Antipseudomonal and Extended Spectrum Penicillins
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Questions and Answers

What is the primary effect of bacteriostatic antibiotics on microorganisms?

  • They inhibit the growth of bacteria (correct)
  • They kill bacteria directly
  • They enhance the immune system's response
  • They alter the DNA synthesis of bacteria

Which type of antibiotics inhibits the 50S ribosomal subunit?

  • Macrolides
  • Carbapenems
  • Cephalosporins
  • Protein synthesis inhibitors (correct)

What is the mechanism of action of beta-lactam antibiotics?

  • Inhibiting protein synthesis
  • Inhibiting folate metabolism
  • Inhibiting DNA synthesis
  • Inhibiting cell wall synthesis (correct)

Which of the following is an example of a broad-spectrum antibiotic?

<p>Cephalosporins (C)</p> Signup and view all the answers

What is the reason why benzyl penicillin cannot be taken orally?

<p>It is acid-labile (B)</p> Signup and view all the answers

Which of the following penicillins is susceptible to penicillinase and has a narrow spectrum?

<p>Cloxacillin (D)</p> Signup and view all the answers

What is the primary mechanism of action of carbapenems?

<p>Inhibiting cell wall synthesis (B)</p> Signup and view all the answers

What is the mechanism of action of combining penicillins with clavulanic acid or tazobactam?

<p>Inhibition of beta-lactamase (A)</p> Signup and view all the answers

Which of the following penicillins is acid labile and has a spectrum that includes Pseudomonas and some Gram-negative organisms?

<p>Carbenicillin (D)</p> Signup and view all the answers

Which of the following is NOT a use of penicillins?

<p>Treatment of Tuberculosis (C)</p> Signup and view all the answers

What is a common adverse effect of penicillins?

<p>Hypersensitivity reactions (C)</p> Signup and view all the answers

Which of the following penicillins is used to treat Pseudomonas infections?

<p>Ticarcillin (A)</p> Signup and view all the answers

What is the characteristic of cephalosporins that determines their antibacterial spectrum?

<p>Generation of cephalosporin (C)</p> Signup and view all the answers

Which of the following cephalosporins is known to have excellent Gram-negative activity?

<p>Cefipime (C)</p> Signup and view all the answers

What is the characteristic of carbapenems that makes them resistant to β-lactamase?

<p>They are resistant to β-lactamase destruction (A)</p> Signup and view all the answers

Why is imipenem combined with cilastatin?

<p>To prevent its inactivation by renal dihydropeptidase (A)</p> Signup and view all the answers

What is the mechanism of action of carbapenems?

<p>Interference with bacterial cell wall formation (B)</p> Signup and view all the answers

What is the common adverse effect of 3rd generation cephalosporins?

<p>Bleeding (hypoprothrombinemia) (C)</p> Signup and view all the answers

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