating, osmotic diuresis)
      • Other causes include nephrogenic or central diabetes insipidus, or excessive sodium administration.
      • Symptoms may include dehydration signs, altered mental status, seizures, or coma
      • Treatment depends on the underlying cause

    Potassium

    • Primarily found intracellularly (98%)
    • Normal levels range from 3.5-5.2 mEq/L
    • Functions include cell membrane excitability (nerves, muscles, heart), kidney function, and influences osmotic pressure
    • Affects endothelial-dependent vasodilation, thrombus formation, and platelet activation

    Potassium Alterations

    • Hypokalemia:
      • Can be caused by diuretics, beta agonists, insulin, antibiotics, catecholamines
      • Also results from GI losses (e.g., laxatives, bowel prep)
      • Symptoms include muscle weakness, muscle cramps, rhabdomyolysis, ileus, nausea, vomiting, and dysrhythmias
        • These include T wave inversion, U waves, tachyarrhythmias (torsades, AFib)
    • Hyperkalemia:
      • Caused by potassium redistribution or inhibition of secretion (e.g., medications like SCh, digitalis), aldosterone antagonists, beta antagonists, NSAIDs, chemotherapy, and PRBC transfusion.
      • Symptoms include paresthesias, muscle weakness, widened QRS complexes, prolonged PR intervals, and cardiac conduction blockade leading to VF and asystole

    Magnesium

    • Primarily intracellular (bone, muscle, soft tissues)
    • Normal levels range from 1.7-2.4 mg/dL
    • Functions include protein synthesis, nucleic acid stability, neuromuscular function, muscle relaxation, antiarrhythmic effects, vasodilation, stabilization of the BBB, and reducing anesthetic requirements

    Magnesium Alterations

    • Hypomagnesemia:
      • Caused by dietary deficiency, GI malabsorption (e.g., alcoholism, vomiting, laxatives), and renal losses (e.g., diuretics, nephropathy)
      • Symptoms include prolonged PR and QT intervals, diminished T waves, torsades, arrhythmias, weakness, tetany, fasciculations, convulsions, nausea, and vomiting
    • Hypermagnesemia:
      • Caused by excessive magnesium administration
      • Symptoms include widened QRS complexes, conduction blockade, asystole, hypotension, respiratory depression, muscle paralysis, diminished reflexes, and narcosis

    Calcium

    • Predominantly stored in the skeleton
    • Normal levels range from 8.5-10.5 mg/dL
    • Functions include musculoskeletal strength, neuromuscular transmission, cardiac muscle contractility, relaxation, and rhythm; vascular motor tone, and intracellular signaling
    • Homeostasis is maintained by endocrine control through vitamin D, parathyroid hormone, and calcitonin; regulating intestinal absorption, renal reabsorption, and bone turnover

    Calcium Alterations

    • Hypocalcemia:
      • Can be caused by decreased albumin, vitamin D deficiency, or disorders like hypoparathyroidism, pancreatitis, chronic renal failure, and citrate binding during transfusions.
      • Symptoms include neuromuscular issues such as twitching, spasms, paresthesias, tetany, seizures, and dysrhythmias
    • Hypercalcemia:
      • Caused by disorders like hyperparathyroidism, or parathyroid adenoma
      • Additional causes include malignancies, excessive dietary supplementation, or medication-induced issues (e.g., diuretics, lithium)
      • Symptoms include GI smooth muscle relaxation (nausea, vomiting, constipation), decreased neuromuscular transmission (lethargy, hypotonia), polyuria, dehydration, renal stones, and shortened QT intervals

    Phosphate

    • Primarily intracellular (bone, soft tissue)
    • Normal level range 3-4.5 mg/dL
    • Functions include energy metabolism, intracellular signaling (cAMP), immune system regulation, coagulation cascade regulation, and acid-base balance

    Fluid Compartments

    • Body fluid is primarily composed of intracellular (2/3) and extracellular fluid (1/3)
    • Extracellular fluid is primarily interstitial (~80%) and plasma (~20%)

    Plasma Composition

    • Primarily water (90%)
    • Contains proteins (albumin, globulins) with roles in oncotic pressure, transport, pH, and coagulation
    • Electrolytes and small molecules like salts, nutrients, waste products, hormones, and blood cells are in <1% concentration

    Compartmental Fluid Movement

    • Small ions readily move between plasma and interstitial fluid
    • Larger molecules are prevented from free movement by tight junctions of endothelial cells and the endothelial glycocalyx layer

    Monitoring Intravascular Volume Status

    • Static parameters: Blood pressure, heart rate, urine output, mixed venous oxygen saturation are assessed but may lack sensitivity for identifying fluid imbalances
    • Dynamic parameters: Respiratory variations in arterial waveform, end-expiratory occlusion test, ultrasound technologies (esophageal doppler, echocardiography) are helpful to assess fluid responsiveness but can have limitations in specific conditions

    Crystalloids

    • Crystalloid solutions contain soluble electrolytes and small molecules
    • Classified by tonicity: Isotonic (e.g., 0.9% NaCl, Lactated Ringers), Hypotonic (e.g., 0.45% NaCl), Hypertonic (e.g., Dextrose 5% in NS)
    • Isotonic solutions contain electrolytes similar to extracellular fluid and remain in the blood vessels

    Colloids

    • Colloids contain large molecules
    • Examples: Albumin, Hydroxyethyl Starches (HES)
    • Used for expansion of intravascular volume

    Blood Physiology and Blood Transfusion

    • Red blood cells: Essential for oxygen transport
    • White blood cells: Part of the immune system
    • Platelets: Crucial for hemostasis

    Anemia and Iron Deficiency

    • Anemia is a reduced RBC/hemoglobin count
    • Iron deficiency is a possible cause of anemia

    Transfusion-Associated Complications

    • TACO: Transfusion-associated circulatory overload
    • TRALI: Transfusion-related acute lung injury
    • Citrate toxicity: Risk from citrate use in stored blood
    • Agglutination: Antibodies in recipient reacting with antigens on donor blood

    Massive Transfusion

    • Associated with life-threatening, uncontrolled bleeding
    • Severe complications including coagulopathy and hypothermia

    Coagulopathy Management

    • Aims to correct coagulation abnormalities that arise through interventions including transfusion or other treatments

    Studying That Suits You

    Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

    Quiz Team

    Related Documents

    Description

    Test your knowledge on the use of crystalloids in a perioperative setting. This quiz covers the differences between hypotonic, hypertonic, and isotonic solutions, their effects on hemodynamic monitoring, and guidelines for fluid administration during surgery. Challenge yourself to understand the complexities of fluid management.

    More Like This

    Use Quizgecko on...
    Browser
    Browser