Questions and Answers
What is the generic name for Penicillin G?
no generic name
What is the therapeutic class of Penicillin G?
Antibacterial
What is the pharmacologic class of Penicillin G?
Cell wall inhibitor; natural penicillin
What are the common uses of Penicillin G?
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What are the administration alerts for Penicillin G?
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What are the most common adverse effects of Penicillin G?
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Is hypersensitivity to Penicillin the only contraindication for its use?
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What drug interactions should be considered when using Penicillin G?
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Study Notes
Penicillin G Overview
- No generic name associated with Penicillin G.
- Classified as an antibacterial in therapeutic use.
Pharmacological Classification
- Functions as a cell wall inhibitor and falls under natural penicillin.
Actions and Uses
- Effective against streptococci, pneumococci, and staphylococci that do not produce beta-lactamase.
- Preferred treatment for gonorrhea and syphilis caused by susceptible strains.
- Available as potassium or sodium salt with no therapeutic difference between the two.
- Long-acting forms include penicillin G benzathine (Bicillin) and penicillin G procaine.
- Oral absorption is low (15-30%); primarily administered via IV or IM routes for effectiveness.
- More stable options like penicillin V and amoxicillin are used when oral therapy is preferable.
- Both penicillin G and V inactivated by penicillinase-producing organisms.
Administration Alerts
- Monitor for allergic reactions for 30 minutes post-parenteral administration, particularly after the first dose.
- Avoid mixing penicillin with aminoglycosides in IV solutions; administer these medications 1 hour apart.
- Classified as pregnancy category B, indicating no proven risk in human studies.
Adverse Effects
- Common adverse reactions include diarrhea, nausea, and vomiting, especially risky for children and older adults.
- Injection site pain may occur; risk of superinfections present.
- Serious reaction includes anaphylaxis, with potential late hypersensitivity reactions appearing weeks later.
Contraindications
- Hypersensitivity to penicillin class drugs is the sole contraindication.
- Caution advised in patients with severe renal disease due to extensive renal excretion.
Drug Interactions
- Oral contraceptive effectiveness may be reduced when taken with penicillin G.
- Colestipol can decrease penicillin absorption.
- Co-administration with potassium-sparing diuretics risks hyperkalemia.
- Avoid concurrent use with aminoglycoside antibiotics due to antagonistic effects.
- Penicillin G may yield false results in lab tests, including positive Coombs' test and incorrect urinary or serum protein levels.
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Description
This quiz covers the essential aspects of Penicillin G, including its pharmacological classification, actions, and uses. Learn about its effectiveness against various bacterial infections and important administration alerts. Test your knowledge on the details of this potent antibacterial agent.
