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Antipseudomonal and Extended Spectrum Penicillins

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Antipseudomonal and Extended Spectrum Penicillins

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Questions and Answers

What is the primary effect of bacteriostatic antibiotics on microorganisms?

They inhibit the growth of bacteria (correct)

They kill bacteria directly

They enhance the immune system's response

They alter the DNA synthesis of bacteria

Which type of antibiotics inhibits the 50S ribosomal subunit?

Macrolides

Carbapenems

Cephalosporins

Protein synthesis inhibitors (correct)

What is the mechanism of action of beta-lactam antibiotics?

Inhibiting protein synthesis

Inhibiting folate metabolism

Inhibiting DNA synthesis

Inhibiting cell wall synthesis (correct)

Which of the following is an example of a broad-spectrum antibiotic?

Cephalosporins Signup and view all the answers

What is the reason why benzyl penicillin cannot be taken orally?

It is acid-labile Signup and view all the answers

Which of the following penicillins is susceptible to penicillinase and has a narrow spectrum?

Cloxacillin Signup and view all the answers

What is the primary mechanism of action of carbapenems?

Inhibiting cell wall synthesis Signup and view all the answers

What is the mechanism of action of combining penicillins with clavulanic acid or tazobactam?

Inhibition of beta-lactamase Signup and view all the answers

Which of the following penicillins is acid labile and has a spectrum that includes Pseudomonas and some Gram-negative organisms?

Carbenicillin Signup and view all the answers

Which of the following is NOT a use of penicillins?

Treatment of Tuberculosis Signup and view all the answers

What is a common adverse effect of penicillins?

Hypersensitivity reactions Signup and view all the answers

Which of the following penicillins is used to treat Pseudomonas infections?

Ticarcillin Signup and view all the answers

What is the characteristic of cephalosporins that determines their antibacterial spectrum?

Generation of cephalosporin Signup and view all the answers

Which of the following cephalosporins is known to have excellent Gram-negative activity?

Cefipime Signup and view all the answers

What is the characteristic of carbapenems that makes them resistant to β-lactamase?

They are resistant to β-lactamase destruction Signup and view all the answers

Why is imipenem combined with cilastatin?

To prevent its inactivation by renal dihydropeptidase Signup and view all the answers

What is the mechanism of action of carbapenems?

Interference with bacterial cell wall formation Signup and view all the answers

What is the common adverse effect of 3rd generation cephalosporins?

Bleeding (hypoprothrombinemia) Signup and view all the answers