COPY: Pathology of Amyloidosis and Tissue Deposits
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Questions and Answers

What is amyloidosis?

The extracellular deposition of abnormal protein

Which of the following are types of amyloid material?

  • Amyloid light (AL) (correct)
  • Amyloid associated protein (AA) (correct)
  • Fibril protein (correct)
  • P component (correct)
  • What are the two main categories of amyloidosis?

  • Primary
  • Systemic (correct)
  • Localized (correct)
  • Tertiary
  • Secondary
  • What is a common cause of secondary amyloidosis?

    <p>Chronic inflammation</p> Signup and view all the answers

    Amyloidosis is a common condition that affects most people.

    <p>False</p> Signup and view all the answers

    What are the gross characteristics of an organ affected by amyloidosis?

    <p>All of the above</p> Signup and view all the answers

    What are the two main types of microscopic stains used to identify amyloid deposits?

    <p>Haematoxylin and eosin stain and Congo red stain</p> Signup and view all the answers

    What is the primary complication of renal amyloidosis?

    <p>Kidney failure</p> Signup and view all the answers

    Which of the following conditions can be caused by amyloidosis in the heart?

    <p>All of the above</p> Signup and view all the answers

    What is the primary diagnostic tool for amyloidosis?

    <p>Biopsy</p> Signup and view all the answers

    Which of the following is a common type of connective tissue hyalinosis?

    <p>Arterial hyalinization</p> Signup and view all the answers

    What is the hallmark of cellular hyalinosis?

    <p>The presence of Mallory bodies</p> Signup and view all the answers

    Where are Russel bodies typically observed?

    <p>Inflammation rich in plasma cells</p> Signup and view all the answers

    What is the difference between mucoid and myxomatous change?

    <p>Mucoid change occurs when mucin is deposited inside cells, while myxomatous change occurs when mucin is deposited outside cells.</p> Signup and view all the answers

    Which of the following conditions is associated with melanin deficiency?

    <p>All of the above</p> Signup and view all the answers

    What is the main pigment found in hemosiderosis?

    <p>Hemosiderin</p> Signup and view all the answers

    What is the major difference between hemosiderosis and hemochromatosis?

    <p>Hemosiderosis is localized, while hemochromatosis is generalized.</p> Signup and view all the answers

    Which of the following can cause anthracosis?

    <p>All of the above</p> Signup and view all the answers

    What is the cause of gout?

    <p>Disturbance in purine metabolism leading to the deposition of sodium urate crystals in tissues.</p> Signup and view all the answers

    Where are urate crystals most commonly deposited in gout?

    <p>The joints</p> Signup and view all the answers

    Which of the following conditions is often associated with secondary gout?

    <p>Leukemia</p> Signup and view all the answers

    What is another name for metastatic calcification?

    <p>Calcinosis</p> Signup and view all the answers

    Calcification only occurs in dead tissue.

    <p>False</p> Signup and view all the answers

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