Penile and Testicular Tumors: PeIN and SCC

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Which type of penile tumor is most common?

Bowen's disease

Verrucous carcinoma

Warty basaloid

Squamous cell carcinoma (correct)

What is a common risk factor for penile squamous cell carcinoma?

Use of talcum powder

Excessive sun exposure

Alcohol consumption

Presence of an intact foreskin (correct)

Which type of penile tumor presents with mitosis in the upper third layer and HPV positivity?

Bowen's disease (correct)

Warty basaloid

Verrucous carcinoma

Squamous cell carcinoma

What is a common treatment option for penile tumors?

Excision Signup and view all the answers

Which variant of PeIN is characterized by papillary growth?

Warty Signup and view all the answers

What is a pathological finding associated with penile squamous cell carcinoma?

Prominent nucleoli Signup and view all the answers

Which penile tumor type has excellent prognosis and tends to recur?

Verrucous carcinoma Signup and view all the answers

What gene is affected in the pathogenesis of penile tumors, leading to degradation and inactivation?

p53 Signup and view all the answers

Which factor increases the risk of metastasis in penile squamous cell carcinoma?

High histologic grade Signup and view all the answers

What is the fibrous capsule that extends into the testis known as?

Tunica albuginea Signup and view all the answers

Which type of cells in the testes initiate spermatogenesis?

Spermatogenic cells Signup and view all the answers

In which tissue are Leydig cells located?

Interstitial tissue Signup and view all the answers

Which type of cells are primarily found in the seminiferous tubules?

Sertoli cells Signup and view all the answers

Which age group is most prone to testicular tumors?

25-29 years Signup and view all the answers

Which nodes are affected by the lymphatic spread of testicular tumors?

Periaortic nodes Signup and view all the answers

What is the most common type of tumor in men aged 25-29?

Seminoma Signup and view all the answers

Which of the following is a risk factor for testicular tumors?

Cryptorchidism Signup and view all the answers

What does an elevated AFP suggest in the context of testicular tumors?

Yolk sac tumor components Signup and view all the answers

What are the three elevations in serum seen in seminoma?

PLAP, LDH, hCG Signup and view all the answers

Which chromosome sequences are overrepresented in seminoma?

KRAS, CCND2, NANOG Signup and view all the answers

Which of the following is a characteristic pathologic finding in seminoma?

Prominent nucleoli Signup and view all the answers

Which tumor is characterized by the presence of cytokeratin and hCG markers?

Choriocarcinoma Signup and view all the answers

What is a poor prognostic factor in seminoma?

Sarcomatous components Signup and view all the answers

Which tumor type is NOT related to classic seminoma?

Spermatocytic tumor Signup and view all the answers

Which of the following is a specific marker for choriocarcinoma?

HCG Signup and view all the answers