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Questions and Answers
Which type of amyloidosis is associated with monoclonal gammopathy?
What is the primary cause of AA Amyloidosis?
Which organs are commonly affected in AL Amyloidosis?
What is the characteristic feature of Localized Amyloidosis?
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What is the primary symptom of β2-Microglobulin Amyloidosis?
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Which type of amyloidosis is associated with dialysis?
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Which of the following is NOT a common symptom of AL Amyloidosis?
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Which organs are commonly affected in β2-Microglobulin Amyloidosis?
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Study Notes
Amyloidosis
Overview
- A group of diseases characterized by the accumulation of abnormal protein fibers (amyloid) in various tissues and organs
- Can affect multiple organs and systems, leading to organ dysfunction and failure
Types of Amyloidosis
AL Amyloidosis
- Primary amyloidosis or immunoglobulin light chain amyloidosis
- Associated with monoclonal gammopathy (abnormal protein production)
- Caused by the accumulation of immunoglobulin light chains in tissues and organs
- Commonly affects the:
- Heart
- Kidneys
- Liver
- Nervous system
- Gastrointestinal tract
- Symptoms: fatigue, weight loss, swelling, numbness, or tingling in hands and feet
AA Amyloidosis
- Secondary amyloidosis or reactive amyloidosis
- Associated with chronic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease)
- Caused by the accumulation of serum amyloid A protein in tissues and organs
- Commonly affects the:
- Kidneys
- Liver
- Spleen
- Symptoms: kidney damage, proteinuria, and chronic inflammation
Localized Amyloidosis
- Amyloid deposits limited to a specific tissue or organ
- Can occur in various organs, including:
- Brain (cerebral amyloid angiopathy)
- Skin (cutaneous amyloidosis)
- Lungs (pulmonary amyloidosis)
- Symptoms vary depending on the affected organ
β2-Microglobulin Amyloidosis
- Associated with dialysis-related amyloidosis
- Caused by the accumulation of β2-microglobulin in tissues and organs
- Commonly affects the:
- Joints (carpal tunnel syndrome, joint pain)
- Bones (osteonecrosis)
- Soft tissues (tendonitis, bursitis)
- Symptoms: joint pain, stiffness, and limited mobility
Amyloidosis
Overview
- Characterized by the accumulation of abnormal protein fibers (amyloid) in various tissues and organs
- Can affect multiple organs and systems, leading to organ dysfunction and failure
Types of Amyloidosis
AL Amyloidosis
- Also known as primary amyloidosis or immunoglobulin light chain amyloidosis
- Associated with monoclonal gammopathy
- Caused by the accumulation of immunoglobulin light chains in tissues and organs
- Commonly affects the heart, kidneys, liver, nervous system, and gastrointestinal tract
- Symptoms include fatigue, weight loss, swelling, numbness, or tingling in hands and feet
AA Amyloidosis
- Also known as secondary amyloidosis or reactive amyloidosis
- Associated with chronic inflammatory diseases (e.g., rheumatoid arthritis, inflammatory bowel disease)
- Caused by the accumulation of serum amyloid A protein in tissues and organs
- Commonly affects the kidneys, liver, and spleen
- Symptoms include kidney damage, proteinuria, and chronic inflammation
Localized Amyloidosis
- Amyloid deposits limited to a specific tissue or organ
- Can occur in various organs, including:
- Brain (cerebral amyloid angiopathy)
- Skin (cutaneous amyloidosis)
- Lungs (pulmonary amyloidosis)
- Symptoms vary depending on the affected organ
β2-Microglobulin Amyloidosis
- Associated with dialysis-related amyloidosis
- Caused by the accumulation of β2-microglobulin in tissues and organs
- Commonly affects the joints (carpal tunnel syndrome, joint pain), bones (osteonecrosis), and soft tissues (tendonitis, bursitis)
- Symptoms include joint pain, stiffness, and limited mobility
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Description
Learn about amyloidosis, a group of diseases characterized by the accumulation of abnormal protein fibers in various tissues and organs, and its different types.
