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Questions and Answers
How does inclisiran reduce LDL-C levels?
How does inclisiran reduce LDL-C levels?
- By targeting PCSK9 mRNA with an siRNA (correct)
- By promoting PCSK9 binding to the LDLR
- By blocking PCSK9 production at the translational stage
- By inhibiting PCSK9 auto-catalytic processing
Which phase of PCSK9's life cycle is targeted by inclisiran?
Which phase of PCSK9's life cycle is targeted by inclisiran?
- Inhibition of LDLR binding
- Inhibition of PCSK9 production (correct)
- Inhibition of auto-catalytic processing
- All of the above
What is the main effect of stopping PCSK9 auto-catalytic processing?
What is the main effect of stopping PCSK9 auto-catalytic processing?
- Reduction in PCSK9 plasma concentrations
- Lowering risk of cardiovascular disease
- Increased cell secretion and maturation
- Elevated LDL-C levels (correct)
Which method frees up more receptors to be recycled to the cell surface for LDL-C elimination?
Which method frees up more receptors to be recycled to the cell surface for LDL-C elimination?
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What is the primary role of inclisiran in individuals with primary hypercholesterolemia?
What is the primary role of inclisiran in individuals with primary hypercholesterolemia?
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What distinguishes inclisiran's mechanism of action from other PCSK9 inhibitors?
What distinguishes inclisiran's mechanism of action from other PCSK9 inhibitors?
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