PCSK9 Inhibition Methods Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson
Download our mobile app to listen on the go
Get App

Questions and Answers

How does inclisiran reduce LDL-C levels?

  • By targeting PCSK9 mRNA with an siRNA (correct)
  • By promoting PCSK9 binding to the LDLR
  • By blocking PCSK9 production at the translational stage
  • By inhibiting PCSK9 auto-catalytic processing

Which phase of PCSK9's life cycle is targeted by inclisiran?

  • Inhibition of LDLR binding
  • Inhibition of PCSK9 production (correct)
  • Inhibition of auto-catalytic processing
  • All of the above

What is the main effect of stopping PCSK9 auto-catalytic processing?

  • Reduction in PCSK9 plasma concentrations
  • Lowering risk of cardiovascular disease
  • Increased cell secretion and maturation
  • Elevated LDL-C levels (correct)

Which method frees up more receptors to be recycled to the cell surface for LDL-C elimination?

<p>Inhibition of LDLR binding (D)</p> Signup and view all the answers

What is the primary role of inclisiran in individuals with primary hypercholesterolemia?

<p>Decrease PCSK9 plasma concentrations (A)</p> Signup and view all the answers

What distinguishes inclisiran's mechanism of action from other PCSK9 inhibitors?

<p>Targets PCSK9 mRNA with siRNA (D)</p> Signup and view all the answers

Flashcards are hidden until you start studying

More Like This

Repatha Flashcards
14 questions

Repatha Flashcards

DetachableHydra avatar
DetachableHydra
Test 14
20 questions

Test 14

AstoundingCarnelian5257 avatar
AstoundingCarnelian5257
PCSK9 Inhibitors: Evolocumab and Alirocumab
10 questions
Use Quizgecko on...
Browser
Browser