6 Questions
How does inclisiran reduce LDL-C levels?
By targeting PCSK9 mRNA with an siRNA
Which phase of PCSK9's life cycle is targeted by inclisiran?
Inhibition of PCSK9 production
What is the main effect of stopping PCSK9 auto-catalytic processing?
Elevated LDL-C levels
Which method frees up more receptors to be recycled to the cell surface for LDL-C elimination?
Inhibition of LDLR binding
What is the primary role of inclisiran in individuals with primary hypercholesterolemia?
Decrease PCSK9 plasma concentrations
What distinguishes inclisiran's mechanism of action from other PCSK9 inhibitors?
Targets PCSK9 mRNA with siRNA
Test your knowledge on the different categories of PCSK9 inhibitors, including inhibition of LDLR binding, inhibition of PCSK9 production, and inhibition of auto-catalytic processing. Learn how PCSK9 inhibitors can impact LDL- C elimination and the synthesis of PCSK9 gene.
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