Peptic Ulcer Disease: Pathophysiology and Management

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What is the typical location of Peptic Ulcer Disease?

Small intestine

Stomach and duodenum (correct)

Lower esophagus

All of the above

What is the primary cause of mucosal injury and peptic ulcer?

Consumption of acidic drinks

Infection by H pylori

Imbalance between gastric acid secretion and gastroduodenal mucosal defense (correct)

Smoking

What is the result of back diffusion of hydrogen ions?

Increased gastric acid secretion

Gastroduodenal mucosal defense strengthening

Epithelial cell injury (correct)

Epithelial cell repair

What is a lifestyle risk factor for Peptic Ulcer Disease?

Smoking Signup and view all the answers

What is the effect of aggressive factors on the mucosal defense?

Weakening of the mucosal defense Signup and view all the answers

What is the location of the ulcer in the majority of Peptic Ulcer Disease cases?

Both stomach and duodenum Signup and view all the answers

What happens when an ulcer erodes through the entire wall of the stomach or duodenal wall?

Perforation Signup and view all the answers

What is the principle of H.pylori eradication therapy?

Reduce acid and pepsin secretion Signup and view all the answers

What is the indication for H.pylori eradication therapy?

Both b and c Signup and view all the answers

What is the function of Prostaglandin Analogs in the management of peptic ulcers?

Reduce gastric acid and enhance mucosal resistance to injury Signup and view all the answers

What is the treatment for narrowing and pyloric obstruction?

Surgery Signup and view all the answers

What is the function of Antacids in the management of peptic ulcers?

Neutralize acid and prevent pepsin formation Signup and view all the answers

What is the most common mode of transmission of Helicobacter pylori?

Through fecal-oral route or oral-oral route Signup and view all the answers

At what age is the Duodenal peptic ulcer most commonly found?

Between 30-40 years Signup and view all the answers

What is the term for the passage of black tarry stool?

Melena Signup and view all the answers

What is the purpose of an esophagogastrodeuodenoscopy (EGD) in diagnosing peptic ulcers?

All of the above Signup and view all the answers

What is the purpose of the Urea Breath Testing in diagnosing peptic ulcers?

To detect H. pylori infection Signup and view all the answers

In which patients is endoscopy required?

Those with dysphagia, weight loss, vomiting, or anorexia Signup and view all the answers