9 Questions
What is the primary cause of duodenal ulcers according to the passage?
Increased gastric acid secretion due to H.pylori infection
What is the proposed mechanism by which H.pylori infection leads to increased gastric acid secretion in duodenal ulcers?
Both (a) and (b)
What is the relationship between H.pylori eradication and gastric acid secretion in duodenal ulcer patients?
Gastric acid secretion remains mildly elevated even after H.pylori eradication, suggesting a genetic component
According to the passage, which of the following is NOT a risk factor for gastric ulcers?
Chronic salicylate or NSAID use
What is the relationship between H.pylori infection and gastric acid secretion in gastric ulcers?
H.pylori infection leads to decreased gastric acid secretion in gastric ulcers
Which of the following is the most common location for a peptic ulcer to occur?
Duodenal bulb
What is the primary cause of peptic ulcers that are not due to Helicobacter pylori infection?
Nonsteroidal anti-inflammatory drugs (NSAIDs)
What is the relationship between Helicobacter pylori and chronic gastritis?
H. pylori is found in those with chronic gastritis, which can lead to gastric cancer.
Which of the following is not considered a risk factor for peptic ulcer disease?
Stress
Study Notes
- Duodenal Ulcer (DU) is characterized by mild gastric acid hypersecretion, primarily due to increased gastrin release from H.pylori infection, leading to stimulation of antral G cells and reduced somatostatin production by D cells.
- The increased parietal cell mass in DU patients results in an exaggerated acid response to gastrin, which normalizes with eradication of H.pylori, but some patients may still have elevated acid output post-eradication, suggesting a possible genetic component to gastric acid hypersecretion.
- H.pylori infection can also elevate serum pepsinogen levels and compromise mucosal defenses in the duodenum by affecting gastric metaplasia patches, which are linked to gastric acid hypersecretion or rapid gastric emptying.
- Risk factors for DU include factors like glucocorticoids, NSAIDs, chronic renal failure, cirrhosis, and chronic lung disease.
- Peptic Ulcer Disease (PUD) most commonly occurs in the duodenal bulb (DU) and stomach (GU), with H.pylori infection being a primary cause, while chronic use of salicylates or NSAIDs can also lead to gastric ulcers and increase the risk of bleeding or perforation.
Learn about the causes, symptoms, and risk factors of Peptic Ulcer Disease (PUD). Understand how aggressive factors like gastric acid and Helicobacter pylori can lead to ulcer formation. Explore the different locations where ulcers may occur.
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