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Questions and Answers
What is the primary purpose of hypotonic crystalloids?
What is the primary purpose of hypotonic crystalloids?
Which of the following solutions is an example of a hypertonic crystalloid?
Which of the following solutions is an example of a hypertonic crystalloid?
What is the effect of hypertonic crystalloids on the intracellular compartment?
What is the effect of hypertonic crystalloids on the intracellular compartment?
Besides replacing water and electrolyte losses in fasting patients, what other potential uses do perioperative crystalloids have?
Besides replacing water and electrolyte losses in fasting patients, what other potential uses do perioperative crystalloids have?
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What is the goal of fluid administration during surgery, according to the American Society of Anesthesiologists (ASA)?
What is the goal of fluid administration during surgery, according to the American Society of Anesthesiologists (ASA)?
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Why is minimizing preoperative fasting time an important consideration with perioperative crystalloid administration?
Why is minimizing preoperative fasting time an important consideration with perioperative crystalloid administration?
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What is the primary purpose of hemodynamic monitoring in the context of perioperative crystalloid administration?
What is the primary purpose of hemodynamic monitoring in the context of perioperative crystalloid administration?
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What is the primary difference between hypotonic and hypertonic crystalloids?
What is the primary difference between hypotonic and hypertonic crystalloids?
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Which of the following is NOT an example of an isotonic crystalloid solution?
Which of the following is NOT an example of an isotonic crystalloid solution?
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What is the approximate normal value for Strong Ion Difference (SID) in plasma?
What is the approximate normal value for Strong Ion Difference (SID) in plasma?
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Which of the following contributes to the strong ion difference (SID)?
Which of the following contributes to the strong ion difference (SID)?
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How does an increase in Strong Ion Difference (SID) affect pH?
How does an increase in Strong Ion Difference (SID) affect pH?
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What condition is associated with a decrease in Strong Ion Difference (SID) due to an excessive infusion of 0.9% NaCl?
What condition is associated with a decrease in Strong Ion Difference (SID) due to an excessive infusion of 0.9% NaCl?
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What is the primary reason why isotonic crystalloids are used to treat ECF deficits?
What is the primary reason why isotonic crystalloids are used to treat ECF deficits?
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What is the approximate percentage of infused isotonic crystalloid volume that remains intravascular in healthy patients after 30 minutes?
What is the approximate percentage of infused isotonic crystalloid volume that remains intravascular in healthy patients after 30 minutes?
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How does surgery and anesthesia influence the distribution of isotonic crystalloids?
How does surgery and anesthesia influence the distribution of isotonic crystalloids?
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What is magnesium primarily used to treat?
What is magnesium primarily used to treat?
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Which of the following is NOT a patient factor that increases the risk of hypervolemia during surgery?
Which of the following is NOT a patient factor that increases the risk of hypervolemia during surgery?
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Identify the potential risks associated with fluid overload during surgery:
Identify the potential risks associated with fluid overload during surgery:
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Which of the listed factors contributes to decreased venous return during surgery?
Which of the listed factors contributes to decreased venous return during surgery?
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Which of the following is NOT a consequence of hypervolemia during surgery?
Which of the following is NOT a consequence of hypervolemia during surgery?
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Which of the following is a potential benefit of goal-directed fluid therapy?
Which of the following is a potential benefit of goal-directed fluid therapy?
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Which of the following is true regarding goal-directed fluid therapy?
Which of the following is true regarding goal-directed fluid therapy?
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Which of the following contributes to hypervolemia during general anesthesia?
Which of the following contributes to hypervolemia during general anesthesia?
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Which of the following is NOT a common electrolyte found in Normosol and Plasma-Lyte?
Which of the following is NOT a common electrolyte found in Normosol and Plasma-Lyte?
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What is the primary dietary source from which iron is absorbed?
What is the primary dietary source from which iron is absorbed?
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Which condition is NOT a common cause of iron deficiency anemia?
Which condition is NOT a common cause of iron deficiency anemia?
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What is the effect of vitamin C on iron absorption?
What is the effect of vitamin C on iron absorption?
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Which of the following best describes agglutinogen?
Which of the following best describes agglutinogen?
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What happens to red blood cells as they age beyond 14 to 21 days?
What happens to red blood cells as they age beyond 14 to 21 days?
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What is the minimum acceptable hemoglobin level for a patient receiving a blood transfusion?
What is the minimum acceptable hemoglobin level for a patient receiving a blood transfusion?
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Which factor does NOT influence the need for blood transfusion?
Which factor does NOT influence the need for blood transfusion?
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What is the risk associated with blood transfusions after 14 days?
What is the risk associated with blood transfusions after 14 days?
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What is the consequence of hemoglobin synthesis mobilizing tissue iron stores?
What is the consequence of hemoglobin synthesis mobilizing tissue iron stores?
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What is a common consequence of sickle cell disease?
What is a common consequence of sickle cell disease?
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What is the goal for platelet (PLT) replacement therapy?
What is the goal for platelet (PLT) replacement therapy?
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What is the recommended volume for one unit of pRBCs?
What is the recommended volume for one unit of pRBCs?
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Which of the following is a critical role of red blood cells (RBCs) in hemostasis?
Which of the following is a critical role of red blood cells (RBCs) in hemostasis?
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What is the target hemoglobin (Hgb) level in coagulopathy management?
What is the target hemoglobin (Hgb) level in coagulopathy management?
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What is the primary risk associated with aggressive crystalloid resuscitation in severe trauma?
What is the primary risk associated with aggressive crystalloid resuscitation in severe trauma?
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Which component is crucial in management for a patient experiencing postpartum hemorrhage (PPH)?
Which component is crucial in management for a patient experiencing postpartum hemorrhage (PPH)?
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What is the typical use of antifibrinolytic agents in clinical scenarios?
What is the typical use of antifibrinolytic agents in clinical scenarios?
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What is the recommended ratio of blood components for trauma-associated coagulopathy management?
What is the recommended ratio of blood components for trauma-associated coagulopathy management?
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What is the primary effect of citrate toxicity during blood transfusion?
What is the primary effect of citrate toxicity during blood transfusion?
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What is a common potential cause of postpartum hemorrhage (PPH)?
What is a common potential cause of postpartum hemorrhage (PPH)?
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What is the preferred type of IV access for blood transfusions to reduce complications?
What is the preferred type of IV access for blood transfusions to reduce complications?
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What is the purpose of using filters in blood transfusions?
What is the purpose of using filters in blood transfusions?
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Which statement regarding red blood cell (RBC) storage is true?
Which statement regarding red blood cell (RBC) storage is true?
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What is the preferred fluid for dilution when administering blood products?
What is the preferred fluid for dilution when administering blood products?
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What is the primary indication for using fresh frozen plasma (FFP)?
What is the primary indication for using fresh frozen plasma (FFP)?
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Cryoprecipitate is rich in which factor crucial for hemostasis?
Cryoprecipitate is rich in which factor crucial for hemostasis?
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What needs to be monitored to avoid thrombus formation during platelet transfusions?
What needs to be monitored to avoid thrombus formation during platelet transfusions?
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What adverse effect is associated with transfusion-transmissible infections?
What adverse effect is associated with transfusion-transmissible infections?
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Which condition is characterized by acute lung injury within 6 hours of transfusion?
Which condition is characterized by acute lung injury within 6 hours of transfusion?
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What is a critical factor influencing Graft versus Host Disease (GVHD) after platelet transfusions?
What is a critical factor influencing Graft versus Host Disease (GVHD) after platelet transfusions?
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How much does one unit of platelets increase the count per microL?
How much does one unit of platelets increase the count per microL?
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What is the minimum acceptable platelet count for surgical patients?
What is the minimum acceptable platelet count for surgical patients?
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What clinical indication warrants the administration of plasma?
What clinical indication warrants the administration of plasma?
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Flashcards
Bleeding
Bleeding
Loss of blood that can lead to coagulopathy and shock.
Coagulopathy
Coagulopathy
A blood disorder affecting coagulation, often due to factors like hemodilution.
Hypervolemia
Hypervolemia
Excessive fluid volume in the body, risking reduced tissue perfusion.
Goal-Directed Fluid Therapy
Goal-Directed Fluid Therapy
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Tissue Edema
Tissue Edema
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Cardiac Output
Cardiac Output
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EVAPORATIVE losses
EVAPORATIVE losses
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Intravenous Fluid Therapy
Intravenous Fluid Therapy
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Hypotonic Crystalloids
Hypotonic Crystalloids
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Use of Hypotonic Crystalloids
Use of Hypotonic Crystalloids
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Examples of Hypotonic Crystalloids
Examples of Hypotonic Crystalloids
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Hypertonic Crystalloids
Hypertonic Crystalloids
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Use of Hypertonic Crystalloids
Use of Hypertonic Crystalloids
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Examples of Hypertonic Crystalloids
Examples of Hypertonic Crystalloids
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Perioperative Crystalloid Administration
Perioperative Crystalloid Administration
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Fluid Balance Goal
Fluid Balance Goal
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Dietary Deficiency Anemia
Dietary Deficiency Anemia
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Iron Absorption
Iron Absorption
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Iron Storage in Erythrocytes
Iron Storage in Erythrocytes
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Iron Deficiency Causes
Iron Deficiency Causes
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Agglutination
Agglutination
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RBC Aging Changes
RBC Aging Changes
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RBC Transfusion Guidelines
RBC Transfusion Guidelines
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Rh Factor
Rh Factor
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Iron Supplementation Effects
Iron Supplementation Effects
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Kidney Disease Anemia
Kidney Disease Anemia
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Serum Mg2+ Levels
Serum Mg2+ Levels
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Crystalloids
Crystalloids
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Tonicity
Tonicity
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Isotonic Solutions
Isotonic Solutions
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Hypertonic Solutions
Hypertonic Solutions
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Hypotonic Solutions
Hypotonic Solutions
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Strong Ion Difference (SID)
Strong Ion Difference (SID)
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Effective SID
Effective SID
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Volume Kinetics of Isotonic Crystalloids
Volume Kinetics of Isotonic Crystalloids
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Intravenous Fluid Use
Intravenous Fluid Use
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IV Access
IV Access
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Transfusion Filters
Transfusion Filters
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RBC Storage
RBC Storage
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Compatible Fluids
Compatible Fluids
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Fresh Frozen Plasma (FFP)
Fresh Frozen Plasma (FFP)
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Plasma Indications
Plasma Indications
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Cryoprecipitate
Cryoprecipitate
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Platelet Lifespan
Platelet Lifespan
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Platelet Administration
Platelet Administration
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TRALI
TRALI
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Graft vs Host Disease
Graft vs Host Disease
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Transfusion Overload (TACO)
Transfusion Overload (TACO)
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Minimum PLT Count
Minimum PLT Count
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Cryoprecipitate Administration
Cryoprecipitate Administration
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Leukoreduction
Leukoreduction
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1:1:1 Ratio
1:1:1 Ratio
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Coagulopathy Management
Coagulopathy Management
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Antifibrinolytic agents
Antifibrinolytic agents
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Dilutional coagulopathy
Dilutional coagulopathy
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Massive Transfusion for Trauma
Massive Transfusion for Trauma
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Postpartum Hemorrhage (PPH)
Postpartum Hemorrhage (PPH)
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Tranexamic acid
Tranexamic acid
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RBCs in Hemostasis
RBCs in Hemostasis
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Hypocalcemia in Transfusions
Hypocalcemia in Transfusions
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Study Notes
Electrolytes and Minerals
- Sodium is primarily found in the extracellular fluid (ECF)
- Normal levels range from 135-145 mEq/L
- Functions include water balance, osmotic pressure control, nerve impulse conduction, and muscle contraction
Sodium Alterations
-
Sodium intake comes from diet and intravenous fluids
-
Homeostasis is maintained by the kidneys, reabsorbing most filtered sodium
-
Hormones like RAAS, ADH, and SNS regulate BP and intravascular volume
-
Parathyroid hormone and natriuretic peptides stimulate sodium excretion
-
Hyponatremia:
- Can be caused by hypervolemia (e.g., CHF, cirrhosis) or hypovolemia (e.g., diarrhea, vomiting)
- Other causes include salt wasting or euvolemia (e.g., adrenal insufficiency, polydipsia)
- Symptoms include nausea, vomiting, muscle cramps
- Treatment depends on the underlying cause
-
Hypernatremia:
- Caused by water loss (e.g., fever, sweating, osmotic diuresis)
- Other causes include nephrogenic or central diabetes insipidus, or excessive sodium administration.
- Symptoms may include dehydration signs, altered mental status, seizures, or coma
- Treatment depends on the underlying cause
Potassium
- Primarily found intracellularly (98%)
- Normal levels range from 3.5-5.2 mEq/L
- Functions include cell membrane excitability (nerves, muscles, heart), kidney function, and influences osmotic pressure
- Affects endothelial-dependent vasodilation, thrombus formation, and platelet activation
Potassium Alterations
- Hypokalemia:
- Can be caused by diuretics, beta agonists, insulin, antibiotics, catecholamines
- Also results from GI losses (e.g., laxatives, bowel prep)
- Symptoms include muscle weakness, muscle cramps, rhabdomyolysis, ileus, nausea, vomiting, and dysrhythmias
- These include T wave inversion, U waves, tachyarrhythmias (torsades, AFib)
- Hyperkalemia:
- Caused by potassium redistribution or inhibition of secretion (e.g., medications like SCh, digitalis), aldosterone antagonists, beta antagonists, NSAIDs, chemotherapy, and PRBC transfusion.
- Symptoms include paresthesias, muscle weakness, widened QRS complexes, prolonged PR intervals, and cardiac conduction blockade leading to VF and asystole
Magnesium
- Primarily intracellular (bone, muscle, soft tissues)
- Normal levels range from 1.7-2.4 mg/dL
- Functions include protein synthesis, nucleic acid stability, neuromuscular function, muscle relaxation, antiarrhythmic effects, vasodilation, stabilization of the BBB, and reducing anesthetic requirements
Magnesium Alterations
- Hypomagnesemia:
- Caused by dietary deficiency, GI malabsorption (e.g., alcoholism, vomiting, laxatives), and renal losses (e.g., diuretics, nephropathy)
- Symptoms include prolonged PR and QT intervals, diminished T waves, torsades, arrhythmias, weakness, tetany, fasciculations, convulsions, nausea, and vomiting
- Hypermagnesemia:
- Caused by excessive magnesium administration
- Symptoms include widened QRS complexes, conduction blockade, asystole, hypotension, respiratory depression, muscle paralysis, diminished reflexes, and narcosis
Calcium
- Predominantly stored in the skeleton
- Normal levels range from 8.5-10.5 mg/dL
- Functions include musculoskeletal strength, neuromuscular transmission, cardiac muscle contractility, relaxation, and rhythm; vascular motor tone, and intracellular signaling
- Homeostasis is maintained by endocrine control through vitamin D, parathyroid hormone, and calcitonin; regulating intestinal absorption, renal reabsorption, and bone turnover
Calcium Alterations
- Hypocalcemia:
- Can be caused by decreased albumin, vitamin D deficiency, or disorders like hypoparathyroidism, pancreatitis, chronic renal failure, and citrate binding during transfusions.
- Symptoms include neuromuscular issues such as twitching, spasms, paresthesias, tetany, seizures, and dysrhythmias
- Hypercalcemia:
- Caused by disorders like hyperparathyroidism, or parathyroid adenoma
- Additional causes include malignancies, excessive dietary supplementation, or medication-induced issues (e.g., diuretics, lithium)
- Symptoms include GI smooth muscle relaxation (nausea, vomiting, constipation), decreased neuromuscular transmission (lethargy, hypotonia), polyuria, dehydration, renal stones, and shortened QT intervals
Phosphate
- Primarily intracellular (bone, soft tissue)
- Normal level range 3-4.5 mg/dL
- Functions include energy metabolism, intracellular signaling (cAMP), immune system regulation, coagulation cascade regulation, and acid-base balance
Fluid Compartments
- Body fluid is primarily composed of intracellular (2/3) and extracellular fluid (1/3)
- Extracellular fluid is primarily interstitial (~80%) and plasma (~20%)
Plasma Composition
- Primarily water (90%)
- Contains proteins (albumin, globulins) with roles in oncotic pressure, transport, pH, and coagulation
- Electrolytes and small molecules like salts, nutrients, waste products, hormones, and blood cells are in <1% concentration
Compartmental Fluid Movement
- Small ions readily move between plasma and interstitial fluid
- Larger molecules are prevented from free movement by tight junctions of endothelial cells and the endothelial glycocalyx layer
Monitoring Intravascular Volume Status
- Static parameters: Blood pressure, heart rate, urine output, mixed venous oxygen saturation are assessed but may lack sensitivity for identifying fluid imbalances
- Dynamic parameters: Respiratory variations in arterial waveform, end-expiratory occlusion test, ultrasound technologies (esophageal doppler, echocardiography) are helpful to assess fluid responsiveness but can have limitations in specific conditions
Crystalloids
- Crystalloid solutions contain soluble electrolytes and small molecules
- Classified by tonicity: Isotonic (e.g., 0.9% NaCl, Lactated Ringers), Hypotonic (e.g., 0.45% NaCl), Hypertonic (e.g., Dextrose 5% in NS)
- Isotonic solutions contain electrolytes similar to extracellular fluid and remain in the blood vessels
Colloids
- Colloids contain large molecules
- Examples: Albumin, Hydroxyethyl Starches (HES)
- Used for expansion of intravascular volume
Blood Physiology and Blood Transfusion
- Red blood cells: Essential for oxygen transport
- White blood cells: Part of the immune system
- Platelets: Crucial for hemostasis
Anemia and Iron Deficiency
- Anemia is a reduced RBC/hemoglobin count
- Iron deficiency is a possible cause of anemia
Transfusion-Associated Complications
- TACO: Transfusion-associated circulatory overload
- TRALI: Transfusion-related acute lung injury
- Citrate toxicity: Risk from citrate use in stored blood
- Agglutination: Antibodies in recipient reacting with antigens on donor blood
Massive Transfusion
- Associated with life-threatening, uncontrolled bleeding
- Severe complications including coagulopathy and hypothermia
Coagulopathy Management
- Aims to correct coagulation abnormalities that arise through interventions including transfusion or other treatments
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Description
Test your knowledge on the use of crystalloids in a perioperative setting. This quiz covers the differences between hypotonic, hypertonic, and isotonic solutions, their effects on hemodynamic monitoring, and guidelines for fluid administration during surgery. Challenge yourself to understand the complexities of fluid management.