Perinatal Asphyxia: Pathophysiology and Clinical Staging

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Questions and Answers

What is the diagnostic criteria for perinatal asphyxia?

  • Apgar score of 5 at 5 minutes
  • Neonatal encephalopathy without multi-system organ dysfunction
  • Evidence of severe acidosis at birth (PH< 7) (correct)
  • Normal Apgar scores at 1, 5, and 10 minutes

What percentage of affected infants die due to moderate or severe HIE?

  • 10-60% (correct)
  • 1-5%
  • 0-20%
  • 70-90%

What is the definition of hypoxia?

  • Reduction or cessation of blood flow to the tissues
  • Partial or complete lack of oxygen in the tissues (correct)
  • Impaired blood gas exchange
  • Multi-system organ dysfunction

What does Apgar score assess?

<p>The condition of the baby directly after birth (D)</p> Signup and view all the answers

What is the impact on survivors of perinatal asphyxia?

<p>At least 25% of survivors have long-term neurodevelopmental sequelae (C)</p> Signup and view all the answers

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Study Notes

Perinatal Asphyxia

  • Diagnostic criteria for perinatal asphyxia include a lack of breathing, a slow heart rate, and a low Apgar score at birth.
  • Additionally, presence of fetal distress, meconium-stained amniotic fluid, and umbilical artery acidosis are also considered diagnostic criteria.

Mortality Rate

  • Moderate or severe hypoxic-ischemic encephalopathy (HIE) results in death for approximately 20-50% of affected infants.

Hypoxia

  • Hypoxia is defined as a state of inadequate oxygen supply to the body's tissues.

Apgar Score

  • Apgar score assesses the newborn's overall health and vitality at one and five minutes after birth, taking into account heart rate, breathing, muscle tone, reflexes, and color.

Impact on Survivors

  • Survivors of perinatal asphyxia are at risk of developing long-term neurological and cognitive impairments, including cerebral palsy, epilepsy, and learning disabilities.
  • Additionally, survivors may experience developmental delays, motor impairments, and vision or hearing problems.

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