Podcast
Questions and Answers
What is the primary function of checkpoint proteins in the immune system?
What is the primary function of checkpoint proteins in the immune system?
- To stimulate an immune response against normal cells
- To distinguish between foreign cells and normal cells (correct)
- To activate T-cell proliferation and cytokine production
- To promote the survival of cancer cells
What is the result of PD-1 binding with its ligands, PD-L1 and PD-L2?
What is the result of PD-1 binding with its ligands, PD-L1 and PD-L2?
- T-cell inactivation and cytokine suppression (correct)
- T-cell activation and cytokine production
- Induction of apoptosis in cancer cells
- Enhanced immune response against foreign cells
Which protein found on the surface of T cells binds to PD-L1 to block T-cell activity?
Which protein found on the surface of T cells binds to PD-L1 to block T-cell activity?
- PD-1
- CD80 (correct)
- CD28
- CTLA-4
What is the mechanism by which cancer cells can survive in the presence of an immune system?
What is the mechanism by which cancer cells can survive in the presence of an immune system?
What is the role of PD-1 in the adaptive immune response?
What is the role of PD-1 in the adaptive immune response?
What is the outcome of immune checkpoint inhibitors in cancer treatment?
What is the outcome of immune checkpoint inhibitors in cancer treatment?
What is the primary function of PD-L1 in tumor cells?
What is the primary function of PD-L1 in tumor cells?
What is the mechanism of action of PD-1 inhibitors?
What is the mechanism of action of PD-1 inhibitors?
What is the result of interrupting the PD-1/PD-L1 pathway?
What is the result of interrupting the PD-1/PD-L1 pathway?
What is the role of PD-1 receptors on T cells?
What is the role of PD-1 receptors on T cells?
What is the primary mechanism of action of PD-L1 inhibitors in cancer treatment?
What is the primary mechanism of action of PD-L1 inhibitors in cancer treatment?
What is the outcome of PD-1 inhibition on tumor cells?
What is the outcome of PD-1 inhibition on tumor cells?
What is the function of CD80 in the PD-1/PD-L1 pathway?
What is the function of CD80 in the PD-1/PD-L1 pathway?
What is the outcome of PD-L1 inhibition on tumor cells?
What is the outcome of PD-L1 inhibition on tumor cells?
Which of the following is NOT a characteristic of PD-L1 inhibitors?
Which of the following is NOT a characteristic of PD-L1 inhibitors?
What is the role of CD80 in the mechanism of action of PD-L1 inhibitors?
What is the role of CD80 in the mechanism of action of PD-L1 inhibitors?
Which two PD-L1 inhibitors are currently undergoing clinical testing for endometrial cancer?
Which two PD-L1 inhibitors are currently undergoing clinical testing for endometrial cancer?
What is the outcome of blocking the PD-L1 pathway on T cell activity?
What is the outcome of blocking the PD-L1 pathway on T cell activity?
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