Penile and Testicular Tumors: PeIN and SCC
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Questions and Answers

Which type of penile tumor is most common?

  • Bowen's disease
  • Verrucous carcinoma
  • Warty basaloid
  • Squamous cell carcinoma (correct)

What is a common risk factor for penile squamous cell carcinoma?

  • Use of talcum powder
  • Excessive sun exposure
  • Alcohol consumption
  • Presence of an intact foreskin (correct)

Which type of penile tumor presents with mitosis in the upper third layer and HPV positivity?

  • Bowen's disease (correct)
  • Warty basaloid
  • Verrucous carcinoma
  • Squamous cell carcinoma

What is a common treatment option for penile tumors?

<p>Excision (C)</p> Signup and view all the answers

Which variant of PeIN is characterized by papillary growth?

<p>Warty (A)</p> Signup and view all the answers

What is a pathological finding associated with penile squamous cell carcinoma?

<p>Prominent nucleoli (D)</p> Signup and view all the answers

Which penile tumor type has excellent prognosis and tends to recur?

<p>Verrucous carcinoma (C)</p> Signup and view all the answers

What gene is affected in the pathogenesis of penile tumors, leading to degradation and inactivation?

<p>p53 (A)</p> Signup and view all the answers

Which factor increases the risk of metastasis in penile squamous cell carcinoma?

<p>High histologic grade (D)</p> Signup and view all the answers

What is the fibrous capsule that extends into the testis known as?

<p>Tunica albuginea (B)</p> Signup and view all the answers

Which type of cells in the testes initiate spermatogenesis?

<p>Spermatogenic cells (C)</p> Signup and view all the answers

In which tissue are Leydig cells located?

<p>Interstitial tissue (C)</p> Signup and view all the answers

Which type of cells are primarily found in the seminiferous tubules?

<p>Sertoli cells (A)</p> Signup and view all the answers

Which age group is most prone to testicular tumors?

<p>25-29 years (C)</p> Signup and view all the answers

Which nodes are affected by the lymphatic spread of testicular tumors?

<p>Periaortic nodes (A)</p> Signup and view all the answers

What is the most common type of tumor in men aged 25-29?

<p>Seminoma (C)</p> Signup and view all the answers

Which of the following is a risk factor for testicular tumors?

<p>Cryptorchidism (B)</p> Signup and view all the answers

What does an elevated AFP suggest in the context of testicular tumors?

<p>Yolk sac tumor components (D)</p> Signup and view all the answers

What are the three elevations in serum seen in seminoma?

<p>PLAP, LDH, hCG (C)</p> Signup and view all the answers

Which chromosome sequences are overrepresented in seminoma?

<p>KRAS, CCND2, NANOG (C)</p> Signup and view all the answers

Which of the following is a characteristic pathologic finding in seminoma?

<p>Prominent nucleoli (B)</p> Signup and view all the answers

Which tumor is characterized by the presence of cytokeratin and hCG markers?

<p>Choriocarcinoma (D)</p> Signup and view all the answers

What is a poor prognostic factor in seminoma?

<p>Sarcomatous components (C)</p> Signup and view all the answers

Which tumor type is NOT related to classic seminoma?

<p>Spermatocytic tumor (B)</p> Signup and view all the answers

Which of the following is a specific marker for choriocarcinoma?

<p>HCG (A)</p> Signup and view all the answers

Which tumor has a pathologic finding of containing varying cell types from lymphocyte size to giant cells?

<p>Spermatocytic tumor (B)</p> Signup and view all the answers

What is noted to be the only abnormal serum marker for some seminomas?

<p>LDH (D)</p> Signup and view all the answers

Which tumor type is characterized by having Alpha-fetoprotein (AFP) abnormal?

<p>Yolk sac tumor (A)</p> Signup and view all the answers

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