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What is the first-line eradication therapy for H. pylori?
What is the first-line eradication therapy for H. pylori?
- A 7-day course of dual-therapy with clarithromycin and a PPI
- A 7-day course of triple-therapy with amoxicillin, clarithromycin/metronidazole, and a PPI (correct)
- A 14-day course of quadruple-therapy with amoxicillin, clarithromycin, metronidazole, and a PPI
- A 10-day course of dual-therapy with amoxicillin and a PPI
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Study Notes
- Peptic Ulcer Disease (PUD) is a lesion in the digestive tract caused by pepsin and stomach acid.
- PUD occurs mainly in the stomach or duodenum.
- There are two types of PUD: gastric and duodenal ulcers.
- Risk factors for PUD include smoking, acidic drinks, medications, H. pylori infection, age, gender, and genetic factors.
- PUD occurs when the balance between aggressive factors and mucosal defensive mechanisms are disrupted.
- H. pylori and NSAIDs are important factors in the formation of peptic ulcers.
- Symptoms of PUD include epigastric pain, dyspepsia, heartburn, haematemesis, melaena, and anaemia.
- Complications of PUD can include acute upper GI bleed or perforation.
- The definitive diagnosis of PUD is made on endoscopic examination.
- Management of PUD includes non-pharmacologic therapy, pharmacologic therapy, and surgical treatment.
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