Questions and Answers
What is the generic name of Repatha?
What significant effect does Repatha have on LDL levels?
It effectively brings about LDL reduction.
Repatha's clinical trials indicated that it lowered LDL regardless of the different statins used.
True
Who is indicated to use Repatha?
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What are some common side effects of Repatha?
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What is the recommended subcutaneous dosage for Repatha?
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What does the SureClick® autoinjector do?
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How does Repatha work?
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Repatha has a potential for immunogenicity.
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What support services do RepathaReady® nurses provide?
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What is the maximum amount eligible patients pay with the Repatha® Copay Card?
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What assistance does Repatha offer related to insurance?
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How does Repatha help the liver manage LDL?
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Repatha is used in addition to statin drugs.
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Study Notes
Repatha Overview
- Repatha is the brand name for evolocumab, classified as a PCSK9 inhibitor.
Efficacy
- LDL reduction effects begin to manifest within the first two weeks of treatment with Repatha.
Clinical Trials
- Demonstrated consistent LDL lowering in studies regardless of the concurrent statin used.
Indications
- Prescribed for individuals with plaque-related cardiovascular issues needing LDL reduction in conjunction with diet and statin therapy.
Side Effects
- Common adverse reactions include runny nose, sore throat, flu-like symptoms, back pain, and injection site discomfort.
Dosing Information
- Recommended dosages include either 140 mg every two weeks or 420 mg once monthly for patients with HeFH or primary hyperlipidemia with established cardiovascular disease.
Administration Methods
- SureClick® autoinjector: 15-second self-injection every two weeks.
- Pushtronex® system: 9-minute hands-free injection administered once a month.
Pen Features
- SureClick: Auditory cues for dosage start and finish, hidden needle for safety, injection options for stomach, thigh, or arm with assistance.
- PushTronex: Similar features to SureClick with added auditory and visual cues for dosage administration.
Mechanism of Action
- Lowers LDL-C levels by inhibiting PCSK9 binding to LDL receptors, increasing receptor availability to clear LDL from the bloodstream.
Adverse Reactions
- Immunogenicity is a potential risk due to its nature as a human monoclonal antibody.
Nurse Support
- RepathaReady® nurses provide personalized support, including injection training and copay assistance, available in multiple languages.
Savings Card
- Eligible patients can use the Repatha® Copay Card to reduce costs to no more than $5.
Coverage Assistance
- Repatha provides insurance assistance options for better accessibility.
Mechanism Clarification
- Repatha facilitates liver clearance of LDL by reducing PCSK9 activity, which correlates to decreased LDL levels in blood.
Add-On Therapy
- Can be used in conjunction with statin medications for enhanced therapeutic effect.
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Test your knowledge of Repatha, a PCSK9 inhibitor, through these flashcards. Explore its efficacy, clinical trials, and generic name. Perfect for students or professionals in the pharmaceutical field!
