Penile and Testicular Tumors Overview
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Questions and Answers

Which type of penile neoplasm is characterized by sharply marginated, erythematous, scaly patch or plaque?

  • Warty
  • Squamous Cell Carcinoma
  • Basaloid
  • Bowen's Disease (correct)
  • What is a common risk factor for developing penile squamous cell carcinoma?

  • HPV infection (correct)
  • High education level
  • Low poverty areas
  • Dry skin
  • Which gene is affected in the pathogenesis of penile squamous cell carcinoma, leading to the degradation and inactivation of p53 and pRb?

  • E6 (correct)
  • KRAS
  • BRAF
  • EGFR
  • Which type of penile neoplasm is characterized by slow growth and may recur, with no P16 overexpression?

    <p>Verrucous Carcinoma</p> Signup and view all the answers

    What is a common feature of the pathological findings of penile squamous cell carcinoma?

    <p>Prominent nucleoli</p> Signup and view all the answers

    What is the most common treatment approach for penile squamous cell carcinoma?

    <p>Excision (partial/total penectomy), with or without inguinal lymph node dissection</p> Signup and view all the answers

    What is a common serum marker seen in choriocarcinoma?

    <p>hCG</p> Signup and view all the answers

    Which histological marker is typically negative in seminoma?

    <p>Cytokeratin</p> Signup and view all the answers

    What is a possible genetic overrepresentation in seminoma?

    <p>KRAS</p> Signup and view all the answers

    Which testicular germ cell tumor may present with sarcomatous components and negative PLAP?

    <p>Spermatocytic tumor</p> Signup and view all the answers

    Which serum marker correlates with the overall tumor burden in testicular germ cell tumors?

    <p>Lactate dehydrogenase (LDH)</p> Signup and view all the answers

    What is a characteristic pathologic feature of seminoma?

    <p>Uniform tumor cells with clear cytoplasm and prominent nucleoli</p> Signup and view all the answers

    Which cells are responsible for initiating spermatogenesis in the testes?

    <p>Sertoli cells</p> Signup and view all the answers

    What is the most common solid tumor in males aged 15-35?

    <p>Seminoma</p> Signup and view all the answers

    Where do germ cell tumors usually spread hematogenously?

    <p>Supraclavicular nodes</p> Signup and view all the answers

    What is the most common type of tumor in men aged 25-29 years?

    <p>Seminoma</p> Signup and view all the answers

    Which risk factor is associated with an increased likelihood of developing testicular germ cell tumors?

    <p>Family history</p> Signup and view all the answers

    What is the characteristic feature of teratoma tumors in adults?

    <p>Malignant behavior</p> Signup and view all the answers

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