Penile and Testicular Tumors: PeIN and SCC
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Questions and Answers

Which type of penile tumor is most common?

  • Bowen's disease
  • Verrucous carcinoma
  • Warty basaloid
  • Squamous cell carcinoma (correct)
  • What is a common risk factor for penile squamous cell carcinoma?

  • Use of talcum powder
  • Excessive sun exposure
  • Alcohol consumption
  • Presence of an intact foreskin (correct)
  • Which type of penile tumor presents with mitosis in the upper third layer and HPV positivity?

  • Bowen's disease (correct)
  • Warty basaloid
  • Verrucous carcinoma
  • Squamous cell carcinoma
  • What is a common treatment option for penile tumors?

    <p>Excision</p> Signup and view all the answers

    Which variant of PeIN is characterized by papillary growth?

    <p>Warty</p> Signup and view all the answers

    What is a pathological finding associated with penile squamous cell carcinoma?

    <p>Prominent nucleoli</p> Signup and view all the answers

    Which penile tumor type has excellent prognosis and tends to recur?

    <p>Verrucous carcinoma</p> Signup and view all the answers

    What gene is affected in the pathogenesis of penile tumors, leading to degradation and inactivation?

    <p>p53</p> Signup and view all the answers

    Which factor increases the risk of metastasis in penile squamous cell carcinoma?

    <p>High histologic grade</p> Signup and view all the answers

    What is the fibrous capsule that extends into the testis known as?

    <p>Tunica albuginea</p> Signup and view all the answers

    Which type of cells in the testes initiate spermatogenesis?

    <p>Spermatogenic cells</p> Signup and view all the answers

    In which tissue are Leydig cells located?

    <p>Interstitial tissue</p> Signup and view all the answers

    Which type of cells are primarily found in the seminiferous tubules?

    <p>Sertoli cells</p> Signup and view all the answers

    Which age group is most prone to testicular tumors?

    <p>25-29 years</p> Signup and view all the answers

    Which nodes are affected by the lymphatic spread of testicular tumors?

    <p>Periaortic nodes</p> Signup and view all the answers

    What is the most common type of tumor in men aged 25-29?

    <p>Seminoma</p> Signup and view all the answers

    Which of the following is a risk factor for testicular tumors?

    <p>Cryptorchidism</p> Signup and view all the answers

    What does an elevated AFP suggest in the context of testicular tumors?

    <p>Yolk sac tumor components</p> Signup and view all the answers

    What are the three elevations in serum seen in seminoma?

    <p>PLAP, LDH, hCG</p> Signup and view all the answers

    Which chromosome sequences are overrepresented in seminoma?

    <p>KRAS, CCND2, NANOG</p> Signup and view all the answers

    Which of the following is a characteristic pathologic finding in seminoma?

    <p>Prominent nucleoli</p> Signup and view all the answers

    Which tumor is characterized by the presence of cytokeratin and hCG markers?

    <p>Choriocarcinoma</p> Signup and view all the answers

    What is a poor prognostic factor in seminoma?

    <p>Sarcomatous components</p> Signup and view all the answers

    Which tumor type is NOT related to classic seminoma?

    <p>Spermatocytic tumor</p> Signup and view all the answers

    Which of the following is a specific marker for choriocarcinoma?

    <p>HCG</p> Signup and view all the answers

    Which tumor has a pathologic finding of containing varying cell types from lymphocyte size to giant cells?

    <p>Spermatocytic tumor</p> Signup and view all the answers

    What is noted to be the only abnormal serum marker for some seminomas?

    <p>LDH</p> Signup and view all the answers

    Which tumor type is characterized by having Alpha-fetoprotein (AFP) abnormal?

    <p>Yolk sac tumor</p> Signup and view all the answers

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