Pathology Reversible and Irreversible Cell Injury Quiz
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Questions and Answers

What enzyme deficiency is most likely causing the patient's symptoms?

  • Hypoxanthine-guanine phosphoribosyltransferase
  • Homogentisic oxidase (correct)
  • Ketoacid decarboxylase
  • L-Iduronosulfate sulfatase
  • What was the reason for the missed diagnosis of PKU at birth?

  • Cord blood is not a good source of fetal blood.
  • The test should have been performed on urine rather than blood
  • The screening (Guthrie) test has low sensitivity. (correct)
  • The test should have been performed on maternal blood.
  • Which of the following types of inflammatory cells is most likely a prominent feature of the exudate in the patient's lung?

  • Lymphocytes
  • Neutrophils (correct)
  • Basophils
  • Eosinophils
  • Monocytes-macrophages
  • What is the key difference between metastatic calcification and dystrophic calcification?

    <p>Serum calcium concentration</p> Signup and view all the answers

    Which of the following are signs of reversible injury?

    <p>Mitochondrial swelling</p> Signup and view all the answers

    What is the likely diagnosis based on the complete blood count finding in the 22-year-old medical student?

    <p>Leukocytosis</p> Signup and view all the answers

    What protein is the gene product of Her-2/neu?

    <p>Receptor tyrosine kinase</p> Signup and view all the answers

    Which type of tumor has been diagnosed in the 27-year-old woman?

    <p>Glioma</p> Signup and view all the answers

    What does the pediatrician note on the 8-year-old child's torso?

    <p>Café-au-lait spots</p> Signup and view all the answers

    Study Notes

    Enzyme Deficiency

    • The patient's symptoms are likely caused by a deficiency in phenylalanine hydroxylase.

    Missed Diagnosis of PKU

    • The reason for missing PKU diagnosis at birth could be due to lack of newborn screening.

    Inflammatory Cell Type

    • Eosinophils are likely prominent in the lung exudate.

    Key Difference Between Calcification Types

    • Metastatic calcification occurs in normal tissues due to hypercalcemia, while dystrophic calcification happens in injured or necrotic tissues regardless of calcium levels.

    Signs of Reversible Injury

    • Cellular swelling, fatty change, and mitochondrial swelling are signs of reversible cell injury.

    Likely Diagnosis Based on CBC

    • The medical student's CBC likely shows signs of infectious mononucleosis.

    Her-2/Neu Gene Product

    • The Her-2/neu gene produces a transmembrane receptor tyrosine kinase protein.

    Tumor Type Diagnosed

    • The 27-year-old woman has been diagnosed with Invasive Ductal Carcinoma (IDC).

    Physical Examination Findings

    • The pediatrician notes a café au lait macule on the 8-year-old child's torso.

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    Description

    Test your knowledge of reversible and irreversible cell injury in pathology with this quiz. The quiz covers topics such as metastatic calcification, dystrophic calcification, reversible injury signs like myelin figures and cell blebs, and irreversible injury signs like nuclear changes.

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