Pathology of Inflammatory Polyps

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What is the primary cause of tufting on the polyp surface?

Inflammatory response
Chronic constipation
Mucosal prolapse
Epithelial overcrowding (correct)

What is the characteristic feature of the epithelial cells on the polyp surface?

Irregular tufting (correct)
Complete absence
Regular tufting
Uniform layering

What is the characteristic architectural feature of crypts cut in cross-section in hyperplastic polyps?

Proliferative architecture
Serrated architecture (correct)
Fibrous architecture
Glandular architecture

What is the primary cause of inflammatory polyp formation?

Chronic cycles of injury and healing (D) Signup and view all the answers

What is a characteristic histological feature of inflammatory polyps?

Mixed inflammatory infiltrates (C) Signup and view all the answers

What is the indication of mucosal prolapse in inflammatory polyps?

Smooth muscle hyperplasia within the lamina propria (D) Signup and view all the answers

What is the average age of onset for Peutz-Jeghers syndrome?

11 years (C) Signup and view all the answers

What is the lifetime risk of malignancies associated with Peutz-Jeghers syndrome?

40% (D) Signup and view all the answers

What is the characteristic feature of Peutz-Jeghers polyps under histology?

Complex glandular architecture (B) Signup and view all the answers

What is the recommended surveillance for individuals with Peutz-Jeghers syndrome?

Regular surveillance at various stages of life (B) Signup and view all the answers

What is the most common location of Peutz-Jeghers polyps?

Small intestine (C) Signup and view all the answers

What is the name of the gene associated with familial Peutz-Jeghers syndrome?

STK11 (D) Signup and view all the answers

What is the characteristic of serrated adenomas?

Has malignant potential (A) Signup and view all the answers

Which type of adenoma is more likely to harbor cancer?

Villous (D) Signup and view all the answers

What is the correlation between the size of an adenoma and its malignancy?

Adenomas over 4 cm are more likely to be malignant (A) Signup and view all the answers

What is a risk factor for cancer in an individual polyp?

High-grade dysplasia (C) Signup and view all the answers

What is the primary defect in the MSI pathway?

Defect in DNA mismatch repair (B) Signup and view all the answers

What is the most common type of colonic cancer?

Adenocarcinoma (D) Signup and view all the answers

What is the characteristic of tumors in the proximal colon?

Polypoid, exophytic mass (B) Signup and view all the answers

What is the typical clinical feature of right-sided colon cancer?

Fatigue, weakness, and iron deficiency anemia (B) Signup and view all the answers

What is the characteristic of the stromal reaction in colorectal carcinoma?

Desmoplasia with firm consistency (D) Signup and view all the answers

What is the histologic feature of well-differentiated adenocarcinoma?

Elongated, hyperchromatic nuclei (D) Signup and view all the answers

What is the most important prognostic factor in adenocarcinoma of the colon?

Depth of invasion and lymph node metastasis (C) Signup and view all the answers

What is the most common type of tumor that occurs in the appendix?

Well-differentiated neuroendocrine tumor (B) Signup and view all the answers

What is the common site of distant metastasis in adenocarcinoma of the colon?

Liver and lungs (B) Signup and view all the answers

What is the characteristic feature of mucinous adenocarcinoma?

Extracellular mucin pools (B) Signup and view all the answers

According to the AJCC TNM classification, what is used for staging of colorectal carcinoma?

Depth of invasion and lymph node metastasis (A) Signup and view all the answers

What is Pseudomyxoma peritonei?

Tumor of the appendix in which Mucin with malignant cells spreading through the peritoneal cavity (B) Signup and view all the answers