PD-1 and PD-L1 Inhibitors in Oncology
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Questions and Answers

What is the primary function of checkpoint proteins in the immune system?

  • To stimulate an immune response against normal cells
  • To distinguish between foreign cells and normal cells (correct)
  • To activate T-cell proliferation and cytokine production
  • To promote the survival of cancer cells
  • What is the result of PD-1 binding with its ligands, PD-L1 and PD-L2?

  • T-cell inactivation and cytokine suppression (correct)
  • T-cell activation and cytokine production
  • Induction of apoptosis in cancer cells
  • Enhanced immune response against foreign cells
  • Which protein found on the surface of T cells binds to PD-L1 to block T-cell activity?

  • PD-1
  • CD80 (correct)
  • CD28
  • CTLA-4
  • What is the mechanism by which cancer cells can survive in the presence of an immune system?

    <p>By tricking the immune system into not attacking it</p> Signup and view all the answers

    What is the role of PD-1 in the adaptive immune response?

    <p>To prevent T-cell proliferation and cytokine production</p> Signup and view all the answers

    What is the outcome of immune checkpoint inhibitors in cancer treatment?

    <p>Restored immune response against cancer cells</p> Signup and view all the answers

    What is the primary function of PD-L1 in tumor cells?

    <p>To inhibit T cells from killing tumor cells</p> Signup and view all the answers

    What is the mechanism of action of PD-1 inhibitors?

    <p>Preventing the binding of PD-L1 and PD-L2 to PD-1 receptors</p> Signup and view all the answers

    What is the result of interrupting the PD-1/PD-L1 pathway?

    <p>The immune system recognizes and attacks tumor cells</p> Signup and view all the answers

    What is the role of PD-1 receptors on T cells?

    <p>To inhibit the activity of T cells</p> Signup and view all the answers

    What is the primary mechanism of action of PD-L1 inhibitors in cancer treatment?

    <p>Preventing the interaction between PD-L1 and PD-1 on the surface of T cells</p> Signup and view all the answers

    What is the outcome of PD-1 inhibition on tumor cells?

    <p>Tumor cells are recognized and attacked by T cells</p> Signup and view all the answers

    What is the function of CD80 in the PD-1/PD-L1 pathway?

    <p>To recognize and bind to T-cell receptors</p> Signup and view all the answers

    What is the outcome of PD-L1 inhibition on tumor cells?

    <p>Tumor cell death and apoptosis</p> Signup and view all the answers

    Which of the following is NOT a characteristic of PD-L1 inhibitors?

    <p>They are small molecule inhibitors</p> Signup and view all the answers

    What is the role of CD80 in the mechanism of action of PD-L1 inhibitors?

    <p>It is a ligand that binds to PD-1 on the surface of T cells</p> Signup and view all the answers

    Which two PD-L1 inhibitors are currently undergoing clinical testing for endometrial cancer?

    <p>Durvalumab and atezolizumab</p> Signup and view all the answers

    What is the outcome of blocking the PD-L1 pathway on T cell activity?

    <p>Increased T cell activity and cytotoxicity</p> Signup and view all the answers

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