18 Questions
What is the primary function of checkpoint proteins in the immune system?
To distinguish between foreign cells and normal cells
What is the result of PD-1 binding with its ligands, PD-L1 and PD-L2?
T-cell inactivation and cytokine suppression
Which protein found on the surface of T cells binds to PD-L1 to block T-cell activity?
CD80
What is the mechanism by which cancer cells can survive in the presence of an immune system?
By tricking the immune system into not attacking it
What is the role of PD-1 in the adaptive immune response?
To prevent T-cell proliferation and cytokine production
What is the outcome of immune checkpoint inhibitors in cancer treatment?
Restored immune response against cancer cells
What is the primary function of PD-L1 in tumor cells?
To inhibit T cells from killing tumor cells
What is the mechanism of action of PD-1 inhibitors?
Preventing the binding of PD-L1 and PD-L2 to PD-1 receptors
What is the result of interrupting the PD-1/PD-L1 pathway?
The immune system recognizes and attacks tumor cells
What is the role of PD-1 receptors on T cells?
To inhibit the activity of T cells
What is the primary mechanism of action of PD-L1 inhibitors in cancer treatment?
Preventing the interaction between PD-L1 and PD-1 on the surface of T cells
What is the outcome of PD-1 inhibition on tumor cells?
Tumor cells are recognized and attacked by T cells
What is the function of CD80 in the PD-1/PD-L1 pathway?
To recognize and bind to T-cell receptors
What is the outcome of PD-L1 inhibition on tumor cells?
Tumor cell death and apoptosis
Which of the following is NOT a characteristic of PD-L1 inhibitors?
They are small molecule inhibitors
What is the role of CD80 in the mechanism of action of PD-L1 inhibitors?
It is a ligand that binds to PD-1 on the surface of T cells
Which two PD-L1 inhibitors are currently undergoing clinical testing for endometrial cancer?
Durvalumab and atezolizumab
What is the outcome of blocking the PD-L1 pathway on T cell activity?
Increased T cell activity and cytotoxicity
Test your knowledge on PD-1 and PD-L1 inhibitors, their role in cancer treatment, and the latest developments in the field. This quiz is designed for internal use only and covers key concepts and products related to oncology. Review your understanding of these important inhibitors and their applications.
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