Penile and Testicular Tumors Overview
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Questions and Answers

Which type of penile neoplasm is characterized by sharply marginated, erythematous, scaly patch or plaque?

  • Warty
  • Squamous Cell Carcinoma
  • Basaloid
  • Bowen's Disease (correct)

What is a common risk factor for developing penile squamous cell carcinoma?

  • HPV infection (correct)
  • High education level
  • Low poverty areas
  • Dry skin

Which gene is affected in the pathogenesis of penile squamous cell carcinoma, leading to the degradation and inactivation of p53 and pRb?

  • E6 (correct)
  • KRAS
  • BRAF
  • EGFR

Which type of penile neoplasm is characterized by slow growth and may recur, with no P16 overexpression?

<p>Verrucous Carcinoma (D)</p> Signup and view all the answers

What is a common feature of the pathological findings of penile squamous cell carcinoma?

<p>Prominent nucleoli (A)</p> Signup and view all the answers

What is the most common treatment approach for penile squamous cell carcinoma?

<p>Excision (partial/total penectomy), with or without inguinal lymph node dissection (B)</p> Signup and view all the answers

What is a common serum marker seen in choriocarcinoma?

<p>hCG (A)</p> Signup and view all the answers

Which histological marker is typically negative in seminoma?

<p>Cytokeratin (D)</p> Signup and view all the answers

What is a possible genetic overrepresentation in seminoma?

<p>KRAS (A)</p> Signup and view all the answers

Which testicular germ cell tumor may present with sarcomatous components and negative PLAP?

<p>Spermatocytic tumor (D)</p> Signup and view all the answers

Which serum marker correlates with the overall tumor burden in testicular germ cell tumors?

<p>Lactate dehydrogenase (LDH) (A)</p> Signup and view all the answers

What is a characteristic pathologic feature of seminoma?

<p>Uniform tumor cells with clear cytoplasm and prominent nucleoli (A)</p> Signup and view all the answers

Which cells are responsible for initiating spermatogenesis in the testes?

<p>Sertoli cells (A)</p> Signup and view all the answers

What is the most common solid tumor in males aged 15-35?

<p>Seminoma (B)</p> Signup and view all the answers

Where do germ cell tumors usually spread hematogenously?

<p>Supraclavicular nodes (D)</p> Signup and view all the answers

What is the most common type of tumor in men aged 25-29 years?

<p>Seminoma (C)</p> Signup and view all the answers

Which risk factor is associated with an increased likelihood of developing testicular germ cell tumors?

<p>Family history (A)</p> Signup and view all the answers

What is the characteristic feature of teratoma tumors in adults?

<p>Malignant behavior (C)</p> Signup and view all the answers

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