Podcast
Questions and Answers
What are the main parts of the stomach?
What are the main parts of the stomach?
Cardia, Fundus, Body, Antrum
Which cells dominate the cardia region of the stomach?
Which cells dominate the cardia region of the stomach?
- Mucin secreting foveolar cells (correct)
- Chief cells
- Neuroendocrine G cells
- Parietal cells
Acute gastritis and gastropathy are the same condition.
Acute gastritis and gastropathy are the same condition.
False (B)
What is the most common cause of acute gastritis?
What is the most common cause of acute gastritis?
Acute gastritis is characterized by the presence of ______.
Acute gastritis is characterized by the presence of ______.
What are the clinical features of severe acute gastritis?
What are the clinical features of severe acute gastritis?
Which protective mechanism helps prevent gastric acidity from damaging the stomach lining?
Which protective mechanism helps prevent gastric acidity from damaging the stomach lining?
List two injurious stimuli that can lead to gastritis.
List two injurious stimuli that can lead to gastritis.
Flashcards
Cardia Function
Cardia Function
Protects stomach lining via mucin secretion.
Parietal and Chief Cells
Parietal and Chief Cells
Secrete HCl and pepsin, respectively.
Antrum G Cells
Antrum G Cells
Stimulate parietal cells to produce acid.
Acute Gastritis
Acute Gastritis
Signup and view all the flashcards
Gastropathy
Gastropathy
Signup and view all the flashcards
Acute Gastritis Symptoms
Acute Gastritis Symptoms
Signup and view all the flashcards
Protective Stomach Mechanisms
Protective Stomach Mechanisms
Signup and view all the flashcards
Injurious Stimuli to Stomach
Injurious Stimuli to Stomach
Signup and view all the flashcards
Study Notes
Overview of Gastric Diseases
- Includes acute gastritis, chronic gastritis, acute gastric ulcer, and chronic peptic ulcers.
- Understanding normal anatomy and histology is essential before discussing pathology.
Normal Anatomy & Histology of the Stomach
- Four main parts: cardia, fundus, body, and antrum (pylorus).
- Cardia: Features mucin-secreting foveolar cells that protect the stomach lining.
- Body and Fundus: Contains parietal cells (secrete HCl) and chief cells (secrete pepsin).
- Antrum: Houses neuroendocrine G cells that stimulate parietal cells to produce acid.
Histological Features
- Histology varies across stomach regions; thickness differs as well.
- In H&E stain, parietal cells appear pink due to acid production.
- The antrum appears bluish with antrum-type epithelium lacking parietal cells.
Inflammatory Conditions of the Stomach
- Acute gastritis and gastropathy often used interchangeably; both involve mucosal injury.
- Acute Gastritis: Characterized by neutrophilic infiltration.
- Gastropathy: Damage and regeneration with minimal to no inflammation; often related to NSAIDs and stress.
Causes and Clinical Features of Acute Gastritis
- NSAIDs are the primary cause; symptoms may remain asymptomatic or present as:
- Epigastric pain
- Nausea and vomiting
- Severe cases may lead to erosions, ulcers, hematemesis, and melena.
Pathogenesis of Gastritis
- Similar mechanisms underlie acute and chronic gastritis.
- Protective mechanisms counteract damaging factors like HCl and peptic enzymes:
- Surface mucus secretion forms a barrier against acidity.
- Bicarbonate maintains alkaline pH to protect the stomach lining.
- Profuse mucosal blood flow aids in rapid regeneration of gastric mucosa and buffers acidity.
- Epithelial regenerative capacity and prostaglandin synthesis play vital roles.
Injurious Stimuli Leading to Gastritis
- Common injurious factors include:
- Helicobacter pylori infection
- Use of NSAIDs and aspirin (reduce prostaglandin levels)
- Tobacco and smoking
- Alcohol consumption
- Conditions causing gastric hyperacidity.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.