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Pediatrics Review Notes

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10 Questions

In the setting of local anesthetic systemic toxicity (LAST), what may be used intravenously?

Intralipid

Which diabetes medication can cause lactic acidosis in overdose?

Metformin

Acetaminophen overdose can lead to hepatotoxicity due to the formation of NAPQI. Activated charcoal should be given within _____ hours of ingestion.

1-2 hours

Iron overdose can lead to shock or liver failure.

True

Match the following toxic alcohols with their associated antidotes:

Isopropyl alcohol = Supportive care Methanol = Fomepizole or ethanol Ethylene glycol = Fomepizole or ethanol

What are some benefits of breastfeeding to the baby?

Immune protection

Homogenized cow’s milk can be introduced to infants around 9-12 months.

True

What is FPIES, and how is it treated?

FPIES is Food Protein-Induced Enterocolitis Syndrome. It is treated with fluids and ondansetron, while eliminating trigger foods.

Kids exposed to too much screen time may experience early/severe __________.

constipation

Match the following toxidromes with their symptoms and treatment:

Cholinergic Toxidrome = DUMBBELLS symptoms; Atropine, Pralidoxime treatment Anticholinergic Toxidrome = Confusion, hyperthermia, dry mouth symptoms; NaHCO3, Lorazepam treatment Sympathomimetic Toxidrome = Mydriasis, diaphoresis, HTN symptoms; Phentolamine, Lorazepam treatment Opioid Toxidrome = Bradycardia, respiratory depression, pinpoint pupils symptoms; Naloxone treatment

Study Notes

Breastfeeding

  • Benefits to mother: improved postpartum weight loss, delayed onset of menses, decreased breast and ovarian cancer risk, and cost-effectiveness
  • Benefits to baby: immune protection, cognitive development, decreased SIDS risk, and possibly decreased risk of diabetes, atopy, and acute lymphoblastic leukemia/acute myeloid leukemia
  • Composition: 20 kcal/oz (0.67 kcal/mL), high in IgA in colostrum, high in fat in hind milk, and 60:40 whey-to-casein ratio
  • Contraindications: mother with HIV, mother receiving cytotoxic chemotherapy or radiation, infant with galactosemia (PKU is not an absolute contraindication)
  • Recommendations: exclusive breastfeeding until 6 months, with 400 IU/day vitamin D, and continued breastfeeding along with solids until 2 years and beyond

Infant Nutrition

  • First complementary foods should be iron-rich
  • Introduce lumpy textures no later than 9 months to avoid aversions
  • Responsive feeding: cue-based feeding, promote finger feeding, and open cups
  • Cow's milk-based, iron-fortified formula can be introduced around 9-12 months, with a maximum of 750 mL/24 oz daily
  • Avoid honey until 12 months due to botulism risk, and avoid added salt, sugar, and juice
  • Promote healthy eating habits with a regular schedule, and encourage parents to role-model healthy eating
  • For high-risk infants, introduce common allergens (e.g., peanuts, eggs) early (around 4-6 months), in appropriate textures, and maintain for tolerance

Pediatric Growth, Obesity, and Screens

  • Use WHO growth curves
  • BMI categories: overweight (≥85th percentile), obesity (≥97th percentile), and severe obesity (≥99.9th percentile)
  • Obesity management: multi-disciplinary, with a focus on "5-2-1-0" rule (5+ fruits/veggies, ≤2 hours recreational screens, 1+ hour physical activity, and 0 sugar drinks)
  • Optimize sleep

Allergy

  • Non-IgE food allergy (FPIES): profuse vomiting, pallor, lethargy, and hypotension within 1-4 hours of ingestion, with a peak incidence between 2-7 months
  • FPIAP (previously CMPA): intermittent mucous/bloody stools in otherwise well infants, with a strict elimination diet required for both baby and mother
  • Mastocytosis: rare condition with excessive mast cells, presenting with urtication and increased tryptase levels
  • Vaccine allergy: rare, but can occur with large local reactions
  • Allergic rhinitis: generally due to environmental allergies, with treatment involving antihistamines, nasal steroid sprays, and montelukast
  • Pollen-food allergy syndrome: localized IgE-mediated reaction, with no need for an EpiPen
  • Poison Ivy: type IV hypersensitivity reaction, with onset usually within 4-96 hours, and treatment involving high-potency topical steroids
  • Hereditary angioedema: episodic angioedema without itch or urticaria, with a high risk of airway compromise

Toxicology

  • Four main toxidromes: cholinergic, anticholinergic, sympathomimetic, and opioid
  • Cholinergic toxidrome: DUMBBELLS (diaphoresis, urination, miosis, bronchorrhea, bradycardia, emesis, lacrimation, lethargy, salivation)
  • Anticholinergic toxidrome: "mad as a hatter, hot as a hare, blind as a bat, dry as a bone, red as a beet" (confusion, hyperthermia, mydriasis, dry mouth, urinary retention, flushed skin)
  • Sympathomimetic toxidrome: up and wet (mydriasis, diaphoresis, hypertension, tachycardia, hyperthermia, psychosis)
  • Opioid toxidrome: bradycardia, hypotension, respiratory depression, pinpoint pupils, coma
  • Decontamination: activated charcoal, intravenous lipids, and specific antidotes
  • Other toxins and toxicities: hydrocarbons, diabetes medications, acetaminophen, salicylates, iron, and cannabinoids

Burns and Submersion Injuries

  • Submersion injuries: often preventable, with a higher risk in males, particularly in children under 9 years old
  • Burns: superficial partial thickness burns, with a focus on calculating the percentage of total body surface area (TBSA) affected
  • Electrical injuries: high-tension wires can cause extensive damage, with a risk of rhabdomyolysis, CNS injuries, and fatal arrhythmias
  • Inhalational injuries: suspect in the setting of singed nasal hairs, soot in the airway, and hoarseness, with a risk of CO, CN-, and HCl poisoning

Child Maltreatment

  • Risk factors: having a caregiver who is a victim of intimate partner violence, as well as other child-specific, caregiver-specific, and household-specific factors
  • Child maltreatment and adverse childhood experiences (ACEs) predispose to worse health outcomes
  • Physical examination in cases of sexual abuse is often normal or nonspecific
  • Hymenal injuries: hymenal notches can be normal if above 3 and 9 o'clock or below these positions, but without extending to the base of the hymen

Review notes for pediatrics, covering high-yield pearls and information retention tips. Sources include CPRP 2023 and CPS position statements.

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