10 Questions
What type of foreign bodies initiate foreign body granuloma?
Inert foreign bodies such as talc, sutures, fibers, etc.
What is the primary cell responsible for initiating foreign body granuloma?
Macrophage
What is the characteristic of foreign bodies that leads to granuloma formation?
They are large enough to preclude phagocytosis by a single macrophage.
What is the term for the type of granulomatous inflammation caused by inert foreign bodies?
Foreign body granuloma
What is the main difference between foreign body granuloma and other types of granulomatous inflammation?
The lack of an immune response to the foreign body.
What is the role of macrophages in granuloma formation?
Macrophages aggregate and fuse to form a multinucleated giant cell, which then surrounds the foreign body.
What is the term for the formation of a granuloma in response to a foreign body?
Granulomatous inflammation
What is the primary function of a granuloma?
To contain and isolate the foreign body or pathogen.
What is the characteristic of chronic inflammation that leads to granuloma formation?
The persistence of the foreign body or pathogen.
What is the term for the type of granulomatous inflammation caused by a persistent pathogen?
Immune-mediated granulomatous inflammation.
Test your knowledge on the progression of sarcoidosis, from the deposition of collagen to mature fibrosis, and the causes of granulomatous inflammation. Learn about the role of CD4 T cells, cytokines, and antigen presentation in granuloma formation. Identify the major bacterial and fungal causes of granulomatous inflammation.
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