Pediatrics: Iron Deficiency and Near Miss Events

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Questions and Answers

What is the primary treatment for Primary Biliary Cholangitis (PBC)?

  • Ursodeoxycholic acid (correct)
  • Cholestyramine
  • Steroids
  • Immunosuppressive drugs

Which medication is recommended for treating hyperthyroidism during the first trimester of pregnancy?

  • Methimazole
  • Radioactive iodine
  • Levothyroxine
  • Propylthiouracil (PTU) (correct)

What is the contraindication for administering the HPV vaccine?

  • Age above 26
  • Ongoing chemotherapy
  • Pregnancy (correct)
  • Prior allergic reaction to vaccines

What should be the first line treatment for hypotension after tumor removal?

<p>Normal saline bolus (A)</p> Signup and view all the answers

Which antibiotic is not recommended for treating chlamydia in pregnancy?

<p>Doxycycline (C)</p> Signup and view all the answers

What is the common complication of Primary Biliary Cholangitis (PBC)?

<p>Osteoporosis/osteopenia (A)</p> Signup and view all the answers

Which treatment is recommended for cardiac tachyarrhythmia resulting from increased catecholamine release?

<p>Esmolol (A)</p> Signup and view all the answers

What is the recommended first-line treatment for hepatic hydrothorax?

<p>Sodium restriction and diuretics (A)</p> Signup and view all the answers

What should be done for patients with localized lymphadenopathy after a 3-4 week observation period?

<p>Perform a biopsy to rule out lymphoma (A)</p> Signup and view all the answers

What is the mechanism of EBV exanthema when inappropriate dosages of ampicillin or amoxicillin are given?

<p>Immune-mediated response (B)</p> Signup and view all the answers

Indications for performing a C-section in twin pregnancies include all of the following except:

<p>If presenting twin is underweight (A)</p> Signup and view all the answers

What initial test should be performed in the treatment of pulmonary artery hypertension?

<p>Vasoreactivity test (C)</p> Signup and view all the answers

What treatments are typically used in stroke patients to prevent DVT?

<p>Low-dose heparin or LMWH (A)</p> Signup and view all the answers

What is the most common cause of early death following a stroke?

<p>Pulmonary embolism due to DVT (D)</p> Signup and view all the answers

Which of the following is NOT a contraindication for thrombolytic therapy in cases of ischaemic stroke?

<p>Recent minor surgery (B)</p> Signup and view all the answers

What is typically used in hospitals for managing hyperglycemia in stroke patients?

<p>Insulin (B)</p> Signup and view all the answers

What is the recommended duration for acyclovir/valacyclovir treatment after the onset of symptoms?

<p>7-10 days (B)</p> Signup and view all the answers

What is the primary characteristic distinction between varicella zoster transmission and primary chickenpox infection?

<p>Zoster transmission occurs only through direct contact. (B)</p> Signup and view all the answers

What scoring system is used to predict the necessity of labor induction?

<p>Bishop scoring (D)</p> Signup and view all the answers

Which of the following treatments is NOT commonly used for post-herpetic neuralgia?

<p>Salicylic acid (C)</p> Signup and view all the answers

What is the maximum score possible on the Bishop scoring system?

<p>13 (C)</p> Signup and view all the answers

What is the primary reason for hospitalization in patients with varicella?

<p>Mild varicella in immunocompromised individuals (D)</p> Signup and view all the answers

In which situation is a statin recommended?

<p>For all diabetics aged 40-75 years (D)</p> Signup and view all the answers

Which condition is characterized as neurocardiogenic syncope?

<p>Vasovagal syncope (B)</p> Signup and view all the answers

What is the preferred treatment for Bartonella hensellae infections?

<p>Azithromycin (A)</p> Signup and view all the answers

Which cardiovascular finding is associated with mitral stenosis?

<p>Mid-diastolic rumble (C)</p> Signup and view all the answers

In patients with Ehlers-Danlos syndrome, what skin characteristic is typically observed?

<p>Velvety, dough-like skin (B)</p> Signup and view all the answers

What echocardiographic finding is expected in hypertrophic obstructive cardiomyopathy (HOCM)?

<p>Asymmetric septal hypertrophy (B)</p> Signup and view all the answers

What does the 'pinkish-purplish plaques on the face' in mitral stenosis indicate?

<p>Inadequate perfusion of facial skin (B)</p> Signup and view all the answers

What is the risk categorization of drug class 'C' during pregnancy?

<p>May be safe, but animal studies show risk (A)</p> Signup and view all the answers

What is an expected laboratory finding confirming 21-beta-hydroxylase deficiency?

<p>Increased 17-hydroxyprogesterone levels (C)</p> Signup and view all the answers

What can result from an atrial septal defect (ASD)?

<p>Increased pulmonary blood flow leading to a mid-systolic murmur (C)</p> Signup and view all the answers

What is the recommended management for a patient with mild lead intoxication (5-44 ug/dL)?

<p>Observation and recheck levels in one month (C)</p> Signup and view all the answers

Which of the following indicates a need for carotid endarterectomy in asymptomatic men?

<p>60% stenosis (D)</p> Signup and view all the answers

What first-line treatment is recommended for sulfonylurea poisoning?

<p>Dextrose (C)</p> Signup and view all the answers

In the management of symptomatic peripheral arterial disease, which is the preferred medication?

<p>Cilostazol (B)</p> Signup and view all the answers

What is the next step after conservative treatment with ice for priapism?

<p>Phenylephrine injection (C)</p> Signup and view all the answers

What is the effect of estrogens on thyroid metabolism in patients taking thyroxine?

<p>Increase TBG levels (C)</p> Signup and view all the answers

Which condition necessitates performing an abdominal CT scan regarding varicocele?

<p>Bilateral or right-sided varicocele (D)</p> Signup and view all the answers

In the context of shoulder dystocia, which neurological complication can arise?

<p>Erb Duchenne palsy (C)</p> Signup and view all the answers

What is the primary use of docusate sodium?

<p>To increase stool hydration (A)</p> Signup and view all the answers

At what age is routine Pap screening no longer indicated for women with negative prior screens?

<p>Age 65 (B)</p> Signup and view all the answers

What is the recommended screening for women aged 30-64?

<p>Cytology every 3 years or cytology + HPV testing every 5 years (A)</p> Signup and view all the answers

For women aged 21-24 with atypical squamous cells of undetermined significance (ASCUS), what should be done?

<p>Repeat Pap smear in one year (D)</p> Signup and view all the answers

What should be the next step if a woman is diagnosed with CIN I?

<p>Cytology and colposcopy every 6 months for one year (D)</p> Signup and view all the answers

What defines the screening recommendations difference for women aged 21-29 versus 30-64 regarding HPV?

<p>Transience of HPV infection in younger women (A)</p> Signup and view all the answers

What is NOT a reason for performing colposcopy?

<p>Negative Pap smear results (A)</p> Signup and view all the answers

What is the association of infantile botulism?

<p>Raw honey and environmental dust (D)</p> Signup and view all the answers

Flashcards

Ortner's Syndrome

A condition characterized by hoarseness due to compression of the recurrent laryngeal nerve by an enlarged left atrium.

Noonan Syndrome

Autosomal dominant disorder with features like short stature, facial dysmorphism, and congenital heart defects (most commonly pulmonic stenosis, ASD, hypertrophic cardiomyopathy).

Mitral Facies

Pinkish-purplish plaques found on the face, often associated with mitral stenosis. It is caused by inadequate facial perfusion due to low cardiac output.

Mid-Systolic Murmur associated with ASD

A heart murmur that occurs during the middle of systole (pumping phase) and is often caused by increased blood flow through the pulmonary valve.

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P mitrale

An ECG finding in mitral stenosis characterized by broad and notched P waves, indicating left atrial enlargement.

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Mid-Diastolic Rumble

A heart murmur that occurs in the middle of diastole (relaxation phase) and is a characteristic finding in mitral stenosis. It is caused by turbulent blood flow through the narrowed mitral valve.

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Mycotic Aneurysm

A condition characterized by a weakening and ballooning of an artery, often caused by septic emboli. This leads to an increased risk of rupture and bleeding.

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Mitral Stenosis

A condition characterized by a narrowed mitral valve, leading to increased pressure in the left atrium and symptoms such as fatigue, shortness of breath, and palpitations.

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Shingles (Herpes Zoster)

A condition characterized by painful rash caused by the varicella-zoster virus (VZV). It occurs after a primary chickenpox infection, where the virus remains dormant and can reactivate later in life.

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Acyclovir/Valacyclovir

An antiviral medication prescribed for 7-10 days within 72 hours of symptom onset for the management of shingles.

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Vasovagal Syncope

A type of syncope, often referred to as "fainting", caused by a sudden drop in blood pressure and heart rate due to nerve stimulation.

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Bishop Scoring

A pre-labor scoring system used to predict the likelihood of labor starting spontaneously and to determine if labor induction is necessary.

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Bishop Scoring: Interpretation

A scoring system used to evaluate the readiness of the cervix for labor. A score greater than 9 indicates a high chance of spontaneous labor; a score less than 5 indicates a low probability of spontaneous labor and may require induction.

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SSRI-Associated Sexual Dysfunction

A common side effect of SSRI medications, which can lead to difficulties with sexual desire, arousal, and/or performance.

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Neurogenic Syncope

A type of syncope caused by a sudden disruption in the blood supply to the brain, often due to atherosclerosis.

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Cardiogenic Syncope

A type of syncope caused by problems with the heart, such as arrhythmias or obstructions like aortic stenosis (AS) or hypertrophic obstructive cardiomyopathy (HOCM).

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Sydenham Chorea

A condition that develops 1-8 months after a Group A Strep infection, characterized by involuntary movements, primarily affecting the face, limbs, and trunk. It typically resolves spontaneously but can be treated with penicillin to eliminate the bacteria.

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Rheumatic Carditis

Inflammation of the heart, often a complication of rheumatic fever, affecting the endocardium, myocardium, or pericardium. It can lead to heart failure, valvular heart disease, and cardiac arrhythmias.

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Hepatic Hydrothorax

A condition where fluid accumulates in the pleural space surrounding the lungs due to increased pressure in the portal vein, a consequence of liver disease.

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Vasoreactivity Test

A test used to assess the response of pulmonary artery pressure to a vasodilator, helping to determine the effectiveness of calcium channel blockers in treating pulmonary hypertension.

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Pulmonary Artery Hypertension

A condition characterized by high blood pressure in the pulmonary arteries, often leading to right heart failure. It can be triggered by a variety of factors, including congenital heart defects and chronic lung diseases.

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Localized Lymphadenopathy

An inflammation of the lymphatic system, often seen as enlarged lymph nodes, particularly in the neck, during mononucleosis.

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Pulmonary Embolism

A serious condition characterized by a blood clot in the lungs, often a complication of deep vein thrombosis (DVT), especially after a stroke.

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Dysphagia

A common complication of stroke, affecting swallowing ability, leading to choking, aspiration, and potential pneumonia.

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What is the primary liver function abnormality in Primary Biliary Cholangitis (PBC)?

A condition characterized by elevated liver enzymes and elevated alkaline phosphatase, but normal bilirubin levels.

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How is Primary Biliary Cholangitis (PBC) treated?

Ursodeoxycholic acid (UDCA) and liver transplantation are the primary treatment methods for PBC.

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How is hyperthyroidism managed during pregnancy?

During the first trimester of pregnancy, propylthiouracil (PTU) is the preferred treatment for hyperthyroidism. However, during the second and third trimesters, methimazole is generally used due to the potential for PTU to cause liver failure.

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Who should receive the HPV vaccine and what is the main contraindication?

The HPV vaccine is recommended for individuals between the ages of 11 and 26, with three doses given over a 6-month period. The only contraindication is pregnancy.

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What is palivizumab used for?

Palivizumab is a monoclonal antibody used to prevent respiratory syncytial virus (RSV) infection in high-risk infants, particularly those born prematurely.

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What are the potential complications and treatment for hypotension after adrenalectomy?

Following adrenalectomy, patients may experience hypotension due to decreased catecholamine production. Treatment typically involves intravenous fluid resuscitation with normal saline, followed by pressors if needed.

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What are the potential complications and treatment for hypoglycemia after adrenalectomy?

Following adrenalectomy, patients may experience hypoglycemia due to increased insulin secretion. Treatment involves intravenous dextrose infusion.

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How is Chlamydia trachomatus managed in pregnant women?

Chlamydia trachomatus is a sexually transmitted infection that should be screened for in pregnant women, especially those at high risk, in both the first and third trimesters. Erythromycin base or amoxicillin are recommended treatments during pregnancy.

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Docusate Sodium: Stool Softener

Docusate sodium is a medication that helps soften stools by increasing water content. It is less effective than other laxatives for long-term constipation but can be useful for post-surgery patients to prevent straining.

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Pap Smear Guidelines

Pap smears are used to screen for cervical cancer. The frequency of screening changes based on age and risk factors.

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Pap Smear: Age 21 - 29

Women under 21 do not need Pap smears. Women 21-29 should have a Pap smear every 3 years.

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Pap Smear: Age 30 - 64

Women 30-64 can choose between Pap smears every 3 years or combined Pap + HPV testing every 5 years.

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Pap Smear: Age 65+

Women over 65 who have had negative Pap smears and are not high-risk do not need routine screening.

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Pap Smear: Hysterectomy

Women who have had a hysterectomy, including removal of the cervix, do not need screening unless they are high-risk.

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ASCUS: Pap Smear Result

Atypical squamous cells of undetermined significance (ASCUS) are abnormal cells on a Pap smear that may be precancerous. Management depends on age and HPV testing results.

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Infantile Botulism

Infantile botulism is a serious illness caused by ingesting spores of the bacterium Clostridium botulinum. The spores can be found in honey and dust.

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Lead Poisoning Treatment

Lead poisoning is treated according to the blood lead level. Mild cases (5-44 ug/dL) don't require medication, while moderate (45-69) cases are treated with oral succimer. Severe cases (70+ ug/dL) require a combination of IM dimercaprol and IV EDTA.

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When to Order Abdominal CT for Varicocele

An abdominal CT scan is recommended for patients with bilateral or right-sided varicocele, or a varicocele that doesn't disappear when lying down. This helps identify potential causes of obstruction, such as a tumor or blood clot.

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Carotid Endarterectomy Indications

Carotid endarterectomy is a surgical procedure to remove plaque buildup in the carotid artery. The criteria for performing this surgery depend on the degree of stenosis and the patient's symptoms.

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Drug Effects on Thyroid Metabolism

Certain drugs can impact thyroid metabolism by altering thyroid-binding globulin (TBG) levels. Estrogens, SERMs, methadone, and heroin increase TBG, requiring increased thyroxine dosages. Androgens, danazol, anabolic steroids, and glucocorticoids decrease TBG, requiring decreased thyroxine dosages.

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Fungal Endophthalmitis Treatment

Fungal endophthalmitis, often caused by Candida, requires prompt treatment with vitrectomy and either amphotericin B or fluconazole.

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Sulfonylurea Poisoning Treatment

Sulfonylurea poisoning is treated with dextrose as the first-line therapy. Octreotide, a somatostatin analogue, can help reduce insulin secretion triggered by sulfonylureas.

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Peripheral Arterial Disease (PAD) Management

Peripheral artery disease (PAD) management involves controlling risk factors, regular exercise, and medication. Cilostazol is the preferred medication over pentoxifylline. Surgery is indicated for limb-threatening conditions or persistent functional impairments.

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Normal Caloric Stimulation Response in Psychogenic Coma

Normal caloric stimulation of the external ear canal triggers a specific eye movement pattern. This response, involving a transient deviation towards the stimulus and corrective saccadic movement, strongly suggests a psychogenic coma.

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Study Notes

Iron Deficiency in Infants

  • Iron deficiency in infants is often due to supplementation with cow/goat/soy milk under the age of 1, or exclusively breastfeeding after 6 months.
  • Perform a full blood count (FBC) and administer oral iron supplementation if anaemia is present.
  • Reticulocyte count increases first, followed by haemoglobin and haematocrit levels.

Near-Miss Events

  • Report medical errors that are caught before reaching the patient to hospital administration.
  • Reporting near misses to the patient is not mandatory, only errors that have occurred.

Caput Succedaneum vs Cephalohematoma

  • Caput succedaneum crosses suture lines. Cephalohematoma does not.
  • Caput succedaneum is often ecchymotic and resolves on its own within weeks.
  • Cephalohaematoma is associated with underlying skull fractures in 10-25 % of cases; it is not visible for several hours.
  • It resolves in two weeks to three months. Neither condition requires treatment.

Mammograms and Ultrasound

  • Mammograms should be performed every two years between the ages of 50 and 75.
  • An ultrasound should be performed alone on patients under the age of 30.
  • For patients over 30, both a mammogram and ultrasound should be performed.

Digoxin Toxicity

  • Verapamil, quinidine, amiodarone, and spironolactone can all cause digoxin toxicity.

Bezold Abscess

  • A Bezold abscess is a neck abscess that develops as a result of the spread of mastoiditis in the neck.
  • It usually presents in the sternocleidomastoid muscle.

Hepatitis C

  • In patients with a positive ELISA test for Hepatitis C, a confirmatory test for HCV RNA is the next best step.
  • This test can distinguish between persistent, resolved, and false-positive infections.

Type 1 Diabetes Mellitus

  • A child has a 3% risk of developing type 1 diabetes if only the mother has it; and a 6% risk if only the father has it.
  • Identical twins have a 50% risk of developing type 1 diabetes.

Apnea Testing

  • Apnea testing can be used to confirm brain death in patients with absent cortical and brainstem reflexes.

Herbs Associated with Increased Bleeding Risk

  • Ginkgo biloba, ginseng, saw palmetto (likely platelet dysfunction), black cohosh, and garlic, and horse chestnut,

Herbs Associated with Hepatotoxicity

  • Black Cohosh, Kava Kava

Malignant Otitis Externa

  • Tx of malignant otitis externa requires intravenous anti-pseudomonals (e.g., ciprofloxacin) initially followed by oral therapy for 6-8 weeks.

Hypoglycaemia

  • If low blood sugar is suspected and serum insulin and C-peptide both elevated, an oral hypoglycaemic serum screen (e.g., sulfonylurea levels) should be performed.
  • In this case, insulinoma is not the only likely diagnosis.

Restless Legs Syndrome

  • Restless leg syndrome can be caused by iron deficiency.
  • Ferritin should be measured in patients with restless legs syndrome, as iron deficiency can be present in the absence of anaemia.
  • It can also be caused by chronic renal failure, uraemia, diabetes, pregnancy, and several drugs (e.g., some antidepressants).

Peripartum Cardiomyopathy

  • A transthoracic echocardiograph can evaluate the risk of future peripartum cardiomyopathy in patients with a history of decreased EF

Breast Abscess

  • If suspected breast abscess (secondary to mastitis), an initial ultrasound is necessary to confirm diagnosis before considering needle aspiration or incision and drainage.

HIV Post-Exposure Prophylaxis

  • Post-exposure prophylaxis for HIV usually involves two NRTIs + one of the following: NNRTI, integrase inhibitor, or protease inhibitor for a period of four weeks

Hypercalcaemia

  • Excess calcium can cause anxiety, depression, weakness, constipation, peptic ulcer diseases and/or diastolic hypertension.

Hypocalcaemia

  • Hypocalcaemia may cause hyperpigmentation, seizures, and hypotension.

Kidney Injury

  • Monitor fluid status (e.g., IV fluids) closely in patients with kidney injury (Acute Tubular Necrosis-ATN) to prevent pulmonary edema and hyperchloraemic metabolic acidosis.

Otitis Externa

  • Intravenous anti-pseudomonals (e.g., ciprofloxacin) followed by oral antibiotics is the common treatment for malignant otitis externa

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