Pathology of Sarcoidosis and Granulomatous Inflammation
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Questions and Answers

What type of foreign bodies initiate foreign body granuloma?

Inert foreign bodies such as talc, sutures, fibers, etc.

What is the primary cell responsible for initiating foreign body granuloma?

Macrophage

What is the characteristic of foreign bodies that leads to granuloma formation?

They are large enough to preclude phagocytosis by a single macrophage.

What is the term for the type of granulomatous inflammation caused by inert foreign bodies?

<p>Foreign body granuloma</p> Signup and view all the answers

What is the main difference between foreign body granuloma and other types of granulomatous inflammation?

<p>The lack of an immune response to the foreign body.</p> Signup and view all the answers

What is the role of macrophages in granuloma formation?

<p>Macrophages aggregate and fuse to form a multinucleated giant cell, which then surrounds the foreign body.</p> Signup and view all the answers

What is the term for the formation of a granuloma in response to a foreign body?

<p>Granulomatous inflammation</p> Signup and view all the answers

What is the primary function of a granuloma?

<p>To contain and isolate the foreign body or pathogen.</p> Signup and view all the answers

What is the characteristic of chronic inflammation that leads to granuloma formation?

<p>The persistence of the foreign body or pathogen.</p> Signup and view all the answers

What is the term for the type of granulomatous inflammation caused by a persistent pathogen?

<p>Immune-mediated granulomatous inflammation.</p> Signup and view all the answers

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